DISEASES OF THE SPINE

PRECLINICAL STUDIES

Differentiation of adipose-derived stem cells toward nucleus pulposus-like cells induced by hypoxia and a three-dimensional chitosan-alginate gel scaffold in vitro.
Zhang Z, Li F, Tian H, Guan K, Zhao G, Shan J, Ren D.
Chin Med J (Engl). 2014;127(2):314-21.
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Influence of hypoxia in the intervertebral disc on the biological behaviors of rat adipose- and nucleus pulposus-derived mesenchymal stem cells.
Li H, Tao Y, Liang C, Han B, Li F, Chen G, Chen Q.
Cells Tissues Organs. 2013;198(4):266-77. doi: 10.1159/000356505. Epub 2013 Dec 20.
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Effect of cryopreservation on canine and human activated nucleus pulposuscells: a feasibility study for cell therapy of the intervertebral disc.
Tanaka M, Sakai D, Hiyama A, Arai F, Nakajima D, Nukaga T, Nakai T, Mochida J.
Biores Open Access. 2013 Aug;2(4):273-82. doi: 10.1089/biores.2013.0023.
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Sox9 gene transfer enhanced regenerative effect of bone marrow mesenchymal stem cells on the degenerated intervertebral disc in a rabbit model.
Sun W, Zhang K, Liu G, Ding W, Zhao C, Xie Y, Yuan J, Sun X, Li H, Liu C, Tang T, Zhao J.
PLoS One. 2014 Apr 1;9(4):e93570. doi: 10.1371/journal.pone.0093570. eCollection 2014.
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Nonviral Gene Delivery of Growth and Differentiation Factor 5 to Human Mesenchymal Stem Cells Injected into a 3D Bovine Intervertebral Disc Organ Culture System.
Bucher C, Gazdhar A, Benneker LM, Geiser T, Gantenbein-Ritter B.
Stem Cells Int. 2013;2013:326828. doi: 10.1155/2013/326828. Epub 2013 Dec 23.
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REVIEW ARTICLES

Spinal fusion in the next generation: gene and cell therapy approaches.
Barba M, Cicione C, Bernardini C, Campana V, Pagano E, Michetti F, Logroscino G, Lattanzi W.
ScientificWorldJournal. 2014 Jan 28;2014:406159. doi: 10.1155/2014/406159. eCollection 2014.
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Biologically Based Therapy for the Intervertebral Disk: Who Is the Patient?
Erwin WM.
Global Spine J. 2013 Jun;3(3):193-200. Epub 2013 Apr 25. Review.
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Last modified: Jul 17, 2014
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