OSTEOARTHRITIS

HUMAN STUDIES

Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells.
Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D.
Pain Physician. 2008 May-Jun;11(3):343-53.
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Safety reporting on implantation of autologous adipose tissue-derived stem cells with platelet-rich plasma into human articular joints.
Pak J, Chang JJ, Lee JH, Lee SH.
BMC MusculoskeletDisord. 2013 Dec 1;14:337. doi: 10.1186/1471-2474-14-337.
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Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells: a case series.
Pak J.
J Med Case Rep. 2011 Jul 7;5:296. doi: 10.1186/1752-1947-5-296.
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PRECLINICAL STUDIES

Comparison of the efficacy of bone marrow mononuclear cells and bone mesenchymal stem cells in the treatment of osteoarthritis in a sheep model.
Song F, Tang J, Geng R, Hu H, Zhu C, Cui W, Fan W.
Int J ClinExpPathol. 2014 Mar 15;7(4):1415-26. eCollection 2014.
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Cartilage regeneration by chondrogenic induced adult stem cells in osteoarthritic sheep model.
Ude CC, Sulaiman SB, Min-Hwei N, Hui-Cheng C, Ahmad J, Yahaya NM, Saim AB, Idrus RB.
PLoS One. 2014 Jun 9;9(6):e98770. doi: 10.1371/journal.pone.0098770. eCollection 2014.
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Controlled, blinded force platform analysis of the effect of intraarticular injection of autologous adipose-derived mesenchymal stem cells associated to PRGF-Endoret in osteoarthritic dogs.
Vilar JM, Morales M, Santana A, Spinella G, Rubio M, Cuervo B, Cugat R, Carrillo JM.
BMC Vet Res. 2013 Jul 2;9:131. doi: 10.1186/1746-6148-9-131.
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Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis.
Zhen G, Wen C, Jia X, Li Y, Crane JL, Mears SC, Askin FB, Frassica FJ, Chang W, Yao J, Carrino JA, Cosgarea A, Artemov D, Chen Q, Zhao Z, Zhou X, Riley L, Sponseller P, Wan M, Lu WW, Cao X.
Nat Med. 2013 Jun;19(6):704-12. doi: 10.1038/nm.3143. Epub 2013 May 19.
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A modified aggregate culture for chondrogenesis of human adipose-derived stem cells genetically modified with growth and differentiation factor 5.
Yang X, Shang H, Katz A, Li X.
Biores Open Access. 2013 Aug;2(4):258-65. doi: 10.1089/biores.2013.0014.
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Effects of Dexamethasone on Mesenchymal Stromal Cell Chondrogenesis and Aggrecanase Activity: Comparison of Agarose and Self-Assembling Peptide Scaffolds.
Florine EM, Miller RE, Porter RM, Evans CH, Kurz B, Grodzinsky AJ.
Cartilage. 2013 Jan 1;4(1):63-74.
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Small Molecule-BIO Accelerates and Enhances Marrow-Derived Mesenchymal Stem Cell in Vitro Chondrogenesis.
BaghabanEslaminejad M, Fallah N.
Iran J Med Sci. 2014 Mar;39(2):107-16.
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Bone marrow mesenchymal stem cells combined with calcium alginate gel modified by hTGF-β1 for the construction of tissue-engineered cartilage in three-dimensional conditions.
Zhu S, Zhang T, Sun C, Yu A, Qi B, Cheng H.
ExpTher Med. 2013 Jan;5(1):95-101. Epub 2012 Oct 25.
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Controlled, blinded force platform analysis of the effect of intraarticular injection of autologous adipose-derived mesenchymal stem cells associated to PRGF-Endoret in osteoarthritic dogs.
Vilar JM, Morales M, Santana A, Spinella G, Rubio M, Cuervo B, Cugat R, Carrillo JM.
BMC Vet Res. 2013 Jul 2;9:131. doi: 10.1186/1746-6148-9-131.
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Intra-articular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/MpJ superhealer mice prevents posttraumatic arthritis.
Diekman BO, Wu CL, Louer CR, Furman BD, Huebner JL, Kraus VB, Olson SA, Guilak F.
Cell Transplant. 2013;22(8):1395-408. doi: 10.3727/096368912X653264. Epub 2012 Aug 10.
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Antiinflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis.
ter Huurne M, Schelbergen R, Blattes R, Blom A, de Munter W, Grevers LC, Jeanson J, Noël D, Casteilla L, Jorgensen C, van den Berg W, van Lent PL.
Arthritis Rheum. 2012 Nov;64(11):3604-13. doi: 10.1002/art.34626.
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A stem cell-based approach to cartilage repair.
Johnson K, Zhu S, Tremblay MS, Payette JN, Wang J, Bouchez LC, Meeusen S, Althage A, Cho CY, Wu X, Schultz PG.
Science. 2012 May 11;336(6082):717-21. doi: 10.1126/science.1215157. Epub 2012 Apr 5.
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Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1.
Matsumoto T, Cooper GM, Gharaibeh B, Meszaros LB, Li G, Usas A, Fu FH, Huard J.
Arthritis Rheum. 2009 May;60(5):1390-405. doi: 10.1002/art.24443.
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The influence of sex on the chondrogenic potential of muscle-derived stem cells: implications for cartilage regeneration and repair.
Matsumoto T, Kubo S, Meszaros LB, Corsi KA, Cooper GM, Li G, Usas A, Osawa A, Fu FH, Huard J.
Arthritis Rheum. 2008 Dec;58(12):3809-19. doi: 10.1002/art.24125.
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REVIEW ARTICLES

Current perspectives in stem cell research for knee cartilage repair.
Orth P, Rey-Rico A, Venkatesan JK, Madry H, Cucchiarini M.
Stem Cells Cloning. 2014 Jan 16;7:1-17. eCollection 2014. Review.
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Stem cell-based therapies for osteoarthritis: challenges and opportunities.
Diekman BO, Guilak F.
CurrOpinRheumatol. 2013 Jan;25(1):119-26. doi: 10.1097/BOR.0b013e32835aa28d. Review.
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Stem cell therapy for human cartilage defects: a systematic review.
Pastides P, Chimutengwende-Gordon M, Maffulli N, Khan W.
Osteoarthritis Cartilage. 2013 May;21(5):646-54. doi: 10.1016/j.joca.2013.02.008. Epub 2013 Feb 26. Review.
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Mesenchymal stem cell therapy in osteoarthritis: advanced tissue repair or intervention with smouldering synovial activation?
van Lent PL, van den Berg WB.
Arthritis Res Ther. 2013 Mar 20;15(2):112. [Epub ahead of print]
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Chondrocyte and mesenchymal stem cell-based therapies for cartilage repair in osteoarthritis and related orthopaedic conditions.
Mobasheri A, Kalamegam G, Musumeci G, Batt ME.
Maturitas. 2014 May 2. pii: S0378-5122(14)00136-4. doi: 10.1016/j.maturitas.2014.04.017. [Epub ahead of print] Review.
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Stem cells in osteoarthritis.
Goldberg VM.
HSS J. 2012 Feb;8(1):59-61. doi: 10.1007/s11420-011-9262-8. Epub 2012 Jan 24. No abstract available.
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Stem cells for repair of cartilage and bone: the next challenge in osteoarthritis and rheumatoid arthritis.
Jorgensen C, Noel D, Apparailly F, Sany J.
Ann Rheum Dis. 2001 Apr;60(4):305-9. Review. No abstract available.
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Last modified: Oct 14, 2014
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