Chronic Ischemic Cardiomyopathy and Heart Failure

Heart failure due to previous heart attacks (Ischemic Cardiomyopathy):

 

HUMAN STUDIES

Effect of transendocardial delivery of autologous bone marrow mononuclear cells on functional capacity, left ventricular function, and perfusion in chronic heart failure: the FOCUS-CCTRN trial.
Perin EC, Willerson JT, Pepine CJ, Henry TD, Ellis SG, Zhao DX, Silva GV, Lai D, Thomas JD, Kronenberg MW, Martin AD, Anderson RD, Traverse JH, Penn MS, Anwaruddin S, Hatzopoulos AK, Gee AP, Taylor DA, Cogle CR, Smith D, Westbrook L, Chen J, Handberg E, Olson RE, Geither C, Bowman S, Francescon J, Baraniuk S, Piller LB, Simpson LM, Loghin C, Aguilar D, Richman S, Zierold C, Bettencourt J, Sayre SL, Vojvodic RW, Skarlatos SI, Gordon DJ, Ebert RF, Kwak M, Moyé LA, Simari RD; Cardiovascular Cell Therapy Research Network (CCTRN).
JAMA. 2012 Apr 25;307(16):1717-26. doi: 10.1001/jama.2012.418. Epub 2012 Mar 24.
FREE ARTICLE

Transcoronary transplantation of functionally competent BMCs is associated with a decrease in natriuretic peptide serum levels and improved survival of patients with chronic postinfarction heart failure: results of the TOPCARE-CHD Registry.
Assmus B, Fischer-Rasokat U, Honold J, Seeger FH, Fichtlscherer S, Tonn T, Seifried E, Schächinger V, Dimmeler S, Zeiher AM; TOPCARE-CHD Registry.
Circ Res. 2007 Apr 27;100(8):1234-41. Epub 2007 Mar 22.
FREE ARTICLE

Administration of cardiac stem cells in patients with ischemic cardiomyopathy: the SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonance.
Chugh AR, Beache GM, Loughran JH, Mewton N, Elmore JB, Kajstura J, Pappas P, Tatooles A, Stoddard MF, Lima JA, Slaughter MS, Anversa P, Bolli R.
Circulation. 2012 Sep 11;126(11 Suppl 1):S54-64.
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Procedural safety and predictors of acute outcome of intracoronary administration of progenitor cells in 775 consecutive procedures performed for acute myocardial infarction or chronic heart failure.
De Rosa S, Seeger FH, Honold J, Fischer-Rasokat U, Lehmann R, Fichtlscherer S, Schächinger V, Dimmeler S, Zeiher AM, Assmus B.
Circ Cardiovasc Interv. 2013 Feb;6(1):44-51. doi: 10.1161/CIRCINTERVENTIONS.112.971705. Epub 2013 Jan 29.
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Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial.
Bolli R, Chugh AR, D'Amario D, Loughran JH, Stoddard MF, Ikram S, Beache GM, Wagner SG, Leri A, Hosoda T, Sanada F, Elmore JB, Goichberg P, Cappetta D, Solankhi NK, Fahsah I, Rokosh DG, Slaughter MS, Kajstura J, Anversa P.
Lancet. 2011 Nov 26;378(9806):1847-57. doi: 10.1016/S0140-6736(11)61590-0. Epub 2011 Nov 14.
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Intramyocardial, autologous CD34+ cell therapy for refractory angina.
Losordo DW, Henry TD, Davidson C, Sup Lee J, Costa MA, Bass T, Mendelsohn F, Fortuin FD, Pepine CJ, Traverse JH, Amrani D, Ewenstein BM, Riedel N, Story K, Barker K, Povsic TJ, Harrington RA, Schatz RA; ACT34-CMI Investigators.
Circ Res. 2011 Aug 5;109(4):428-36. doi: 10.1161/CIRCRESAHA.111.245993. Epub 2011 Jul 7.
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Improved functional activity of bone marrow derived circulating progenitor cells after intra coronary freshly isolated bone marrow cells transplantation in patients with ischemic heart disease.
Turan RG, Bozdag-T I, Ortak J, Kische S, Akin I, Schneider H, Turan CH, Rehders TC, Rauchhaus M, Kleinfeldt T, Belu C, Brehm M, Yokus S, Steiner S, Sahin K, Nienaber CA, Ince H.
Stem Cell Rev. 2011 Sep;7(3):646-56. doi: 10.1007/s12015-010-9220-8.
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Repeated intracoronary infusion of peripheral blood stem cells with G-CSF in patients with refractory ischemic heart failure--a pilot study.
Gu X, Xie Y, Gu J, Sun L, He S, Xu R, Duan J, Zhao J, Hang F, Xu H, Li M, Cao K, Geng Y.
Circ J. 2011;75(4):955-63. Epub 2011 Feb 11.
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Functional recovery following intracoronary infusion of autologous mononuclear bone marrow cells in patients with chronic anterior myocardial infarction and severely depressed ventricular function.
Suárez de Lezo J, Herrera C, Romero MA, Pan M, Jiménez R, Carmona D, Segura JM, Nogueras S, Mesa D, Suárez de Lezo J, Pavlovic D, Ojeda S, Torres A.
Rev Esp Cardiol. 2010 Oct;63(10):1127-35. English, Spanish.
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Efficiency of intramyocardial injections of autologous bone marrow mononuclear cells in patients with ischemic heart failure: a randomized study.
Pokushalov E, Romanov A, Chernyavsky A, Larionov P, Terekhov I, Artyomenko S, Poveshenko O, Kliver E, Shirokova N, Karaskov A, Dib N.
J Cardiovasc Transl Res. 2010 Apr;3(2):160-8. doi: 10.1007/s12265-009-9123-8. Epub 2009 Sep 24.
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Bypass grafts and cell transplant in heart failure with low ejection fraction.
Rivas-Plata A, Castillo J, Pariona M, Chunga A.
Asian Cardiovasc Thorac Ann. 2010 Oct;18(5):425-9. doi: 10.1177/0218492310379939.
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Outcome of allogeneic hematopoietic stem cell transplantation in patients with low left ventricular ejection fraction.
Qazilbash MH, Amjad AI, Qureshi S, Qureshi SR, Saliba RM, Khan ZU, Hosing C, Giralt SA, De Lima MJ, Popat UR, Yusuf SW, Champlin RE.
Biol Blood Marrow Transplant. 2009 Oct;15(10):1265-70. doi: 10.1016/j.bbmt.2009.06.001. Epub 2009 Aug 3.
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One-year follow-up of feasibility and safety of the first U.S., randomized, controlled study using 3-dimensional guided catheter-based delivery of autologous skeletal myoblasts for ischemic cardiomyopathy (CAuSMIC study).
Dib N, Dinsmore J, Lababidi Z, White B, Moravec S, Campbell A, Rosenbaum A, Seyedmadani K, Jaber WA, Rizenhour CS, Diethrich E.
JACC Cardiovasc Interv. 2009 Jan;2(1):9-16. doi: 10.1016/j.jcin.2008.11.003.
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Five-year follow-up after transepicardial implantation of autologous bone marrow mononuclear cells to ungraftable coronary territories for patients with ischaemic cardiomyopathy.
Akar AR, Durdu S, Arat M, Kilickap M, Kucuk NO, Arslan O, Kuzu I, Ozyurda U.
Eur J Cardiothorac Surg. 2009 Oct;36(4):633-43. doi: 10.1016/j.ejcts.2009.04.045. Epub 2009 Jun 12.
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Randomized, controlled trial of intramuscular or intracoronary injection of autologous bone marrow cells into scarred myocardium during CABG versus CABG alone.
Ang KL, Chin D, Leyva F, Foley P, Kubal C, Chalil S, Srinivasan L, Bernhardt L, Stevens S, Shenje LT, Galiñanes M.
Nat Clin Pract Cardiovasc Med. 2008 Oct;5(10):663-70. doi: 10.1038/ncpcardio1321. Epub 2008 Aug 19.
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Randomized study of mononuclear bone marrow cell transplantation in patients with coronary surgery.
Zhao Q, Sun Y, Xia L, Chen A, Wang Z.
Ann Thorac Surg. 2008 Dec;86(6):1833-40. doi: 10.1016/j.athoracsur.2008.08.068.
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Effect of progenitor cells on myocardial perfusion and metabolism in patients after recanalization of a chronically occluded coronary artery.
Kendziorra K, Barthel H, Erbs S, Emmrich F, Hambrecht R, Schuler G, Sabri O, Kluge R.
J Nucl Med. 2008 Apr;49(4):557-63. doi: 10.2967/jnumed.107.046706. Epub 2008 Mar 14.
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Administration of intracoronary bone marrow mononuclear cells on chronic myocardial infarction improves diastolic function.
Yao K, Huang R, Qian J, Cui J, Ge L, Li Y, Zhang F, Shi H, Huang D, Zhang S, Sun A, Zou Y, Ge J.
Heart. 2008 Sep;94(9):1147-53. doi: 10.1136/hrt.2007.137919. Epub 2008 Apr 1.
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The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation.
Menasché P, Alfieri O, Janssens S, McKenna W, Reichenspurner H, Trinquart L, Vilquin JT, Marolleau JP, Seymour B, Larghero J, Lake S, Chatellier G, Solomon S, Desnos M, Hagège AA.
Circulation. 2008 Mar 4;117(9):1189-200. doi: 10.1161/CIRCULATIONAHA.107.734103. Epub 2008 Feb 19.
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Autologous in vitro expanded mesenchymal stem cell therapy for human old myocardial infarction.
Mohyeddin-Bonab M, Mohamad-Hassani MR, Alimoghaddam K, Sanatkar M, Gasemi M, Mirkhani H, Radmehr H, Salehi M, Eslami M, Farhig-Parsa A, Emami-Razavi H, Alemohammad MG, Solimani AA, Ghavamzadeh A, Nikbin B.
Arch Iran Med. 2007 Oct;10(4):467-73. Erratum in: Arch Iran Med. 2008 Mar;11(2):241. al-Mohamad, Mahmood Ghasemi [corrected to Alemohammad, Mahmood Gholan].
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Intramyocardial transplantation of autologous CD34+ stem cells for intractable angina: a phase I/IIa double-blind, randomized controlled trial.
Losordo DW, Schatz RA, White CJ, Udelson JE, Veereshwarayya V, Durgin M, Poh KK, Weinstein R, Kearney M, Chaudhry M, Burg A, Eaton L, Heyd L, Thorne T, Shturman L, Hoffmeister P, Story K, Zak V, Dowling D, Traverse JH, Olson RE, Flanagan J, Sodano D, Murayama T, Kawamoto A, Kusano KF, Wollins J, Welt F, Shah P, Soukas P, Asahara T, Henry TD.
Circulation. 2007 Jun 26;115(25):3165-72. Epub 2007 Jun 11.
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Prospective randomized trial of direct endomyocardial implantation of bone marrow cells for treatment of severe coronary artery diseases (PROTECT-CAD trial).
Tse HF, Thambar S, Kwong YL, Rowlings P, Bellamy G, McCrohon J, Thomas P, Bastian B, Chan JK, Lo G, Ho CL, Chan WS, Kwong RY, Parker A, Hauser TH, Chan J, Fong DY, Lau CP.
Eur Heart J. 2007 Dec;28(24):2998-3005. Epub 2007 Nov 5.
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Intramyocardial delivery of CD133+ bone marrow cells and coronary artery bypass grafting for chronic ischemic heart disease: safety and efficacy studies.
Stamm C, Kleine HD, Choi YH, Dunkelmann S, Lauffs JA, Lorenzen B, David A, Liebold A, Nienaber C, Zurakowski D, Freund M, Steinhoff G.
J Thorac Cardiovasc Surg. 2007 Mar;133(3):717-25. Epub 2007 Feb 1.
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Autologous bone marrow mononuclear cell transplantation in patients undergoing coronary artery bypass grafting.
Mocini D, Staibano M, Mele L, Giannantoni P, Menichella G, Colivicchi F, Sordini P, Salera P, Tubaro M, Santini M.
Am Heart J. 2006 Jan;151(1):192-7.
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Recovery of regional but not global contractile function by the direct intramyocardial autologous bone marrow transplantation: results from a randomized controlled clinical trial.
Hendrikx M, Hensen K, Clijsters C, Jongen H, Koninckx R, Bijnens E, Ingels M, Jacobs A, Geukens R, Dendale P, Vijgen J, Dilling D, Steels P, Mees U, Rummens JL.
Circulation. 2006 Jul 4;114(1 Suppl):I101-7.
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Skeletal myoblast transplantation in ischemic heart failure: long-term follow-up of the first phase I cohort of patients.
Hagège AA, Marolleau JP, Vilquin JT, Alhéritière A, Peyrard S, Duboc D, Abergel E, Messas E, Mousseaux E, Schwartz K, Desnos M, Menasché P.
Circulation. 2006 Jul 4;114(1 Suppl):I108-13.
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Surgical treatment for congestive heart failure with autologous adult stem cell transplantation: a prospective randomized study.
Patel AN, Geffner L, Vina RF, Saslavsky J, Urschel HC Jr, Kormos R, Benetti F.
J Thorac Cardiovasc Surg. 2005 Dec;130(6):1631-8. Epub 2005 Oct 26.
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Regeneration of human infarcted heart muscle by intracoronary autologous bone marrow cell transplantation in chronic coronary artery disease: the IACT Study.
Strauer BE, Brehm M, Zeus T, Bartsch T, Schannwell C, Antke C, Sorg RV, Kögler G, Wernet P, Müller HW, Köstering M.
J Am Coll Cardiol. 2005 Nov 1;46(9):1651-8.
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Scintigraphic assessment of the effects of bone marrow-derived mononuclear cell transplantation combined with off-pump coronary artery bypass surgery in patients with ischemic heart disease.
Yaoita H, Takase S, Maruyama Y, Sato Y, Satokawa H, Hoshi N, Ono N, Igari T, Ohto H, Yokoyama H.
J Nucl Med. 2005 Oct;46(10):1610-7.
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Transplantation of blood-derived progenitor cells after recanalization of chronic coronary artery occlusion: first randomized and placebo-controlled study.
Erbs S, Linke A, Adams V, Lenk K, Thiele H, Diederich KW, Emmrich F, Kluge R, Kendziorra K, Sabri O, Schuler G, Hambrecht R.
Circ Res. 2005 Oct 14;97(8):756-62. Epub 2005 Sep 8.
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Improved exercise capacity and ischemia 6 and 12 months after transendocardial injection of autologous bone marrow mononuclear cells for ischemic cardiomyopathy.
Perin EC, Dohmann HF, Borojevic R, Silva SA, Sousa AL, Silva GV, Mesquita CT, Belém L, Vaughn WK, Rangel FO, Assad JA, Carvalho AC, Branco RV, Rossi MI, Dohmann HJ, Willerson JT.
Circulation. 2004 Sep 14;110(11 Suppl 1):II213-8.
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Transendocardial autologous bone marrow mononuclear cell injection in ischemic heart failure: postmortem anatomicopathologic and immunohistochemical findings.
Dohmann HF, Perin EC, Takiya CM, Silva GV, Silva SA, Sousa AL, Mesquita CT, Rossi MI, Pascarelli BM, Assis IM, Dutra HS, Assad JA, Castello-Branco RV, Drummond C, Dohmann HJ, Willerson JT, Borojevic R.
Circulation. 2005 Jul 26;112(4):521-6. Epub 2005 Jul 18.
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Autologous intramyocardial injection of cultured skeletal muscle-derived stem cells in patients with non-acute myocardial infarction.
Herreros J, Prósper F, Perez A, Gavira JJ, Garcia-Velloso MJ, Barba J, Sánchez PL, Cañizo C, Rábago G, Martí-Climent JM, Hernández M, López-Holgado N, González-Santos JM, Martín-Luengo C, Alegria E.
Eur Heart J. 2003 Nov;24(22):2012-20.
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Pilot study to evaluate the safety and feasibility of intracoronary CD133(+) and CD133(-) CD34(+) cell therapy in patients with nonviable anterior myocardial infarction.
Manginas A, Goussetis E, Koutelou M, Karatasakis G, Peristeri I, Theodorakos A, Leontiadis E, Plessas N, Theodosaki M, Graphakos S, Cokkinos DV.
Catheter Cardiovasc Interv. 2007 May 1;69(6):773-81.
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Randomized, double-blind pilot study of transendocardial injection of autologous aldehyde dehydrogenase-bright stem cells in patients with ischemic heart failure.
Perin EC, Silva GV, Zheng Y, Gahremanpour A, Canales J, Patel D, Fernandes MR, Keller LH, Quan X, Coulter SA, Moore WH, Herlihy JP, Willerson JT.
Am Heart J. 2012 Mar;163(3):415-21, 421.e1. doi: 10.1016/j.ahj.2011.11.020. Epub 2012 Feb 10.

Preoperative mobilization of bone marrow-derived cells followed by revascularization surgery: early and long-term outcome.
Dato GM, Sansone F, Omedé P, Zingarelli E, Flocco R, Punta G, Parisi F, Forsennati PG, Bardi GL, Del Ponte S, Casabona R, Tarella C.
Int J Artif Organs. 2012 Jan;35(1):67-76. doi: 10.5301/ijao.5000021.

A randomized study of transendocardial injection of autologous bone marrow mononuclear cells and cell function analysis in ischemic heart failure (FOCUS-HF).
Perin EC, Silva GV, Henry TD, Cabreira-Hansen MG, Moore WH, Coulter SA, Herlihy JP, Fernandes MR, Cheong BY, Flamm SD, Traverse JH, Zheng Y, Smith D, Shaw S, Westbrook L, Olson R, Patel D, Gahremanpour A, Canales J, Vaughn WK, Willerson JT.
Am Heart J. 2011 Jun;161(6):1078-87.e3. doi: 10.1016/j.ahj.2011.01.028. Epub 2011 May 10.

Myocardial homing and coronary endothelial function after autologous blood CD34+ progenitor cells intracoronary injection in the chronic phase of myocardial infarction.
Dedobbeleer C, Blocklet D, Toungouz M, Lambermont M, Unger P, Degaute JP, Goldman S, Berkenboom G.
J Cardiovasc Pharmacol. 2009 Jun;53(6):480-5. doi: 10.1097/FJC.0b013e3181a7b572

Autologous bone marrow-derived stem cells for ischemic heart failure: REGENERATE-IHD trial.
Yeo C, Mathur A.
Regen Med. 2009 Jan;4(1):119-27. doi: 10.2217/17460751.4.1.119.

Safety and efficacy of consecutive cycles of granulocyte-colony stimulating factor, and an intracoronary CD133+ cell infusion in patients with chronic refractory ischemic heart disease: the G-CSF in angina patients with IHD to stimulate neovascularization (GAIN I) trial.
Kovacic JC, Macdonald P, Feneley MP, Muller DW, Freund J, Dodds A, Milliken S, Tao H, Itescu S, Moore J, Ma D, Graham RM.
Am Heart J. 2008 Nov;156(5):954-63. doi: 10.1016/j.ahj.2008.04.034.

Bone marrow stem cell transplantation and coronary artery bypass grafting surgery for chronic ischemic myocardiopathy.
da Rocha Loures DR, de Souza JM, Sermann OA, Farah N, Rodriguez MF, Malvezzi M, Borgonovo T, Westphal RJ, Ervilha L, da Cunha CP.
Heart Surg Forum. 2010 Jun;13(3):E161-4. doi: 10.1532/HSF98.20091143

A double-blind, randomized, controlled, multicenter study to assess the safety and cardiovascular effects of skeletal myoblast implantation by catheter delivery in patients with chronic heart failure after myocardial infarction.
Povsic TJ, O'Connor CM, Henry T, Taussig A, Kereiakes DJ, Fortuin FD, Niederman A, Schatz R, Spencer R 4th, Owens D, Banks M, Joseph D, Roberts R, Alexander JH, Sherman W.
Am Heart J. 2011 Oct;162(4):654-662.e1. doi: 10.1016/j.ahj.2011.07.020. Epub 2011 Sep 9.

Intracoronary infusion of CD133+ endothelial progenitor cells improves heart function and quality of life in patients with chronic post-infarct heart insufficiency.
Flores-Ramírez R, Uribe-Longoria A, Rangel-Fuentes MM, Gutiérrez-Fajardo P, Salazar-Riojas R, Cervantes-García D, Treviño-Ortiz JH, Benavides-Chereti GJ, Espinosa-Oliveros LP, Limón-Rodríguez RH, Monreal-Puente R, González-Treviño JL, Rojas-Martínez A.
Cardiovasc Revasc Med. 2010 Apr-Jun;11(2):72-8. doi: 10.1016/j.carrev.2009.04.001.

Early increase in myocardial perfusion after stem cell therapy in patients undergoing incomplete coronary artery bypass surgery.
Gowdak LH, Schettert IT, Rochitte CE, Lisboa LA, Dallan LA, César LA, de Oliveira SA, Krieger JE.
J Cardiovasc Transl Res. 2011 Feb;4(1):106-13. doi: 10.1007/s12265-010-9234-2.

Does transendocardial injection of mesenchymal stem cells improve myocardial function locally or globally?: An analysis from the Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis (POSEIDON) randomized trial.
Suncion VY, Ghersin E, Fishman JE, Zambrano JP, Karantalis V, Mandel N, Nelson KH, Gerstenblith G, DiFede Velazquez DL, Breton E, Sitammagari K, Schulman IH, Taldone SN, Williams AR, Sanina C, Johnston PV, Brinker J, Altman P, Mushtaq M, Trachtenberg B, Mendizabal AM, Tracy M, Da Silva J, McNiece IK, Lardo AC, George RT, Hare JM, Heldman AW.
Circ Res. 2014 Apr 11;114(8):1292-301. doi: 10.1161/CIRCRESAHA.114.302854. Epub 2014 Jan 21.

The effects of age, disease state, and granulocyte colony-stimulating factor on progenitor cell count and function in patients undergoing cell therapy for cardiac disease.
Mozid AM, Jones D, Arnous S, Saunders N, Wragg A, Martin J, Agrawal S, Mathur A.
Stem Cells Dev. 2013 Jan 15;22(2):216-23. doi: 10.1089/scd.2012.0139. Epub 2012 Sep 7.

Transendocardial mesenchymal stem cells and mononuclear bone marrow cells for ischemic cardiomyopathy: the TAC-HFT randomized trial.
Heldman AW, DiFede DL, Fishman JE, Zambrano JP, Trachtenberg BH, Karantalis V, Mushtaq M, Williams AR, Suncion VY, McNiece IK, Ghersin E, Soto V, Lopera G, Miki R, Willens H, Hendel R, Mitrani R, Pattany P, Feigenbaum G, Oskouei B, Byrnes J, Lowery MH, Sierra J, Pujol MV, Delgado C, Gonzalez PJ, Rodriguez JE, Bagno LL, Rouy D, Altman P, Foo CW, da Silva J, Anderson E, Schwarz R, Mendizabal A, Hare JM.
JAMA. 2014 Jan 1;311(1):62-73. doi: 10.1001/jama.2013.282909.

Cardiopoieticstem cell therapy in heart failure: the C-CURE (Cardiopoieticstem Cell therapy in heartfailURE) multicenter randomized trial with lineage-specified biologics.
Bartunek J, Behfar A, Dolatabadi D, Vanderheyden M, Ostojic M, Dens J, El Nakadi B, Banovic M, Beleslin B, Vrolix M, Legrand V, Vrints C, Vanoverschelde JL, Crespo-Diaz R, Homsy C, Tendera M, Waldman S, Wijns W, Terzic A.
J Am CollCardiol. 2013 Jun 11;61(23):2329-38. doi: 10.1016/j.jacc.2013.02.071. Epub 2013 Apr 10. Erratum in: J Am CollCardiol. 2013 Dec 24;62(25):2457-8.

Percutaneous, transendocardial injection of bone marrow-derived mononuclear cells in heart failure patients following acute ST-elevation myocardial infarction: ALSTER-Stem Cell trial.
Heeger CH, Jaquet K, Thiele H, Zulkarnaen Y, Cuneo A, Haller D, Kivelitz D, Schmidt T, Krause K, Metzner A, Schneider C, Kuck KH, Bergmann MW.
EuroIntervention. 2012 Oct;8(6):732-42. doi: 10.4244/EIJV8I6A113.

Rationale and design of the first randomized, double-blind, placebo-controlled trial of intramyocardial injection of autologous bone-marrow derived Mesenchymal Stromal Cells in chronic ischemic Heart Failure (MSC-HF Trial).
Mathiasen AB, Jørgensen E, Qayyum AA, Haack-Sørensen M, Ekblond A, Kastrup J.
Am Heart J. 2012 Sep;164(3):285-91. doi: 10.1016/j.ahj.2012.05.026.


 

PRECLINICAL STUDIES

Effect of cardiac stem cells on left-ventricular remodeling in a canine model of chronic myocardial infarction.
Welt FG, Gallegos R, Connell J, Kajstura J, D'Amario D, Kwong RY, Coelho-Filho O, Shah R, Mitchell R, Leri A, Foley L, Anversa P, Pfeffer MA.
Circ Heart Fail. 2013 Jan;6(1):99-106. doi: 10.1161/CIRCHEARTFAILURE.112.972273. Epub 2012 Dec 4.
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Functionally competent cardiac stem cells can be isolated from endomyocardial biopsies of patients with advanced cardiomyopathies.
D'Amario D, Fiorini C, Campbell PM, Goichberg P, Sanada F, Zheng H, Hosoda T, Rota M, Connell JM, Gallegos RP, Welt FG, Givertz MM, Mitchell RN, Leri A, Kajstura J, Pfeffer MA, Anversa P.
Circ Res. 2011 Apr 1;108(7):857-61. doi: 10.1161/CIRCRESAHA.111.241380. Epub 2011 Feb 17.
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Noncanonical Wnt11 signaling is sufficient to induce cardiomyogenic differentiation in unfractionated bone marrow mononuclear cells.
Flaherty MP, Abdel-Latif A, Li Q, Hunt G, Ranjan S, Ou Q, Tang XL, Johnson RK, Bolli R, Dawn B.
Circulation. 2008 Apr 29;117(17):2241-52. doi: 10.1161/CIRCULATIONAHA.107.741066. Epub 2008 Apr 21.
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Local activation or implantation of cardiac progenitor cells rescues scarred infarcted myocardium improving cardiac function.
Rota M, Padin-Iruegas ME, Misao Y, De Angelis A, Maestroni S, Ferreira-Martins J, Fiumana E, Rastaldo R, Arcarese ML, Mitchell TS, Boni A, Bolli R, Urbanek K, Hosoda T, Anversa P, Leri A, Kajstura J.
Circ Res. 2008 Jul 3;103(1):107-16. doi: 10.1161/CIRCRESAHA.108.178525. Epub 2008 Jun 12.
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Bcl-2 engineered MSCs inhibited apoptosis and improved heart function.
Li W, Ma N, Ong LL, Nesselmann C, Klopsch C, Ladilov Y, Furlani D, Piechaczek C, Moebius JM, Lützow K, Lendlein A, Stamm C, Li RK, Steinhoff G.
Stem Cells. 2007 Aug;25(8):2118-27. Epub 2007 May 3.
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Human cardiac stem cells.
Bearzi C, Rota M, Hosoda T, Tillmanns J, Nascimbene A, De Angelis A, Yasuzawa-Amano S, Trofimova I, Siggins RW, Lecapitaine N, Cascapera S, Beltrami AP, D'Alessandro DA, Zias E, Quaini F, Urbanek K, Michler RE, Bolli R, Kajstura J, Leri A, Anversa P.
Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14068-73. Epub 2007 Aug 20.
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Sca-1 expression is associated with decreased cardiomyogenic differentiation potential of skeletal muscle-derived adult primitive cells.
Zuba-Surma EK, Abdel-Latif A, Case J, Tiwari S, Hunt G, Kucia M, Vincent RJ, Ranjan S, Ratajczak MZ, Srour EF, Bolli R, Dawn B.
J MolCellCardiol. 2006 Oct;41(4):650-60. Epub 2006 Aug 30.
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Bone marrow stromal cells improve cardiac performance in healed infarcted rat hearts.
Olivares EL, Ribeiro VP, Werneck de Castro JP, Ribeiro KC, Mattos EC, Goldenberg RC, Mill JG, Dohmann HF, dos Santos RR, de Carvalho AC, Masuda MO.
Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H464-70. Epub 2004 Mar 25.
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Reversal of ischemic cardiomyopathy with sca-1+ stem cells modified with multiple growth factors.
Li N, Pasha Z, Ashraf M.
PLoS One. 2014 Apr 4;9(4):e93645. doi: 10.1371/journal.pone.0093645. eCollection 2014.
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Insulin-like growth factor-1 receptor identifies a pool of human cardiac stem cells with superior therapeutic potential for myocardial regeneration.
D'Amario D, Cabral-Da-Silva MC, Zheng H, Fiorini C, Goichberg P, Steadman E, Ferreira-Martins J, Sanada F, Piccoli M, Cappetta D, D'Alessandro DA, Michler RE, Hosoda T, Anastasia L, Rota M, Leri A, Anversa P, Kajstura J.
Circ Res. 2011 Jun 10;108(12):1467-81. doi: 10.1161/CIRCRESAHA.111.240648. Epub 2011 May 5.
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Formation of large coronary arteries by cardiac progenitor cells.
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