RHEUMATOID ARTHRITIS/JUVENILE IDIOPATHIC ARTHRITIS

HUMAN STUDIES

Reduction of joint damage in severe rheumatoid arthritis by high-dose chemotherapy and autologous stem cell transplantation.
Verburg RJ, Sont JK, van Laar JM.
Arthritis Rheum. 2005 Feb;52(2):421-4.
FREE ARTICLE

Allogeneic mesenchymal stem cell and mesenchymal stem cell-differentiated chondrocyte suppress the responses of type II collagen-reactive T cells in rheumatoid arthritis.
Zheng ZH, Li XY, Ding J, Jia JF, Zhu P.
Rheumatology (Oxford). 2008 Jan;47(1):22-30.
FREE ARTICLE

Long-term followup of health status in patients with severe rheumatoid arthritis after high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation.
Teng YK, Verburg RJ, Sont JK, van den Hout WB, Breedveld FC, van Laar JM.
Arthritis Rheum. 2005 Aug;52(8):2272-6.
FREE ARTICLE

Outcome of intensive immunosuppression and autologous stem cell transplantation in patients with severe rheumatoid arthritis is associated with the composition of synovial T cell infiltration.
Verburg RJ, Flierman R, Sont JK, Ponchel F, van Dreunen L, Levarht EW, Welling MM, Toes RE, Isaacs JD, van Laar JM.
Ann Rheum Dis. 2005 Oct;64(10):1397-405. Epub 2005 Apr 13.
FREE ARTICLE

High dose chemotherapy and syngeneic stem cell transplantation in a patient with refractory rheumatoid arthritis: poor response associated with persistence of host autoantibodies and synovial abnormalities.
van Oosterhout M, Verburg RJ, Levarht EW, Moolenburgh JD, Barge RM, Fibbe WE, van Laar JM.
Ann Rheum Dis. 2005 Dec;64(12):1783-5.
FREE ARTICLE

High-dose cyclophosphamide with stem cell rescue for severe rheumatoid arthritis: short-term efficacy correlates with reduction of macroscopic and histologic synovitis.
Bingham S, Veale D, Fearon U, Isaacs JD, Morgan G, Emery P, McGonagle D, Reece R, Clague R, Snowden JA.
Arthritis Rheum. 2002 Mar;46(3):837-9. No abstract available.
FREE ARTICLE

Autologous stem cell transplantation in the treatment of refractory rheumatoid arthritis.
Kim KC, Lee IH, Choi JH, Oh MR, Ahn MJ, Kim SY.
J Korean Med Sci. 2002 Feb;17(1):129-32.
FREE ARTICLE

High-dose chemotherapy and autologous hematopoietic stem cell transplantation in patients with rheumatoid arthritis: results of an open study to assess feasibility, safety, and efficacy.
Verburg RJ, Kruize AA, van den Hoogen FH, Fibbe WE, Petersen EJ, Preijers F, Sont JK, Barge RM, Bijlsma JW, van de Putte LB, Breedveld FC, van Laar JM.
Arthritis Rheum. 2001 Apr;44(4):754-60.
FREE ARTICLE

A phase I/II dose escalation study of intensified cyclophosphamide and autologous blood stem cell rescue in severe, active rheumatoid arthritis.
Snowden JA, Biggs JC, Milliken ST, Fuller A, Brooks PM.
Arthritis Rheum. 1999 Nov;42(11):2286-92.
FREE ARTICLE

Generation of disease-specific induced pluripotent stem cells from patients with rheumatoid arthritis and osteoarthritis.
Lee J, Kim Y, Yi H, Diecke S, Kim J, Jung H, Rim YA, Jung SM, Kim M, Kim YG, Park SH, Kim HY, Ju JH.
Arthritis Res Ther. 2014 Feb 4;16(1):R41. [Epub ahead of print]
FREE ARTICLE

Effect of therapeutic inhibition of TNF on circulating endothelial progenitor cells in patients with rheumatoid arthritis.
Spinelli FR, Metere A, Barbati C, Pierdominici M, Iannuccelli C, Lucchino B, Ciciarello F, Agati L, Valesini G, Di Franco M.
Mediators Inflamm. 2013;2013:537539. doi: 10.1155/2013/537539. Epub 2013 Oct 9.
FREE ARTICLE

A pilot randomized trial comparing CD34-selected versus unmanipulated hemopoietic stem cell transplantation for severe, refractory rheumatoid arthritis.
Moore J, Brooks P, Milliken S, Biggs J, Ma D, Handel M, Cannell P, Will R, Rule S, Joske D, Langlands B, Taylor K, O'Callaghan J, Szer J, Wicks I, McColl G, Passeullo F, Snowden J.
Arthritis Rheum. 2002 Sep;46(9):2301-9.
FREE ARTICLE

Autologous hematopoietic stem cell transplantation in refractory rheumatoid arthritis: sustained response in two of four patients.
Burt RK, Georganas C, Schroeder J, Traynor A, Stefka J, Schuening F, Graziano F, Mineishi S, Brush M, Fishman M, Welles C, Rosen S, Pope R.
Arthritis Rheum. 1999 Nov;42(11):2281-5.
FREE ARTICLE

Autologous stem cell transplantation: a possible treatment for refractory juvenile chronic arthritis?
Wulffraat NM, Kuis W.
Rheumatology (Oxford). 1999 Aug;38(8):764-6.
FREE ARTICLE

Intensified-dose (4 gm/m2) cyclophosphamide and granulocyte colony-stimulating factor administration for hematopoietic stem cell mobilization in refractory rheumatoid arthritis.
Breban M, Dougados M, Picard F, Zompi S, Marolleau JP, Bocaccio C, Heshmati F, Mezieres M, Dreyfus F, Bouscary D.
Arthritis Rheum. 1999 Nov;42(11):2275-80.
FREE ARTICLE

A randomised, blinded, placebo-controlled, dose escalation study of the tolerability and efficacy of filgrastim for haemopoietic stem cell mobilisation in patients with severe active rheumatoid arthritis.
Snowden JA, Biggs JC, Milliken ST, Fuller A, Staniforth D, Passuello F, Renwick J, Brooks PM.
Bone Marrow Transplant. 1998 Dec;22(11):1035-41.
FREE ARTICLE

Autologous stem cell transplantation in children with severe progressive systemic or polyarticular juvenile idiopathic arthritis: long-term follow-up of a prospective clinical trial.
Brinkman DM, de Kleer IM, ten Cate R, van Rossum MA, Bekkering WP, Fasth A, van Tol MJ, Kuis W, Wulffraat NM, Vossen JM.
Arthritis Rheum. 2007 Jul;56(7):2410-21.
FREE ARTICLE

Intense immunosuppression followed by purified blood CD34+ cell autografting in a patient with refractory juvenile rheumatoid arthritis.
Nakagawa R, Kawano Y, Yoshimura E, Suzuya H, Watanabe T, Kanamaru S, Onishi T, Nakayama H, Nakagawa R, Matsuoka S, Yamashita K, Kuroda Y.
Bone Marrow Transplant. 2001 Feb;27(3):333-6.
FREE ARTICLE

 

PRECLINICAL STUDIES

Intra-articular injection of mesenchymal stem cells leads to reduced inflammation and cartilage damage in murine antigen-induced arthritis.
Kehoe O, Cartwright A, Askari A, El Haj AJ, Middleton J.
J Transl Med. 2014 Jun 3;12(1):157. doi: 10.1186/1479-5876-12-157.
FREE ARTICLE

Preclinical Efficacy and Mechanisms of Mesenchymal Stem Cells in Animal Models of Autoimmune Diseases.
Lee HK, Lim SH, Chung IS, Park Y, Park MJ, Kim JY, Kim YG, Hong JT, Kim Y, Han SB.
Immune Netw. 2014 Apr;14(2):81-88. Epub 2014 Apr 21. Review.
FREE ARTICLE

Comparison of drug and cell-based delivery: engineered adult mesenchymal stem cells expressing soluble tumor necrosis factor receptor II prevent arthritis in mouse and rat animal models.
Liu LN, Wang G, Hendricks K, Lee K, Bohnlein E, Junker U, Mosca JD.
Stem CellsTransl Med. 2013 May;2(5):362-75. doi: 10.5966/sctm.2012-0135. Epub 2013 Apr 16.
FREE ARTICLE

Upregulation of miR-23b Enhances the Autologous Therapeutic Potential for Degenerative Arthritis by Targeting PRKACB in Synovial Fluid-Derived Mesenchymal Stem Cells from Patients.
Ham O, Lee CY, Song BW, Lee SY, Kim R, Park JH, Lee J, Seo HH, Lee CY, Chung YA, Maeng LS, Lee MY, Kim J, Hwang J, Woo DK, Chang W.
MolCells.2014 Jun 11.doi: 10.14348/molcells.2014.0023. [Epub ahead of print]
FREE ARTICLE

Adoptive transfer of human gingiva-derived mesenchymal stem cells ameliorates collagen-induced arthritis via suppression of Th1 and Th17 cells and enhancement of regulatory T cell differentiation.
Chen M, Su W, Lin X, Guo Z, Wang J, Zhang Q, Brand D, Ryffel B, Huang J, Liu Z, He X, Le AD, Zheng SG.
Arthritis Rheum. 2013 May;65(5):1181-93. doi: 10.1002/art.37894.
FREE ARTICLE

Human umbilical cord mesenchymal stem cells as treatment of adjuvant rheumatoid arthritis in a rat model.
Greish S, Abogresha N, Abdel-Hady Z, Zakaria E, Ghaly M, Hefny M.
World J Stem Cells. 2012 Oct 26;4(10):101-9. doi: 10.4252/wjsc.v4.i10.101.
FREE ARTICLE

The allogeneic umbilical cord mesenchymal stem cells regulate the function of T helper 17 cells from patients with rheumatoid arthritis in an in vitro co-culture system.
Wang Q, Li X, Luo J, Zhang L, Ma L, Lv Z, Xue L.
BMC Musculoskelet Disord. 2012 Dec 13;13:249. doi: 10.1186/1471-2474-13-249.
FREE ARTICLE

Transforming growth factor β-transduced mesenchymal stem cells ameliorate experimental autoimmune arthritis through reciprocal regulation of Treg/Th17 cells and osteoclastogenesis.
Park MJ, Park HS, Cho ML, Oh HJ, Cho YG, Min SY, Chung BH, Lee JW, Kim HY, Cho SG.
Arthritis Rheum. 2011 Jun;63(6):1668-80. doi: 10.1002/art.30326.
FREE ARTICLE

Mesenchymal stem cells overexpressing interleukin-10 attenuate collagen-induced arthritis in mice.
Choi JJ, Yoo SA, Park SJ, Kang YJ, Kim WU, Oh IH, Cho CS.
Clin Exp Immunol. 2008 Aug;153(2):269-76. doi: 10.1111/j.1365-2249.2008.03683.x.
FREE ARTICLE

Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis.
Augello A, Tasso R, Negrini SM, Cancedda R, Pennesi G.
Arthritis Rheum. 2007 Apr;56(4):1175-86.
FREE ARTICLE

REVIEW ARTICLES

Mesenchymal stem cells, autoimmunity and rheumatoid arthritis.
El-Jawhari JJ, El-Sherbiny YM, Jones EA, McGonagle D.
QJM. 2014 Mar 5. [Epub ahead of print]
FREE ARTICLE

Preclinical efficacy and mechanisms of mesenchymal stem cells in animal models of autoimmune diseases.
Lee HK, Lim SH, Chung IS, Park Y, Park MJ, Kim JY, Kim YG, Hong JT, Kim Y, Han SB.
Immune Netw. 2014 Apr;14(2):81-8. doi: 10.4110/in.2014.14.2.81. Epub 2014 Apr 21. Review.
FREE ARTICLE

Mesenchymal stem cell-based therapies in regenerative medicine: applications in rheumatology.
Maumus M, Guérit D, Toupet K, Jorgensen C, Noël D.
Stem Cell Res Ther. 2011 Mar 18;2(2):14. doi: 10.1186/scrt55. Review.
FREE ARTICLE

Endothelial progenitor cells: novel players in the pathogenesis of rheumatic diseases.
Distler JH, Beyer C, Schett G, Lüscher TF, Gay S, Distler O.
Arthritis Rheum. 2009 Nov;60(11):3168-79. doi: 10.1002/art.24921. Review. No abstract available.
FREE ARTICLE

Mesenchymal stem cells in arthritic diseases.
Chen FH, Tuan RS.
Arthritis Res Ther. 2008;10(5):223. doi: 10.1186/ar2514. Epub 2008 Oct 10. Review.
FREE ARTICLE

Stem cells for repair of cartilage and bone: the next challenge in osteoarthritis and rheumatoid arthritis.
Jorgensen C, Noel D, Apparailly F, Sany J.
Ann Rheum Dis. 2001 Apr;60(4):305-9. Review. No abstract available.
FREE ARTICLE

Last modified: Oct 14, 2014
ID=x22362