RHEUMATOID ARTHRITIS/JUVENILE IDIOPATHIC ARTHRITIS

HUMAN STUDIES

Long-term followup of health status in patients with severe rheumatoid arthritis after high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation.
Teng YK, Verburg RJ, Sont JK, van den Hout WB, Breedveld FC, van Laar JM.
Arthritis Rheum. 2005 Aug;52(8):2272-6.
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A phase I/II dose escalation study of intensified cyclophosphamide and autologous blood stem cell rescue in severe, active rheumatoid arthritis.
Snowden JA, Biggs JC, Milliken ST, Fuller A, Brooks PM.
Arthritis Rheum. 1999 Nov;42(11):2286-92.
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Generation of disease-specific induced pluripotent stem cells from patients with rheumatoid arthritis and osteoarthritis.
Lee J, Kim Y, Yi H, Diecke S, Kim J, Jung H, Rim YA, Jung SM, Kim M, Kim YG, Park SH, Kim HY, Ju JH.
Arthritis Res Ther. 2014 Feb 4;16(1):R41. [Epub ahead of print]
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Effect of therapeutic inhibition of TNF on circulating endothelial progenitor cells in patients with rheumatoid arthritis.
Spinelli FR, Metere A, Barbati C, Pierdominici M, Iannuccelli C, Lucchino B, Ciciarello F, Agati L, Valesini G, Di Franco M.
Mediators Inflamm. 2013;2013:537539. doi: 10.1155/2013/537539. Epub 2013 Oct 9.
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A pilot randomized trial comparing CD34-selected versus unmanipulated hemopoietic stem cell transplantation for severe, refractory rheumatoid arthritis.
Moore J, Brooks P, Milliken S, Biggs J, Ma D, Handel M, Cannell P, Will R, Rule S, Joske D, Langlands B, Taylor K, O'Callaghan J, Szer J, Wicks I, McColl G, Passeullo F, Snowden J.
Arthritis Rheum. 2002 Sep;46(9):2301-9.
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Autologous hematopoietic stem cell transplantation in refractory rheumatoid arthritis: sustained response in two of four patients.
Burt RK, Georganas C, Schroeder J, Traynor A, Stefka J, Schuening F, Graziano F, Mineishi S, Brush M, Fishman M, Welles C, Rosen S, Pope R.
Arthritis Rheum. 1999 Nov;42(11):2281-5.
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Autologous stem cell transplantation: a possible treatment for refractory juvenile chronic arthritis?
Wulffraat NM, Kuis W.
Rheumatology (Oxford). 1999 Aug;38(8):764-6.
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Intensified-dose (4 gm/m2) cyclophosphamide and granulocyte colony-stimulating factor administration for hematopoietic stem cell mobilization in refractory rheumatoid arthritis.
Breban M, Dougados M, Picard F, Zompi S, Marolleau JP, Bocaccio C, Heshmati F, Mezieres M, Dreyfus F, Bouscary D.
Arthritis Rheum. 1999 Nov;42(11):2275-80.
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A randomised, blinded, placebo-controlled, dose escalation study of the tolerability and efficacy of filgrastim for haemopoietic stem cell mobilisation in patients with severe active rheumatoid arthritis.
Snowden JA, Biggs JC, Milliken ST, Fuller A, Staniforth D, Passuello F, Renwick J, Brooks PM.
Bone Marrow Transplant. 1998 Dec;22(11):1035-41.
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PRECLINICAL STUDIES

Intra-articular injection of mesenchymal stem cells leads to reduced inflammation and cartilage damage in murine antigen-induced arthritis.
Kehoe O, Cartwright A, Askari A, El Haj AJ, Middleton J.
J Transl Med. 2014 Jun 3;12(1):157. doi: 10.1186/1479-5876-12-157.
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Preclinical Efficacy and Mechanisms of Mesenchymal Stem Cells in Animal Models of Autoimmune Diseases.
Lee HK, Lim SH, Chung IS, Park Y, Park MJ, Kim JY, Kim YG, Hong JT, Kim Y, Han SB.
Immune Netw. 2014 Apr;14(2):81-88. Epub 2014 Apr 21. Review.
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Comparison of drug and cell-based delivery: engineered adult mesenchymal stem cells expressing soluble tumor necrosis factor receptor II prevent arthritis in mouse and rat animal models.
Liu LN, Wang G, Hendricks K, Lee K, Bohnlein E, Junker U, Mosca JD.
Stem CellsTransl Med. 2013 May;2(5):362-75. doi: 10.5966/sctm.2012-0135. Epub 2013 Apr 16.
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Upregulation of miR-23b Enhances the Autologous Therapeutic Potential for Degenerative Arthritis by Targeting PRKACB in Synovial Fluid-Derived Mesenchymal Stem Cells from Patients.
Ham O, Lee CY, Song BW, Lee SY, Kim R, Park JH, Lee J, Seo HH, Lee CY, Chung YA, Maeng LS, Lee MY, Kim J, Hwang J, Woo DK, Chang W.
MolCells.2014 Jun 11.doi: 10.14348/molcells.2014.0023. [Epub ahead of print]
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REVIEW ARTICLES

Mesenchymal stem cells, autoimmunity and rheumatoid arthritis.
El-Jawhari JJ, El-Sherbiny YM, Jones EA, McGonagle D.
QJM. 2014 Mar 5. [Epub ahead of print]
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Last modified: Jul 17, 2014
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