FRACTURES AND BONE DEFECTS

HUMAN STUDIES

Stem cell-based therapy for prevention of delayed fracture union: a randomized and prospective preliminary study.
Liebergall M, Schroeder J, Mosheiff R, Gazit Z, Yoram Z, Rasooly L, Daskal A, Khoury A, Weil Y, Beyth S.
Mol Ther. 2013 Aug;21(8):1631-8. doi: 10.1038/mt.2013.109. Epub 2013 Jun 4.
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Stem cell therapy for craniofacial bone regeneration: a randomized, controlled feasibility trial.
Kaigler D, Pagni G, Park CH, Braun TM, Holman LA, Yi E, Tarle SA, Bartel RL, Giannobile WV.
Cell Transplant. 2013;22(5):767-77.
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Use of autologous human mesenchymal stromal cell/fibrin clot constructs in upper limb non-unions: long-term assessment.
Giannotti S, Trombi L, Bottai V, Ghilardi M, D'Alessandro D, Danti S, Dell'Osso G, Guido G, Petrini M.
PLoS One. 2013 Aug 30;8(8):e73893. doi: 10.1371/journal.pone.0073893. eCollection 2013. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/e4403abb-b80e-43c5-be74-1bdb2c899d1c.
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PRECLINICAL STUDIES

Safety evaluation of a bioglass-polylactic acid composite scaffold seeded with progenitor cells in a rat skull critical-size bone defect.
Eldesoqi K, Henrich D, El-Kady AM, Arbid MS, Abd El-Hady BM, Marzi I, Seebach C.
PLoS One. 2014 Feb 3;9(2):e87642. doi: 10.1371/journal.pone.0087642. eCollection 2014.
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Reconstruction of beagle hemi-mandibular defects with allogenic mandibular scaffolds and autologous mesenchymal stem cells.
Liu C, Tan X, Luo J, Liu H, Hu M, Yue W.
PLoS One. 2014 Aug 25;9(8):e105733. doi: 10.1371/journal.pone.0105733. eCollection 2014.
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Bone regeneration of mouse critical-sized calvarial defects with human mesenchymal stem cells in scaffold.
Im JY, Min WK, You C, Kim HO, Jin HK, Bae JS.
Lab Anim Res. 2013 Dec;29(4):196-203. doi: 10.5625/lar.2013.29.4.196. Epub 2013 Dec 20. Erratum in: Lab Anim Res. 2014;30(1):44.
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A novel single pulsed electromagnetic field stimulates osteogenesis of bone marrow mesenchymal stem cells and bone repair.
Fu YC, Lin CC, Chang JK, Chen CH, Tai IC, Wang GJ, Ho ML.
PLoS One. 2014 Mar 14;9(3):e91581. doi: 10.1371/journal.pone.0091581. eCollection 2014.
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Enhanced Healing of Rat Calvarial Defects with MSCs Loaded on BMP-2 Releasing Chitosan/Alginate/Hydroxyapatite Scaffolds.
He X, Liu Y, Yuan X, Lu L.
PLoS One. 2014 Aug 1;9(8):e104061. doi: 10.1371/journal.pone.0104061. eCollection 2014.
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Repair of orbital bone defects in canines using grafts of enriched autologous bone marrow stromal cells.
Wang Y, Bi X, Zhou H, Deng Y, Sun J, Xiao C, Gu P, Fan X.
J Transl Med. 2014 May 11;12:123. doi: 10.1186/1479-5876-12-123.
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The effect of mesenchymal stem cell sheets on structural allograft healing of critical sized femoral defects in mice.
Long T, Zhu Z, Awad HA, Schwarz EM, Hilton MJ, Dong Y.
Biomaterials. 2014 Mar;35(9):2752-9. doi: 10.1016/j.biomaterials.2013.12.039. Epub 2014 Jan 3.
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MSC-seeded dense collagen scaffolds with a bolus dose of VEGF promote healing of large bone defects.
Gao C, Harvey EJ, Chua M, Chen BP, Jiang F, Liu Y, Li A, Wang H, Henderson JE.
EurCell Mater. 2013 Oct 13;26:195-207; discussion 207.
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Bone and cartilage repair by transplantation of induced pluripotent stem cells in murine joint defect model.
Uto S, Nishizawa S, Takasawa Y, Asawa Y, Fujihara Y, Takato T, Hoshi K.
Biomed Res. 2013;34(6):281-8.
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Association of mesenchymal stem cells with platelet rich plasma on the repair of critical calvarial defects in mice.
Monteiro BS, Del Carlo RJ, Argôlo-Neto NM, Nardi NB, Carvalho PH, Bonfá Lde P, Chagastelles PC, Moreira HN, Viloria MI, Santos BS.
Acta Cir Bras. 2012 Mar;27(3):201-9.
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Bone marrow-engrafted cells after mice umbilical cord blood transplantation differentiate into osteoblastic cells in response to fracture and placement of titanium screws.
Uchida K, Ueno M, Naruse K, Urabe K, Onuma K, Sakai R, Itoman M, Takaso M.
Exp Anim. 2012;61(4):427-33.
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Mesenchymal stem cells expressing insulin-like growth factor-I (MSCIGF) promote fracture healing and restore new bone formation in Irs1 knockout mice: analyses of MSCIGF autocrine and paracrine regenerative effects.
Granero-Moltó F, Myers TJ, Weis JA, Longobardi L, Li T, Yan Y, Case N, Rubin J, Spagnoli A.
Stem Cells. 2011 Oct;29(10):1537-48. doi: 10.1002/stem.697.
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Mesenchymal stem cells expressing osteogenic and angiogenic factors synergistically enhance bone formation in a mouse model of segmental bone defect.
Kumar S, Wan C, Ramaswamy G, Clemens TL, Ponnazhagan S.
Mol Ther. 2010 May;18(5):1026-34. doi: 10.1038/mt.2009.315. Epub 2010 Jan 12.
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REVIEW ARTICLES

Adipose mesenchymal stem cells in the field of bone tissue engineering.
Romagnoli C, Brandi ML.
World J Stem Cells. 2014 Apr 26;6(2):144-52. doi: 10.4252/wjsc.v6.i2.144. Review.
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"Ins" and "Outs" of mesenchymal stem cell osteogenesis in regenerative medicine.
Yamaguchi DT.
World J Stem Cells. 2014 Apr 26;6(2):94-110. doi: 10.4252/wjsc.v6.i2.94. Review.
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Bone morphogenetic proteins in craniofacial surgery: current techniques, clinical experiences, and the future of personalized stem cell therapy.
Chenard KE, Teven CM, He TC, Reid RR.
J Biomed Biotechnol. 2012;2012:601549. doi: 10.1155/2012/601549. Epub 2012 Nov 20. Review.
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Concise review: personalized human bone grafts for reconstructing head and face.
Bhumiratana S, Vunjak-Novakovic G.
Stem Cells Transl Med. 2012 Jan;1(1):64-9. doi: 10.5966/sctm.2011-0020. Epub 2011 Dec 7. Review.
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Bone repair cells for craniofacial regeneration.
Pagni G, Kaigler D, Rasperini G, Avila-Ortiz G, Bartel R, Giannobile WV.
Adv Drug Deliv Rev. 2012 Sep;64(12):1310-9. doi: 10.1016/j.addr.2012.03.005. Epub 2012 Mar 10. Review
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The role of stem cells in fracture healing and nonunion.
Fayaz HC, Giannoudis PV, Vrahas MS, Smith RM, Moran C, Pape HC, Krettek C, Jupiter JB.
Int Orthop. 2011 Nov;35(11):1587-97. doi: 10.1007/s00264-011-1338-z. Epub 2011 Aug 24. Review.
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Mesenchymal cells for skeletal tissue engineering.
Panetta NJ, Gupta DM, Quarto N, Longaker MT.
Panminerva Med. 2009 Mar;51(1):25-41. Review.
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Cell-based therapies for skeletal regenerative medicine.
Kwan MD, Slater BJ, Wan DC, Longaker MT.
Hum Mol Genet. 2008 Apr 15;17(R1):R93-8. doi: 10.1093/hmg/ddn071. Review.
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Stem cells in orthopedics: current concepts and possible future applications.
Bagaria V, Patil N, Sapre V, Chadda A, Singrakia M.
Indian J Med Sci. 2006 Apr;60(4):162-9. Review.
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Last modified: Oct 14, 2014
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