DISEASES OF THE SPINE

HUMAN STUDIES

Human umbilical cord mesenchymal stem cell transplantation for the treatment of chronic discogenic low back pain.
Pang X, Yang H, Peng B.
Pain Physician. 2014 Jul-Aug;17(4):E525-30.
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Human mesenchymal stem cells and biomaterials interaction: a promising synergy to improve spine fusion.
Barbanti Brodano G, Mazzoni E, Tognon M, Griffoni C, Manfrini M.
Eur Spine J. 2012 May;21 Suppl 1:S3-9. doi: 10.1007/s00586-012-2233-z. Epub 2012 Mar 16.
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Development of a per-operative procedure for concentrated bone marrow adjunction in postero-lateral lumbar fusion: radiological, biological and clinical assessment.
Odri GA, Hami A, Pomero V, Seite M, Heymann D, Bertrand-Vasseur A, Skalli W, Delecrin J.
Eur Spine J. 2012 Dec;21(12):2665-72. doi: 10.1007/s00586-012-2375-z. Epub 2012 May 26.
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Proliferation and osteoblastic differentiation of bone marrow stem cells: comparison of vertebral body and iliac crest.
Min WK, Bae JS, Park BC, Jeon IH, Jin HK, Son MJ, Park EK, Kim SY.
Eur Spine J. 2010 Oct;19(10):1753-60. doi: 10.1007/s00586-010-1424-8. Epub 2010 May 13.
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PRECLINICAL STUDIES

Differentiation of adipose-derived stem cells toward nucleus pulposus-like cells induced by hypoxia and a three-dimensional chitosan-alginate gel scaffold in vitro.
Zhang Z, Li F, Tian H, Guan K, Zhao G, Shan J, Ren D.
Chin Med J (Engl). 2014;127(2):314-21.
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Influence of hypoxia in the intervertebral disc on the biological behaviors of rat adipose- and nucleus pulposus-derived mesenchymal stem cells.
Li H, Tao Y, Liang C, Han B, Li F, Chen G, Chen Q.
Cells Tissues Organs. 2013;198(4):266-77. doi: 10.1159/000356505. Epub 2013 Dec 20.
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Effect of cryopreservation on canine and human activated nucleus pulposuscells: a feasibility study for cell therapy of the intervertebral disc.
Tanaka M, Sakai D, Hiyama A, Arai F, Nakajima D, Nukaga T, Nakai T, Mochida J.
Biores Open Access. 2013 Aug;2(4):273-82. doi: 10.1089/biores.2013.0023.
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Sox9 gene transfer enhanced regenerative effect of bone marrow mesenchymal stem cells on the degenerated intervertebral disc in a rabbit model.
Sun W, Zhang K, Liu G, Ding W, Zhao C, Xie Y, Yuan J, Sun X, Li H, Liu C, Tang T, Zhao J.
PLoS One. 2014 Apr 1;9(4):e93570. doi: 10.1371/journal.pone.0093570. eCollection 2014.
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Nonviral Gene Delivery of Growth and Differentiation Factor 5 to Human Mesenchymal Stem Cells Injected into a 3D Bovine Intervertebral Disc Organ Culture System.
Bucher C, Gazdhar A, Benneker LM, Geiser T, Gantenbein-Ritter B.
Stem Cells Int. 2013;2013:326828. doi: 10.1155/2013/326828. Epub 2013 Dec 23.
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Gene-modified adult stem cells regenerate vertebral bone defect in a rat model.
Sheyn D, Kallai I, Tawackoli W, Cohn Yakubovich D, Oh A, Su S, Da X, Lavi A, Kimelman-Bleich N, Zilberman Y, Li N, Bae H, Gazit Z, Pelled G, Gazit D.
Mol Pharm. 2011 Oct 3;8(5):1592-601. doi: 10.1021/mp200226c. Epub 2011 Sep 13.
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Titanium and tantalum as mesenchymal stem cell scaffolds for spinal fusion: an in vitro comparative study.
Blanco JF, Sánchez-Guijo FM, Carrancio S, Muntion S, García-Briñon J, del Cañizo MC.
Eur Spine J. 2011 Aug;20 Suppl 3:353-60. doi: 10.1007/s00586-011-1901-8. Epub 2011 Jul 16.
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Genetically modified mesenchymal stem cells induce mechanically stable posterior spine fusion.
Sheyn D, Rüthemann M, Mizrahi O, Kallai I, Zilberman Y, Tawackoli W, Kanim LE, Zhao L, Bae H, Pelled G, Snedeker JG, Gazit D.
Tissue Eng Part A. 2010 Dec;16(12):3679-86. doi: 10.1089/ten.TEA.2009.0786. Epub 2010 Sep 28.
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Effect of hyperbaric oxygen on mesenchymal stem cells for lumbar fusion in vivo.
Fu TS, Ueng SW, Tsai TT, Chen LH, Lin SS, Chen WJ.
BMC Musculoskelet Disord. 2010 Mar 19;11:52. doi: 10.1186/1471-2474-11-52.
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Mesenchymal stem cells arrest intervertebral disc degeneration through chondrocytic differentiation and stimulation of endogenous cells.
Yang F, Leung VY, Luk KD, Chan D, Cheung KM.
Mol Ther. 2009 Nov;17(11):1959-66. doi: 10.1038/mt.2009.146. Epub 2009 Jul 7.
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Evaluation of Spinal Fusion Using Bone Marrow Derived Mesenchymal Stem Cells with or without Fibroblast Growth Factor-4.
Seo HS, Jung JK, Lim MH, Hyun DK, Oh NS, Yoon SH.
J Korean Neurosurg Soc. 2009 Oct;46(4):397-402. doi: 10.3340/jkns.2009.46.4.397. Epub 2009 Oct 31.
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Acceleration of spinal fusion using syngeneic and allogeneic adult adipose derived stem cells in a rat model.
Lopez MJ, McIntosh KR, Spencer ND, Borneman JN, Horswell R, Anderson P, Yu G, Gaschen L, Gimble JM.
J Orthop Res. 2009 Mar;27(3):366-73. doi: 10.1002/jor.20735.
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Transplanted xenogenic bone marrow stem cells survive and generate new bone formation in the posterolateral lumbar spine of non-immunosuppressed rabbits.
Kim HJ, Park JB, Lee JK, Park EY, Park EA, Riew KD, Rhee SK.
Eur Spine J. 2008 Nov;17(11):1515-21. doi: 10.1007/s00586-008-0784-9. Epub 2008 Sep 25.
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Nonvirally engineered porcine adipose tissue-derived stem cells: use in posterior spinal fusion.
Sheyn D, Pelled G, Zilberman Y, Talasazan F, Frank JM, Gazit D, Gazit Z.
Stem Cells. 2008 Apr;26(4):1056-64. doi: 10.1634/stemcells.2007-0858. Epub 2008 Jan 24.
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Experimental posterolateral spinal fusion with porous ceramics and mesenchymal stem cells.
Cinotti G, Patti AM, Vulcano A, Della Rocca C, Polveroni G, Giannicola G, Postacchini F.
J Bone Joint Surg Br. 2004 Jan;86(1):135-42. Erratum in: J Bone Joint Surg Br. 2004 May;86(4):622.
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REVIEW ARTICLES

Spinal fusion in the next generation: gene and cell therapy approaches.
Barba M, Cicione C, Bernardini C, Campana V, Pagano E, Michetti F, Logroscino G, Lattanzi W.
ScientificWorldJournal. 2014 Jan 28;2014:406159. doi: 10.1155/2014/406159. eCollection 2014.
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Biologically Based Therapy for the Intervertebral Disk: Who Is the Patient?
Erwin WM.
Global Spine J. 2013 Jun;3(3):193-200. Epub 2013 Apr 25. Review.
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Future perspectives of cell-based therapy for intervertebral disc disease.
Sakai D.
Eur Spine J. 2008 Dec;17 Suppl 4:452-8. doi: 10.1007/s00586-008-0743-5. Epub 2008 Nov 13. Review.
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Stem cells in orthopedics: current concepts and possible future applications.
Bagaria V, Patil N, Sapre V, Chadda A, Singrakia M.
Indian J Med Sci. 2006 Apr;60(4):162-9. Review.
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Last modified: Oct 14, 2014
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