Acute Myocardial Infarction

Numerous studies have been conducted in animal models to examine whether adult stem cells are able to induce heart repair. Several articles based on the specific disease process are listed below:

Acute Myocardial Infarction (Heart Attack):

 

HUMAN STUDIES

Autologous transplantation of bone marrow cells improves damaged heart function.
Tomita S, Li RK, Weisel RD, Mickle DA, Kim EJ, Sakai T, Jia ZQ.
Circulation. 1999 Nov 9;100(19 Suppl):II247-56.
Free Article

Adult bone marrow-derived cells do not acquire functional attributes of cardiomyocytes when transplanted into peri-infarct myocardium.
Scherschel JA, Soonpaa MH, Srour EF, Field LJ, Rubart M.
Mol Ther. 2008 Jun;16(6):1129-37. doi: 10.1038/mt.2008.64. Epub 2008 Apr 22.
Free Article

Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing Akt on cardiac metabolism after myocardial infarction.
Gnecchi M, He H, Melo LG, Noiseaux N, Morello F, de Boer RA, Zhang L, Pratt RE, Dzau VJ, Ingwall JS.
Stem Cells. 2009 Apr;27(4):971-9. doi: 10.1002/stem.12. 
Free Article

Intramyocardial injection of autologous bone marrow-derived ex vivo expanded mesenchymal stem cells in acute myocardial infarction patients is feasible and safe up to 5 years of follow-up.
Rodrigo SF, van Ramshorst J, Hoogslag GE, Boden H, Velders MA, Cannegieter SC, Roelofs H, Al Younis I, Dibbets-Schneider P, Fibbe WE, Zwaginga JJ, Bax JJ, Schalij MJ, Beeres SL, Atsma DE.
J Cardiovasc Transl Res. 2013 Oct;6(5):816-25. doi: 10.1007/s12265-013-9507-7. Epub 2013 Aug 28.
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Procedural safety and predictors of acute outcome of intracoronary administration of progenitor cells in 775 consecutive procedures performed for acute myocardial infarction or chronic heart failure.
De Rosa S, Seeger FH, Honold J, Fischer-Rasokat U, Lehmann R, Fichtlscherer S, Schächinger V, Dimmeler S, Zeiher AM, Assmus B.
Circ Cardiovasc Interv. 2013 Feb;6(1):44-51. doi: 10.1161/CIRCINTERVENTIONS.112.971705. Epub 2013 Jan 29.
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Five-year results of intracoronary infusion of the mobilized peripheral blood stem cells by granulocyte colony-stimulating factor in patients with myocardial infarction.
Kang HJ, Kim MK, Lee HY, Park KW, Lee W, Cho YS, Koo BK, Choi DJ, Park YB, Kim HS.
Eur Heart J. 2012 Dec;33(24):3062-9. doi: 10.1093/eurheartj/ehs231. Epub 2012 Aug 17.
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Adventitial delivery of an allogeneic bone marrow-derived adherent stem cell in acute myocardial infarction: phase I clinical study.
Penn MS, Ellis S, Gandhi S, Greenbaum A, Hodes Z, Mendelsohn FO, Strasser D, Ting AE, Sherman W.
Circ Res. 2012 Jan 20;110(2):304-11. doi: 10.1161/CIRCRESAHA.111.253427. Epub 2011 Nov 3.
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Five-year results of intracoronary infusion of the mobilized peripheral blood stem cells by granulocyte colony-stimulating factor in patients with myocardial infarction.
Kang HJ, Kim MK, Lee HY, Park KW, Lee W, Cho YS, Koo BK, Choi DJ, Park YB, Kim HS.
Eur Heart J. 2012 Dec;33(24):3062-9. doi: 10.1093/eurheartj/ehs231. Epub 2012 Aug 17.
FREE ARTICLE

CD34(+) cell infusion after ST elevation myocardial infarction is associated with improved perfusion and is dose dependent.
Quyyumi AA, Waller EK, Murrow J, Esteves F, Galt J, Oshinski J, Lerakis S, Sher S, Vaughan D, Perin E, Willerson J, Kereiakes D, Gersh BJ, Gregory D, Werner A, Moss T, Chan WS, Preti R, Pecora AL.
Am Heart J. 2011 Jan;161(1):98-105. doi: 10.1016/j.ahj.2010.09.025.
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Safety and feasibility of combined granulocyte colony stimulating factor and erythropoetin based-stem cell therapy using intracoronary infusion of peripheral blood stem cells in patients with recent anterior myocardial infarction: one-year follow-up of a phase 1 study.
Santoso T, Irawan C, Alwi I, Aziz A, Kosasih A, Inggriani S, Saputra A, Wintery M, Lison L.
Acta Med Indones. 2011 Apr;43(2):112-21.
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Regional myocardial function after intracoronary bone marrow cell injection in reperfused anterior wall infarction - a cardiovascular magnetic resonance tagging study.
Hopp E, Lunde K, Solheim S, Aakhus S, Arnesen H, Forfang K, Edvardsen T, Smith HJ.
J Cardiovasc Magn Reson. 2011 Mar 17;13:22. doi: 10.1186/1532-429X-13-22.
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Influence of bone marrow stem cells on left ventricle perfusion and ejection fraction in patients with acute myocardial infarction of anterior wall: randomized clinical trial: Impact of bone marrow stem cell intracoronary infusion on improvement of microcirculation.
Grajek S, Popiel M, Gil L, Breborowicz P, Lesiak M, Czepczyński R, Sawiński K, Straburzyńska-Migaj E, Araszkiewicz A, Czyz A, Kozłowska-Skrzypczak M, Komarnicki M.
Eur Heart J. 2010 Mar;31(6):691-702. doi: 10.1093/eurheartj/ehp536. Epub 2009 Dec 17.
FREE ARTICLE

Results of a phase 1, randomized, double-blind, placebo-controlled trial of bone marrow mononuclear stem cell administration in patients following ST-elevation myocardial infarction.
Traverse JH, McKenna DH, Harvey K, Jorgenso BC, Olson RE, Bostrom N, Kadidlo D, Lesser JR, Jagadeesan V, Garberich R, Henry TD.
Am Heart J. 2010 Sep;160(3):428-34. doi: 10.1016/j.ahj.2010.06.009.
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Clinical outcome 2 years after intracoronary administration of bone marrow-derived progenitor cells in acute myocardial infarction.
Assmus B, Rolf A, Erbs S, Elsässer A, Haberbosch W, Hambrecht R, Tillmanns H, Yu J, Corti R, Mathey DG, Hamm CW, Süselbeck T, Tonn T, Dimmeler S, Dill T, Zeiher AM, Schächinger V; REPAIR-AMI Investigators.
Circ Heart Fail. 2010 Jan;3(1):89-96. doi: 10.1161/CIRCHEARTFAILURE.108.843243. Epub 2009 Dec 8.
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Intracoronary infusion of bone marrow-derived selected CD34+CXCR4+ cells and non-selected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: results of randomized, multicentre Myocardial Regeneration by Intracoronary Infusion of Selected Population of Stem Cells in Acute Myocardial Infarction (REGENT) Trial.
Tendera M, Wojakowski W, Ruzyłło W, Chojnowska L, Kepka C, Tracz W, Musiałek P, Piwowarska W, Nessler J, Buszman P, Grajek S, Breborowicz P, Majka M, Ratajczak MZ; REGENT Investigators.
Eur Heart J. 2009 Jun;30(11):1313-21. doi: 10.1093/eurheartj/ehp073. Epub 2009 Feb 10.
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Results of intracoronary stem cell therapy after acute myocardial infarction.
Wöhrle J, Merkle N, Mailänder V, Nusser T, Schauwecker P, von Scheidt F, Schwarz K, Bommer M, Wiesneth M, Schrezenmeier H, Hombach V.
Am J Cardiol. 2010 Mar 15;105(6):804-12. doi: 10.1016/j.amjcard.2009.10.060.
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Effect of intracoronary injection of mononuclear bone marrow stem cells on left ventricular function in patients with acute myocardial infarction.
Plewka M, Krzemińska-Pakuła M, Lipiec P, Peruga JZ, Jezewski T, Kidawa M, Wierzbowska-Drabik K, Korycka A, Robak T, Kasprzak JD.
Am J Cardiol. 2009 Nov 15;104(10):1336-42. doi: 10.1016/j.amjcard.2009.06.057. Epub 2009 Sep 25.
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Restoration of microvascular function in the infarct-related artery by intracoronary transplantation of bone marrow progenitor cells in patients with acute myocardial infarction: the Doppler Substudy of the Reinfusion of Enriched Progenitor Cells and Infarct Remodeling in Acute Myocardial Infarction (REPAIR-AMI) trial.
Erbs S, Linke A, Schächinger V, Assmus B, Thiele H, Diederich KW, Hoffmann C, Dimmeler S, Tonn T, Hambrecht R, Zeiher AM, Schuler G.
Circulation. 2007 Jul 24;116(4):366-74. Epub 2007 Jul 9.
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Improved regional function after autologous bone marrow-derived stem cell transfer in patients with acute myocardial infarction: a randomized, double-blind strain rate imaging study.
Herbots L, D'hooge J, Eroglu E, Thijs D, Ganame J, Claus P, Dubois C, Theunissen K, Bogaert J, Dens J, Kalantzi M, Dymarkowski S, Bijnens B, Belmans A, Boogaerts M, Sutherland G, Van de Werf F, Rademakers F, Janssens S.
Eur Heart J. 2009 Mar;30(6):662-70. doi: 10.1093/eurheartj/ehn532. Epub 2008 Dec 23.
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Long-term myocardial functional improvement after autologous bone marrow mononuclear cells transplantation in patients with ST-segment elevation myocardial infarction: 4 years follow-up.
Cao F, Sun D, Li C, Narsinh K, Zhao L, Li X, Feng X, Zhang J, Duan Y, Wang J, Liu D, Wang H.
Eur Heart J. 2009 Aug;30(16):1986-94. doi: 10.1093/eurheartj/ehp220. Epub 2009 Jun 9.
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Intracoronary transplantation of non-expanded peripheral blood-derived mononuclear cells promotes improvement of cardiac function in patients with acute myocardial infarction.
Tatsumi T, Ashihara E, Yasui T, Matsunaga S, Kido A, Sasada Y, Nishikawa S, Hadase M, Koide M, Nakamura R, Irie H, Ito K, Matsui A, Matsui H, Katamura M, Kusuoka S, Matoba S, Okayama S, Horii M, Uemura S, Shimazaki C, Tsuji H, Saito Y, Matsubara H.
Circ J. 2007 Aug;71(8):1199-207. Erratum in: Circ J. 2014 Mar;78(3):777-9.
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Impact of intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction on left ventricular perfusion and function: a 6-month follow-up gated 99mTc-MIBI single-photon emission computed tomography study.
Lipiec P, Krzemińska-Pakuła M, Plewka M, Kuśmierek J, Płachcińska A, Szumiński R, Robak T, Korycka A, Kasprzak JD.
Eur J Nucl Med Mol Imaging. 2009 Apr;36(4):587-93. doi: 10.1007/s00259-008-0988-6. Epub 2008 Nov 29.
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Bone marrow derived mesenchymal cell mobilization by granulocyte-colony stimulating factor after acute myocardial infarction: results from the Stem Cells in Myocardial Infarction (STEMMI) trial.
Ripa RS, Haack-Sørensen M, Wang Y, Jørgensen E, Mortensen S, Bindslev L, Friis T, Kastrup J.
Circulation. 2007 Sep 11;116(11 Suppl):I24-30.
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Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: final 1-year results of the REPAIR-AMI trial.
Schächinger V, Erbs S, Elsässer A, Haberbosch W, Hambrecht R, Hölschermann H, Yu J, Corti R, Mathey DG, Hamm CW, Süselbeck T, Werner N, Haase J, Neuzner J, Germing A, Mark B, Assmus B, Tonn T, Dimmeler S, Zeiher AM; REPAIR-AMI Investigators.
Eur Heart J. 2006 Dec;27(23):2775-83. Epub 2006 Nov 10.
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Transcoronary transplantation of progenitor cells after myocardial infarction.
Assmus B, Honold J, Schächinger V, Britten MB, Fischer-Rasokat U, Lehmann R, Teupe C, Pistorius K, Martin H, Abolmaali ND, Tonn T, Dimmeler S, Zeiher AM.
N Engl J Med. 2006 Sep 21;355(12):1222-32.
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The impact of the capability of circulating progenitor cell to differentiate on myocardial salvage in patients with primary acute myocardial infarction.
Numaguchi Y, Sone T, Okumura K, Ishii M, Morita Y, Kubota R, Yokouchi K, Imai H, Harada M, Osanai H, Kondo T, Murohara T.
Circulation. 2006 Jul 4;114(1 Suppl):I114-9.
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Efficacy of emergent transcatheter transplantation of stem cells for treatment of acute myocardial infarction (TCT-STAMI).
Ge J, Li Y, Qian J, Shi J, Wang Q, Niu Y, Fan B, Liu X, Zhang S, Sun A, Zou Y.
Heart. 2006 Dec;92(12):1764-7. Epub 2006 Jun 14.
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Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction.
Lunde K, Solheim S, Aakhus S, Arnesen H, Abdelnoor M, Egeland T, Endresen K, Ilebekk A, Mangschau A, Fjeld JG, Smith HJ, Taraldsrud E, Grøgaard HK, Bjørnerheim R, Brekke M, Müller C, Hopp E, Ragnarsson A, Brinchmann JE, Forfang K.
N Engl J Med. 2006 Sep 21;355(12):1199-209.
FREE ARTICLE

Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction.
Schächinger V, Erbs S, Elsässer A, Haberbosch W, Hambrecht R, Hölschermann H, Yu J, Corti R, Mathey DG, Hamm CW, Süselbeck T, Assmus B, Tonn T, Dimmeler S, Zeiher AM; REPAIR-AMI Investigators.
N Engl J Med. 2006 Sep 21;355(12):1210-21.
FREE ARTICLE

Intracoronary injection of CD133-positive enriched bone marrow progenitor cells promotes cardiac recovery after recent myocardial infarction: feasibility and safety.
Bartunek J, Vanderheyden M, Vandekerckhove B, Mansour S, De Bruyne B, De Bondt P, Van Haute I, Lootens N, Heyndrickx G, Wijns W.
Circulation. 2005 Aug 30;112(9 Suppl):I178-83.
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Experimental and clinical regenerative capability of human bone marrow cells after myocardial infarction.
Fernández-Avilés F, San Román JA, García-Frade J, Fernández ME, Peñarrubia MJ, de la Fuente L, Gómez-Bueno M, Cantalapiedra A, Fernández J, Gutierrez O, Sánchez PL, Hernández C, Sanz R, García-Sancho J, Sánchez A.
Circ Res. 2004 Oct 1;95(7):742-8. Epub 2004 Sep 9.
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Improvement of cardiac function after transplantation of autologous bone marrow mesenchymal stem cells in patients with acute myocardial infarction.
Chen SL, Fang WW, Qian J, Ye F, Liu YH, Shan SJ, Zhang JJ, Lin S, Liao LM, Zhao RC.
Chin Med J (Engl). 2004 Oct;117(10):1443-8. Erratum in: Chin Med J (Engl). 2005 Jan 5;118(1):88.
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Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI).
Assmus B, Schächinger V, Teupe C, Britten M, Lehmann R, Döbert N, Grünwald F, Aicher A, Urbich C, Martin H, Hoelzer D, Dimmeler S, Zeiher AM.
Circulation. 2002 Dec 10;106(24):3009-17.
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Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: results of 3 randomized studies.
Sandri M, Adams V, Gielen S, Linke A, Lenk K, Kränkel N, Lenz D, Erbs S, Scheinert D, Mohr FW, Schuler G, Hambrecht R.
Circulation. 2005 Jun 28;111(25):3391-9. Epub 2005 Jun 13.
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Left ventricular systolic and diastolic function improve after acute myocardial infarction treated with acute percutaneous coronary intervention, but are not influenced by intracoronary injection of autologous mononuclear bone marrow cells: a 3 year serial echocardiographic sub-study of the randomized-controlled ASTAMI study.
Beitnes JO, Gjesdal O, Lunde K, Solheim S, Edvardsen T, Arnesen H, Forfang K, Aakhus S.
Eur J Echocardiogr. 2011 Feb;12(2):98-106. doi: 10.1093/ejechocard/jeq116. Epub 2010 Sep 17.
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LateTIME: a phase-II, randomized, double-blinded, placebo-controlled, pilot trial evaluating the safety and effect of administration of bone marrow mononuclear cells 2 to 3 weeks after acute myocardial infarction.
Traverse JH, Henry TD, Vaughan DE, Ellis SG, Pepine CJ, Willerson JT, Zhao DX, Simpson LM, Penn MS, Byrne BJ, Perin EC, Gee AP, Hatzopoulos AK, McKenna DH, Forder JR, Taylor DA, Cogle CR, Baraniuk S, Olson RE, Jorgenson BC, Sayre SL, Vojvodic RW, Gordon DJ, Skarlatos SI, Moyè LA, Simari RD; Cardiovascular Cell Therapy Research Network.
Tex Heart Inst J. 2010;37(4):412-20.
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Combined delivery approach of bone marrow mononuclear stem cells early and late after myocardial infarction: the MYSTAR prospective, randomized study.
Gyöngyösi M, Lang I, Dettke M, Beran G, Graf S, Sochor H, Nyolczas N, Charwat S, Hemetsberger R, Christ G, Edes I, Balogh L, Krause KT, Jaquet K, Kuck KH, Benedek I, Hintea T, Kiss R, Préda I, Kotevski V, Pejkov H, Zamini S, Khorsand A, Sodeck G, Kaider A, Maurer G, Glogar D.
Nat Clin Pract Cardiovasc Med. 2009 Jan;6(1):70-81. doi: 10.1038/ncpcardio1388. Epub 2008 Nov 11.

Transplanted human cord blood-derived unrestricted somatic stem cells improve left-ventricular function and prevent left-ventricular dilation and scar formation after acute myocardial infarction.
Ghodsizad A, Niehaus M, Kögler G, Martin U, Wernet P, Bara C, Khaladj N, Loos A, Makoui M, Thiele J, Mengel M, Karck M, Klein HM, Haverich A, Ruhparwar A.
Heart. 2009 Jan;95(1):27-35. doi: 10.1136/hrt.2007.139329. Epub 2008 Jun 2.

Intracoronary administration of bone marrow-derived progenitor cells improves left ventricular function in patients at risk for adverse remodeling after acute ST-segment elevation myocardial infarction: results of the Reinfusion of Enriched Progenitor cells And Infarct Remodeling in Acute Myocardial Infarction study (REPAIR-AMI) cardiac magnetic resonance imaging substudy.
Dill T, Schächinger V, Rolf A, Möllmann S, Thiele H, Tillmanns H, Assmus B, Dimmeler S, Zeiher AM, Hamm C.
Am Heart J. 2009 Mar;157(3):541-7. doi: 10.1016/j.ahj.2008.11.011. Epub 2009 Jan 31.

Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial.
Makkar RR, Smith RR, Cheng K, Malliaras K, Thomson LE, Berman D, Czer LS, Marbán L, Mendizabal A, Johnston PV, Russell SD, Schuleri KH, Lardo AC, Gerstenblith G, Marbán E.
Lancet. 2012 Mar 10;379(9819):895-904. doi: 10.1016/S0140-6736(12)60195-0. Epub 2012 Feb 14.

Percutaneous intramyocardial stem cell injection in patients with acute myocardial infarction: first-in-man study.
Krause K, Jaquet K, Schneider C, Haupt S, Lioznov MV, Otte KM, Kuck KH.
Heart. 2009 Jul;95(14):1145-52. doi: 10.1136/hrt.2008.155077. Epub 2009 Mar 30.

Long-term results after intracoronary injection of autologous mononuclear bone marrow cells in acute myocardial infarction: the ASTAMI randomised, controlled study.
Beitnes JO, Hopp E, Lunde K, Solheim S, Arnesen H, Brinchmann JE, Forfang K, Aakhus S.
Heart. 2009 Dec;95(24):1983-9. doi: 10.1136/hrt.2009.178913. Epub 2009 Oct 14.

Intracoronary infusion of bone marrow-derived mononuclear cells abrogates adverse left ventricular remodelling post-acute myocardial infarction: insights from the reinfusion of enriched progenitor cells and infarct remodelling in acute myocardial infarction (REPAIR-AMI) trial.
Schächinger V, Assmus B, Erbs S, Elsässer A, Haberbosch W, Hambrecht R, Yu J, Corti R, Mathey DG, Hamm CW, Tonn T, Dimmeler S, Zeiher AM; REPAIR-AMI investigators.
Eur J Heart Fail. 2009 Oct;11(10):973-9. doi: 10.1093/eurjhf/hfp113.

Determinants of functional recovery after myocardial infarction of patients treated with bone marrow-derived stem cells after thrombolytic therapy.
Miettinen JA, Ylitalo K, Hedberg P, Jokelainen J, Kervinen K, Niemelä M, Säily M, Koistinen P, Savolainen ER, Ukkonen H, Pietilä M, Airaksinen KE, Knuuti J, Vuolteenaho O, Mäkikallio TH, Huikuri HV.
Heart. 2010 Mar;96(5):362-7. doi: 10.1136/hrt.2009.171694. Epub 2009 Nov 11.

Bone marrow cell transplantation improves cardiac, autonomic, and functional indexes in acute anterior myocardial infarction patients (Cardiac Study).
Piepoli MF, Vallisa D, Arbasi M, Cavanna L, Cerri L, Mori M, Passerini F, Tommasi L, Rossi A, Capucci A; Cardiac Study Group.
Eur J Heart Fail. 2010 Feb;12(2):172-80. doi: 10.1093/eurjhf/hfp183. Epub 2009 Dec 30.

Maladaptive hypertrophy after acute myocardial infarction positive effect of bone marrow-derived stem cell therapy on regional remodeling measured by cardiac MRI.
Rolf A, Assmus B, Schächinger V, Rixe J, Möllmann S, Möllmann H, Dimmeler S, Zeiher AM, Hamm CW, Dill T.
Clin Res Cardiol. 2011 Nov;100(11):983-92. doi: 10.1007/s00392-011-0330-3. Epub 2011 Jun 17.

Effect of intramyocardial delivery of autologous bone marrow mononuclear stem cells on the regional myocardial perfusion. NOGA-guided subanalysis of the MYSTAR prospective randomised study.
Charwat S, Lang I, Dettke M, Graf S, Nyolczas N, Hemetsberger R, Zamini S, Khorsand A, Sochor H, Maurer G, Glogar D, Gyöngyösi M.
Thromb Haemost. 2010 Mar;103(3):564-71. doi: 10.1160/TH09-08-0520. Epub 2010 Jan 13.

Intra-coronary bone marrow mononuclear cell transplantation in patients with ST-elevation myocardial infarction: a randomized controlled study.
Srimahachota S, Boonyaratavej S, Rerkpattanapipat P, Wangsupachart S, Tumkosit M, Bunworasate U, Nakorn TN, Intragumtornchai T, Kupatawintu P, Pongam S, Saengsiri AO, Pothisri M, Sukseri Y, Bunprasert T, Suithichaiyakul T.
J Med Assoc Thai. 2011 Jun;94(6):657-63.

Absence of accelerated atherosclerotic disease progression after intracoronary infusion of bone marrow derived mononuclear cells in patients with acute myocardial infarction--angiographic and intravascular ultrasound--results from the TErapia Celular Aplicada al Miocardio Pilot study.
Arnold R, Villa A, Gutiérrez H, Sánchez PL, Gimeno F, Fernández ME, Gutiérrez O, Mota P, Sánchez A, García-Frade J, Fernández-Avilés F, San Román JA; TECAM (TErapia Celular Aplicada al Miocardio) research group.
Am Heart J. 2010 Jun;159(6):1154.e1-8. doi: 10.1016/j.ahj.2010.03.030.

Impact of preoperative left ventricular function and time from infarction on the long-term benefits after intramyocardial CD133(+) bone marrow stem cell transplant.
Yerebakan C, Kaminski A, Westphal B, Donndorf P, Glass A, Liebold A, Stamm C, Steinhoff G.
J Thorac Cardiovasc Surg. 2011 Dec;142(6):1530-9.e3. doi: 10.1016/j.jtcvs.2011.05.002. Epub 2011 Jun 12.

Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI): final 5-year results suggest long-term safety and efficacy.
Leistner DM, Fischer-Rasokat U, Honold J, Seeger FH, Schächinger V, Lehmann R, Martin H, Burck I, Urbich C, Dimmeler S, Zeiher AM, Assmus B.
Clin Res Cardiol. 2011 Oct;100(10):925-34. doi: 10.1007/s00392-011-0327-y. Epub 2011 Jun 3.

Myocardial blood flow and infarct size after CD133+ cell injection in large myocardial infarction with good recanalization and poor reperfusion: results from a randomized controlled trial.
Colombo A, Castellani M, Piccaluga E, Pusineri E, Palatresi S, Longari V, Canzi C, Sacchi E, Rossi E, Rech R, Gerundini P, Viecca M, Deliliers GL, Rebulla P, Soligo D, Giordano R.
J Cardiovasc Med (Hagerstown). 2011 Apr;12(4):239-48. doi: 10.2459/JCM.0b013e328343d708

The influence of intracoronary injection of bone marrow cells on prothrombotic markers in patients with acute myocardial infarction.
Solheim S, Seljeflot I, Lunde K, Bratseth V, Aakhus S, Forfang K, Arnesen H.
Thromb Res. 2012 Nov;130(5):765-8. doi: 10.1016/j.thromres.2011.11.045. Epub 2011 Dec 20.

One-year follow-up of intracoronary stem cell delivery on left ventricular function following ST-elevation myocardial infarction.
Traverse JH, Henry TD, Pepine CJ, Willerson JT, Ellis SG.
JAMA. 2014 Jan 15;311(3):301-2. doi: 10.1001/jama.2013.282674.

Intracoronary cardiosphere-derived cells after myocardial infarction: evidence of therapeutic regeneration in the final 1-year results of the CADUCEUS trial (CArdiosphere-Derived aUtologousstem CElls to reverse ventricUlardySfunction).
Malliaras K, Makkar RR, Smith RR, Cheng K, Wu E, Bonow RO, Marbán L, Mendizabal A, Cingolani E, Johnston PV, Gerstenblith G, Schuleri KH, Lardo AC, Marbán E.
J Am CollCardiol. 2014 Jan 21;63(2):110-22. doi: 10.1016/j.jacc.2013.08.724. Epub 2013 Sep 11.

Impact of cell number and microvascular obstruction in patients with bone-marrow derived cell therapy: final results from the randomized, double-blind, placebo controlled intracoronary Stem Cell therapy in patients with Acute Myocardial Infarction (SCAMI) trial.
Wöhrle J, von Scheidt F, Schauwecker P, Wiesneth M, Markovic S, Schrezenmeier H, Hombach V, Rottbauer W, Bernhardt P.
Clin Res Cardiol. 2013 Oct;102(10):765-70. doi: 10.1007/s00392-013-0595-9. Epub 2013 Jul 30.

Implantation of CD133+ stem cells in patients undergoing coronary bypass surgery: IMPACT-CABG pilot trial.
Forcillo J, Stevens LM, Mansour S, Prieto I, Salem R, Baron C, Roy DC, Larose E, Masckauchan D, Noiseux N.
Can J Cardiol. 2013 Apr;29(4):441-7. doi: 10.1016/j.cjca.2012.08.009. Epub 2012 Dec 21.

Autologous mesenchymal stem cells produce concordant improvements in regional function, tissue perfusion, and fibrotic burden when administered to patients undergoing coronary artery bypass grafting: The Prospective Randomized Study of Mesenchymal Stem Cell Therapy in Patients Undergoing Cardiac Surgery (PROMETHEUS) trial.
Karantalis V, DiFede DL, Gerstenblith G, Pham S, Symes J, Zambrano JP, Fishman J, Pattany P, McNiece I, Conte J, Schulman S, Wu K, Shah A, Breton E, Davis-Sproul J, Schwarz R, Feigenbaum G, Mushtaq M, Suncion VY, Lardo AC, Borrello I, Mendizabal A, Karas TZ, Byrnes J, Lowery M, Heldman AW, Hare JM.
Circ Res. 2014 Apr 11;114(8):1302-10. doi: 10.1161/CIRCRESAHA.114.303180. Epub 2014 Feb 24.

A phase 3, randomized, double-blinded, active-controlled, unblinded standard of care study assessing the efficacy and safety of intramyocardial autologous CD34+ cell administration in patients with refractory angina: design of the RENEW study.
Povsic TJ, Junge C, Nada A, Schatz RA, Harrington RA, Davidson CJ, Fortuin FD, Kereiakes DJ, Mendelsohn FO, Sherman W, Schaer GL, White CJ, Stewart D, Story K, Losordo DW, Henry TD.
Am Heart J. 2013 Jun;165(6):854-861.e2. doi: 10.1016/j.ahj.2013.03.003. Epub 2013 Apr 19.


PRECLINICAL STUDIES

Priming with ligands secreted by human stromal progenitor cells promotes grafts of cardiac stem/progenitor cells after myocardial infarction.
Iso Y, Rao KS, Poole CN, Zaman AK, Curril I, Sobel BE, Kajstura J, Anversa P, Spees JL.
Stem Cells. 2014 Mar;32(3):674-83. doi: 10.1002/stem.1546.
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Transplantation of expanded bone marrow-derived very small embryonic-like stem cells (VSEL-SCs) improves left ventricular function and remodelling after myocardial infarction.
Zuba-Surma EK, Guo Y, Taher H, Sanganalmath SK, Hunt G, Vincent RJ, Kucia M, Abdel-Latif A, Tang XL, Ratajczak MZ, Dawn B, Bolli R.
J Cell Mol Med. 2011 Jun;15(6):1319-28. doi: 10.1111/j.1582-4934.2010.01126.x. Epub 2010 Jul 12.
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The ephrin A1-EphA2 system promotes cardiac stem cell migration after infarction.
Goichberg P, Bai Y, D'Amario D, Ferreira-Martins J, Fiorini C, Zheng H, Signore S, del Monte F, Ottolenghi S, D'Alessandro DA, Michler RE, Hosoda T, Anversa P, Kajstura J, Rota M, Leri A.
Circ Res. 2011 Apr 29;108(9):1071-83. doi: 10.1161/CIRCRESAHA.110.239459. Epub 2011 Mar 17.
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Human cardiac stem cell differentiation is regulated by a mircrine mechanism.
Hosoda T, Zheng H, Cabral-da-Silva M, Sanada F, Ide-Iwata N, Ogórek B, Ferreira-Martins J, Arranto C, D'Amario D, del Monte F, Urbanek K, D'Alessandro DA, Michler RE, Anversa P, Rota M, Kajstura J, Leri A.
Circulation. 2011 Mar 29;123(12):1287-96. doi: 10.1161/CIRCULATIONAHA.110.982918. Epub 2011 Mar 14.
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Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction.
Tang XL, Rokosh G, Sanganalmath SK, Yuan F, Sato H, Mu J, Dai S, Li C, Chen N, Peng Y, Dawn B, Hunt G, Leri A, Kajstura J, Tiwari S, Shirk G, Anversa P, Bolli R.
Circulation. 2010 Jan 19;121(2):293-305. doi: 10.1161/CIRCULATIONAHA.109.871905. Epub 2010 Jan 4.
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Transplantation of bone marrow-derived very small embryonic-like stem cells attenuates left ventricular dysfunction and remodeling after myocardial infarction.
Dawn B, Tiwari S, Kucia MJ, Zuba-Surma EK, Guo Y, Sanganalmath SK, Abdel-Latif A, Hunt G, Vincent RJ, Taher H, Reed NJ, Ratajczak MZ, Bolli R.
Stem Cells. 2008 Jun;26(6):1646-55. doi: 10.1634/stemcells.2007-0715. Epub 2008 Apr 17.
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Cardiac progenitor cells and biotinylated insulin-like growth factor-1 nanofibers improve endogenous and exogenous myocardial regeneration after infarction.
Padin-Iruegas ME, Misao Y, Davis ME, Segers VF, Esposito G, Tokunou T, Urbanek K, Hosoda T, Rota M, Anversa P, Leri A, Lee RT, Kajstura J.
Circulation. 2009 Sep 8;120(10):876-87. doi: 10.1161/CIRCULATIONAHA.109.852285. Epub 2009 Aug 24.
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Autologous bone marrow-derived mononuclear cell therapy prevents the damage of viable myocardium and improves rat heart function following acute anterior myocardial infarction.
Yip HK, Chang LT, Wu CJ, Sheu JJ, Youssef AA, Pei SN, Lee FY, Sun CK.
Circ J. 2008 Aug;72(8):1336-45.
Free Article

Xenotransplantation of long-term-cultured swine bone marrow-derived mesenchymal stem cells.
Nakamura Y, Wang X, Xu C, Asakura A, Yoshiyama M, From AH, Zhang J.
Stem Cells. 2007 Mar;25(3):612-20. Epub 2006 Nov 9.
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Bioenergetic and functional consequences of bone marrow-derived multipotent progenitor cell transplantation in hearts with postinfarction left ventricular remodeling.
Zeng L, Hu Q, Wang X, Mansoor A, Lee J, Feygin J, Zhang G, Suntharalingam P, Boozer S, Mhashilkar A, Panetta CJ, Swingen C, Deans R, From AH, Bache RJ, Verfaillie CM, Zhang J.
Circulation. 2007 Apr 10;115(14):1866-75. Epub 2007 Mar 26.
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Bcl-2 engineered MSCs inhibited apoptosis and improved heart function.
Li W, Ma N, Ong LL, Nesselmann C, Klopsch C, Ladilov Y, Furlani D, Piechaczek C, Moebius JM, Lützow K, Lendlein A, Stamm C, Li RK, Steinhoff G.
Stem Cells. 2007 Aug;25(8):2118-27. Epub 2007 May 3.
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Bone marrow cells adopt the cardiomyogenic fate in vivo.
Rota M, Kajstura J, Hosoda T, Bearzi C, Vitale S, Esposito G, Iaffaldano G, Padin-Iruegas ME, Gonzalez A, Rizzi R, Small N, Muraski J, Alvarez R, Chen X, Urbanek K, Bolli R, Houser SR, Leri A, Sussman MA, Anversa P.
Proc Natl Acad Sci U S A. 2007 Nov 6;104(45):17783-8. Epub 2007 Oct 26.
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Cardiac stem cells delivered intravascularly traverse the vessel barrier, regenerate infarcted myocardium, and improve cardiac function.
Dawn B, Stein AB, Urbanek K, Rota M, Whang B, Rastaldo R, Torella D, Tang XL, Rezazadeh A, Kajstura J, Leri A, Hunt G, Varma J, Prabhu SD, Anversa P, Bolli R.
ProcNatlAcadSci U S A. 2005 Mar 8;102(10):3766-71. Epub 2005 Feb 25.
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Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction.
Amado LC, Saliaris AP, Schuleri KH, St John M, Xie JS, Cattaneo S, Durand DJ, Fitton T, Kuang JQ, Stewart G, Lehrke S, Baumgartner WW, Martin BJ, Heldman AW, Hare JM.
Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11474-9. Epub 2005 Aug 1.
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Intracoronary administration of autologous adipose tissue-derived stem cells improves left ventricular function, perfusion, and remodelling after acute myocardial infarction.
Valina C, Pinkernell K, Song YH, Bai X, Sadat S, Campeau RJ, Le Jemtel TH, Alt E.
Eur Heart J. 2007 Nov;28(21):2667-77. Epub 2007 Oct 11.
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Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion.
Kajstura J, Rota M, Whang B, Cascapera S, Hosoda T, Bearzi C, Nurzynska D, Kasahara H, Zias E, Bonafé M, Nadal-Ginard B, Torella D, Nascimbene A, Quaini F, Urbanek K, Leri A, Anversa P.
Circ Res. 2005 Jan 7;96(1):127-37. Epub 2004 Nov 29.
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Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction.
Yoon YS, Wecker A, Heyd L, Park JS, Tkebuchava T, Kusano K, Hanley A, Scadova H, Qin G, Cha DH, Johnson KL, Aikawa R, Asahara T, Losordo DW.
J Clin Invest. 2005 Feb;115(2):326-38.
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Repair of infarcted myocardium mediated by transplanted bone marrow-derived CD34+ stem cells in a nonhuman primate model.
Yoshioka T, Ageyama N, Shibata H, Yasu T, Misawa Y, Takeuchi K, Matsui K, Yamamoto K, Terao K, Shimada K, Ikeda U, Ozawa K, Hanazono Y.
Stem Cells. 2005 Mar;23(3):355-64.
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Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis.
Nagaya N, Fujii T, Iwase T, Ohgushi H, Itoh T, Uematsu M, Yamagishi M, Mori H, Kangawa K, Kitamura S.
Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2670-6. Epub 2004 Jul 29.
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Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts.
Mangi AA, Noiseux N, Kong D, He H, Rezvani M, Ingwall JS, Dzau VJ.
Nat Med. 2003 Sep;9(9):1195-201. Epub 2003 Aug 10.
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Mesenchymal progenitor cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a rat cellular cardiomyoplasty model.
Davani S, Marandin A, Mersin N, Royer B, Kantelip B, Hervé P, Etievent JP, Kantelip JP.
Circulation. 2003 Sep 9;108 Suppl 1:II253-8.
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Cells expressing early cardiac markers reside in the bone marrow and are mobilized into the peripheral blood after myocardial infarction.
Kucia M, Dawn B, Hunt G, Guo Y, Wysoczynski M, Majka M, Ratajczak J, Rezzoug F, Ildstad ST, Bolli R, Ratajczak MZ.
Circ Res. 2004 Dec 10;95(12):1191-9. Epub 2004 Nov 18.
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Experimental and clinical regenerative capability of human bone marrow cells after myocardial infarction.
Fernández-Avilés F, San Román JA, García-Frade J, Fernández ME, Peñarrubia MJ, de la Fuente L, Gómez-Bueno M, Cantalapiedra A, Fernández J, Gutierrez O, Sánchez PL, Hernández C, Sanz R, García-Sancho J, Sánchez A.
Circ Res. 2004 Oct 1;95(7):742-8. Epub 2004 Sep 9.
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Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells.
Jackson KA, Majka SM, Wang H, Pocius J, Hartley CJ, Majesky MW, Entman ML, Michael LH, Hirschi KK, Goodell MA.
J Clin Invest. 2001 Jun;107(11):1395-402.
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Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment.
Iso Y, Spees JL, Serrano C, Bakondi B, Pochampally R, Song YH, Sobel BE, Delafontaine P, Prockop DJ.
Biochem Biophys Res Commun. 2007 Mar 16;354(3):700-6. Epub 2007 Jan 17.
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Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis.
Nagaya N, Fujii T, Iwase T, Ohgushi H, Itoh T, Uematsu M, Yamagishi M, Mori H, Kangawa K, Kitamura S.
Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2670-6. Epub 2004 Jul 29.
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Myocardial neovascularization by bone marrow angioblasts results in cardiomyocyte regeneration.
Schuster MD, Kocher AA, Seki T, Martens TP, Xiang G, Homma S, Itescu S.
Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H525-32.
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c-kit+ Cardiac Stem Cells Alleviate Post-Myocardial Infarction Left Ventricular Dysfunction Despite Poor Engraftment and Negligible Retention in the Recipient Heart.
Hong KU, Guo Y, Li QH, Cao P, Al-Maqtari T, Vajravelu BN, Du J, Book MJ, Zhu X, Nong Y, Bhatnagar A, Bolli R.
PLoS One. 2014 May 7;9(5):e96725. doi: 10.1371/journal.pone.0096725. eCollection 2014.
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Mobilized bone marrow cells repair the infarcted heart, improving function and survival.
Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F, Nadal-Ginard B, Bodine DM, Leri A, Anversa P.
Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10344-9. Epub 2001 Aug 14.
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Review Articles

Adult bone marrow-derived cells: regenerative potential, plasticity, and tissue commitment.
Dawn B, Bolli R.
Basic Res Cardiol. 2005 Nov;100(6):494-503. Review.
Free Article

Cardiac stem cells and mechanisms of myocardial regeneration.
Leri A, Kajstura J, Anversa P.
Physiol Rev. 2005 Oct;85(4):1373-416. Review.
Free Article

Cell-based therapy of myocardial infarction.
Dimmeler S, Burchfield J, Zeiher AM.
Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):208-16. Epub 2007 Oct 19. Review.
Free Article

Very small embryonic-like stem cells: biology and therapeutic potential for heart repair.
Zuba-Surma EK, Wojakowski W, Ratajczak MZ, Dawn B.
Antioxid Redox Signal. 2011 Oct 1;15(7):1821-34. doi: 10.1089/ars.2010.3817. Epub 2011 May 5. Review.
FREE ARTICLE

Cell therapy with bone marrow cells for myocardial regeneration.
Kim H, Kim SW, Nam D, Kim S, Yoon YS.
Antioxid Redox Signal. 2009 Aug;11(8):1897-911. doi: 10.1089/ARS.2009.2486. Review.
Free Article

Cardiac cellular reprogramming.
Rosengart TK.
Tex Heart Inst J. 2013;40(5):581-2. No abstract available.
FREE ARTICLE

Mesenchymal stem cells for regenerative therapy: optimization of cell preparation protocols.
Ikebe C, Suzuki K.
Biomed Res Int. 2014;2014:951512. doi: 10.1155/2014/951512. Epub 2014 Jan 6.
FREE ARTICLE

Tracking of stem cells in vivo for cardiovascular applications.
Azene N, Fu Y, Maurer J, Kraitchman DL.
J Cardiovasc Magn Reson. 2014 Jan 10;16(1):7. doi: 10.1186/1532-429X-16-7.
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Last modified: Aug 20, 2014
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