SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)

HUMAN STUDIES

Hematopoietic stem cell transplantation for severe and refractory lupus. Analysis after five years and fifteen patients.
Traynor AE, Barr WG, Rosa RM, Rodriguez J, Oyama Y, Baker S, Brush M, Burt RK.
Arthritis Rheum. 2002 Nov;46(11):2917-23.
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Resolution of SLE-related soft-tissue calcification following haematopoietic stem cell transplantation.
Mandelbrot DA, Santos PW, Burt RK, Oyama Y, Block GA, Ahya SN, Rosa RM, Traynor AE.
Nephrol Dial Transplant. 2008 Aug;23(8):2679-84. doi: 10.1093/ndt/gfn036. Epub 2008 Mar 7.
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Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans.
Sun L, Akiyama K, Zhang H, Yamaza T, Hou Y, Zhao S, Xu T, Le A, Shi S.
Stem Cells. 2009 Jun;27(6):1421-32. doi: 10.1002/stem.68.
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Outcome of intensive immunosuppression and autologous stem cell transplantation in patients with severe rheumatoid arthritis is associated with the composition of synovial T cell infiltration.
Verburg RJ, Flierman R, Sont JK, Ponchel F, van Dreunen L, Levarht EW, Welling MM, Toes RE, Isaacs JD, van Laar JM.
Ann Rheum Dis. 2005 Oct;64(10):1397-405. Epub 2005 Apr 13.
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Activated NF-κB in bone marrow mesenchymal stem cells from systemic lupus erythematosus patients inhibits osteogenic differentiation through downregulatingSmad signaling.
Tang Y, Xie H, Chen J, Geng L, Chen H, Li X, Hou Y, Lu L, Shi S, Zeng X, Sun L.
Stem Cells Dev. 2013 Feb 15;22(4):668-78. doi: 10.1089/scd.2012.0226. Epub 2012 Oct 10.
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Haematopoietic stem cell transplantation for active systemic lupus erythematosus.
Traynor A, Burt RK.
Rheumatology (Oxford). 1999 Aug;38(8):767-72.
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Autologous blood stem cell transplantation in refractory systemic lupus erythematosus with severe pulmonary impairment: a case report.
Brunner M, Greinix HT, Redlich K, Knöbl P, Smolen J, Leitner G, Derfler K, Graninger W, Kalhs P, Machold K.
Arthritis Rheum. 2002 Jun;46(6):1580-4.
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PRECLINICAL STUDIES

Reversal of serologic, immunologic, and histologic dysfunction in mice with systemic lupus erythematosus by long-term serial adipose tissue-derived mesenchymal stem cell transplantation.
Choi EW, Shin IS, Park SY, Park JH, Kim JS, Yoon EJ, Kang SK, Ra JC, Hong SH.
Arthritis Rheum. 2012 Jan;64(1):243-53. doi: 10.1002/art.33313.
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Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus.
Sun L, Wang D, Liang J, Zhang H, Feng X, Wang H, Hua B, Liu B, Ye S, Hu X, Xu W, Zeng X, Hou Y, Gilkeson GS, Silver RM, Lu L, Shi S.
Arthritis Rheum. 2010 Aug;62(8):2467-75. doi: 10.1002/art.27548.
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Hematopoietic stem cell transplantation for systemic lupus erythematosus.
Marmont du Haut Champ AM.
Clin Dev Immunol. 2012;2012:380391. doi: 10.1155/2012/380391. Epub 2012 Aug 30. Review.
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Interferon-γ-dependent inhibition of B cell activation by bone marrow-derived mesenchymal stem cells in a murine model of systemic lupus erythematosus.
Schena F, Gambini C, Gregorio A, Mosconi M, Reverberi D, Gattorno M, Casazza S, Uccelli A, Moretta L, Martini A, Traggiai E.
Arthritis Rheum. 2010 Sep;62(9):2776-86. doi: 10.1002/art.27560.
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REVIEW ARTICLES

Hematopoetic and mesenchymal stem cell transplantation in the treatment of refractory systemic lupus erythematosus--where are we now?
Collins E, Gilkeson G.
ClinImmunol. 2013 Sep;148(3):328-34. doi: 10.1016/j.clim.2013.01.009. Epub 2013 Jan 27. Review.
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Current state and future directions of autologous hematopoietic stem cell transplantation in systemic lupus erythematosus.
Illei GG, Cervera R, Burt RK, Doria A, Hiepe F, Jayne D, Pavletic S, Martin T, Marmont A, Saccardi R, Voskuyl AE, Farge D.
Ann Rheum Dis. 2011 Dec;70(12):2071-4. doi: 10.1136/ard.2010.148049. Epub 2011 Aug 26.
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New therapies for systemic lupus erythematosus.
Goldblatt F, Isenberg DA.
ClinExpImmunol. 2005 May;140(2):205-12. Review.
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SLE - hematopoietic stem cell transplantation for systemic lupus erythematosus.
Burt RK, Traynor AE.
Arthritis Res Ther. 2003;5(5):207-9. Epub 2003 Jun 26. Review.
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Endothelial progenitor cells: a new player in lupus?
Haque S, Alexander MY, Bruce IN.
Arthritis Res Ther. 2012 Feb 20;14(1):203. doi: 10.1186/ar3700. Review.
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Last modified: Jul 17, 2014
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