Adult Stem Cells in Cancer

HUMAN STUDIES

 

Prognosis of patients with primary central nervous system lymphoma after high-dose chemotherapy followed by autologous stem cell transplantation.
Schorb E, Kasenda B, Atta J, Kaun S, Morgner A, Hess G, Elter T, von Bubnoff N, Dreyling M, Ringhoffer M, Krause SW, Derigs G, Klimm B, Niemann D, Fritsch K, Finke J, Illerhaus G.
Haematologica. 2013 May;98(5):765-70. doi: 10.3324/haematol.2012.076075. Epub 2013 Jan 8.
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Purged versus non-purged peripheral blood stem-cell transplantation for high-risk neuroblastoma (COG A3973): a randomised phase 3 trial.
Kreissman SG, Seeger RC, Matthay KK, London WB, Sposto R, Grupp SA, Haas-Kogan DA, Laquaglia MP, Yu AL, Diller L, Buxton A, Park JR, Cohn SL, Maris JM, Reynolds CP, Villablanca JG.
Lancet Oncol. 2013 Sep;14(10):999-1008. doi: 10.1016/S1470-2045(13)70309-7. Epub 2013 Jul 25.
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A pilot study of tandem high-dose chemotherapy with stem cell rescue as consolidation for high-risk neuroblastoma: Children's Oncology Group study ANBL00P1.
Seif AE, Naranjo A, Baker DL, Bunin NJ, Kletzel M, Kretschmar CS, Maris JM, McGrady PW, von Allmen D, Cohn SL, London WB, Park JR, Diller LR, Grupp SA.
Bone Marrow Transplant. 2013 Jul;48(7):947-52. doi: 10.1038/bmt.2012.276. Epub 2013 Jan 21.
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Phase II study of central nervous system (CNS)-directed chemotherapy including high-dose chemotherapy with autologous stem cell transplantation for CNS relapse of aggressive lymphomas.
Korfel A, Elter T, Thiel E, Hänel M, Möhle R, Schroers R, Reiser M, Dreyling M, Eucker J, Scholz C, Metzner B, Röth A, Birkmann J, Schlegel U, Martus P, Illerhaus G, Fischer L.
Haematologica. 2013 Mar;98(3):364-70. doi: 10.3324/haematol.2012.077917. Epub 2012 Dec 14.
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Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma.
Phuphanich S, Wheeler CJ, Rudnick JD, Mazer M, Wang H, Nuño MA, Richardson JE, Fan X, Ji J, Chu RM, Bender JG, Hawkins ES, Patil CG, Black KL, Yu JS.
Cancer ImmunolImmunother. 2013 Jan;62(1):125-35. doi: 10.1007/s00262-012-1319-0. Epub 2012 Jul 31.
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Long-term survival after high-dose chemotherapy followed by peripheral stem cell rescue for high-risk, locally advanced/inflammatory, and metastatic breast cancer.
VanderWalde A, Ye W, Frankel P, Asuncion D, Leong L, Luu T, Morgan R, Twardowski P, Koczywas M, Pezner R, Paz IB, Margolin K, Wong J, Doroshow JH, Forman S, Shibata S, Somlo G.
Biol Blood Marrow Transplant. 2012 Aug;18(8):1273-80. doi: 10.1016/j.bbmt.2012.01.021. Epub 2012 Feb 2.
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Adoptive transfer of autologous T cells improves T-cell repertoire diversity and long-term B-cell function in pediatric patients with neuroblastoma.
Grupp SA, Prak EL, Boyer J, McDonald KR, Shusterman S, Thompson E, Callahan C, Jawad AF, Levine BL, June CH, Sullivan KE.
Clin Cancer Res. 2012 Dec 15;18(24):6732-41. doi: 10.1158/1078-0432.CCR-12-1432. Epub 2012 Oct 23.
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PRECLINICAL STUDIES

IFN-γ-secreting-mesenchymal stem cells exert an antitumor effect in vivo via the TRAIL pathway.
Yang X, Du J, Xu X, Xu C, Song W.
J Immunol Res. 2014;2014:318098. doi: 10.1155/2014/318098. Epub 2014 May 26.
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Combinatorial control of transgene expression by hypoxia-responsive promoter and microrna regulation for neural stem cell-based cancer therapy.
Luo Y, Zhu D.
Biomed Res Int. 2014;2014:751397. doi: 10.1155/2014/751397. Epub 2014 Apr 17.
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Effect of NK4 transduction in bone marrow-derived mesenchymal stem cells on biological characteristics of pancreatic cancercells.
Sun YP, Zhang BL, Duan JW, Wu HH, Wang BQ, Yu ZP, Yang WJ, Shan YF, Zhou MT, Zhang QY.
Int J Mol Sci. 2014 Mar 3;15(3):3729-45. doi: 10.3390/ijms15033729.
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Gene therapy of ovarian cancer using IL-21-secreting human umbilical cord mesenchymal stem cells in nude mice.
Zhang Y, Wang J, Ren M, Li M, Chen D, Chen J, Shi F, Wang X, Dou J.
J Ovarian Res. 2014 Jan 20;7(1):8. doi: 10.1186/1757-2215-7-8.
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Neural stem cell-mediated delivery of irinotecan-activating carboxylesterases to glioma: implications for clinical use.
Metz MZ, Gutova M, Lacey SF, Abramyants Y, Vo T, Gilchrist M, Tirughana R, Ghoda LY, Barish ME, Brown CE, Najbauer J, Potter PM, Portnow J, Synold TW, Aboody KS.
Stem CellsTransl Med. 2013 Dec;2(12):983-92. doi: 10.5966/sctm.2012-0177. Epub 2013 Oct 28.
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Optimizing patient derived mesenchymal stem cells as virus carriers for a phase I clinical trial in ovarian cancer.
Mader EK, Butler G, Dowdy SC, Mariani A, Knutson KL, Federspiel MJ, Russell SJ, Galanis E, Dietz AB, Peng KW.
J Transl Med. 2013 Jan 24;11:20. doi: 10.1186/1479-5876-11-20.
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Mesenchymal stem cells derived from adipose tissue vs bone marrow: in vitro comparison of their tropism towards gliomas.
Pendleton C, Li Q, Chesler DA, Yuan K, Guerrero-Cazares H, Quinones-Hinojosa A.
PLoS One. 2013;8(3):e58198. doi: 10.1371/journal.pone.0058198. Epub 2013 Mar 12.
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Suppression of peritoneal tumorigenesis by placenta-derived mesenchymal stem cells expressing endostatin on colorectal cancer.
Zhang D, Zheng L, Shi H, Chen X, Wan Y, Zhang H, Li M, Lu L, Luo S, Yin T, Lin H, He S, Luo Y, Yang L.
Int J Med Sci. 2014 Jun 13;11(9):870-9. doi: 10.7150/ijms.8758. eCollection 2014.
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Conditioned media from human adipose tissue-derived mesenchymal stem cells and umbilical cord-derived mesenchymal stem cells efficiently induced the apoptosis and differentiation in human glioma cell lines in vitro.
Yang C, Lei D, Ouyang W, Ren J, Li H, Hu J, Huang S.
Biomed Res Int. 2014;2014:109389. doi: 10.1155/2014/109389. Epub 2014 May 27.
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Cancer cell-oriented migration of mesenchymal stem cells engineered with an anticancer gene (PTEN): an imaging demonstration.
Yang ZS, Tang XJ, Guo XR, Zou DD, Sun XY, Feng JB, Luo J, Dai LJ, Warnock GL.
Onco Targets Ther. 2014 Mar 17;7:441-6. doi: 10.2147/OTT.S59227. eCollection 2014.
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Umbilical cord tissue-derived mesenchymal stem cells induce apoptosis in PC-3 prostate cancer cells through activation of JNK and downregulation of PI3K/AKT signaling.
Han I, Yun M, Kim EO, Kim B, Jung MH, Kim SH.
Stem Cell Res Ther. 2014 Apr 16;5(2):54. [Epub ahead of print]
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REVIEW ARTICLES

Stem cells' guided gene therapy of cancer: New frontier in personalized and targeted therapy.
Mavroudi M, Zarogoulidis P, Porpodis K, Kioumis I, Lampaki S, Yarmus L, Malecki R, Zarogoulidis K, Malecki M.
J Cancer Res Ther (Manch). 2014;2(1):22-33.
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Clinical significance of epithelial-mesenchymal transition.
Steinestel K, Eder S, Schrader AJ, Steinestel J.
ClinTransl Med. 2014 Jul 2;3:17. doi: 10.1186/2001-1326-3-17. eCollection 2014. Review
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Role of BMSCs in liver regeneration and metastasis after hepatectomy.
Hang HL, Xia Q.
World J Gastroenterol. 2014 Jan 7;20(1):126-32. doi: 10.3748/wjg.v20.i1.126. Review.
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NKT cells as an ideal anti-tumor immunotherapeutic.
Fujii S, Shimizu K, Okamoto Y, Kunii N, Nakayama T, Motohashi S, Taniguchi M.
Front Immunol. 2013 Dec 2;4:409. doi: 10.3389/fimmu.2013.00409. Review.
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Mesenchymal stem cells as a vector for the inflammatory prostate microenvironment.
Brennen WN, Denmeade SR, Isaacs JT.
EndocrRelatCancer. 2013 Aug 23;20(5):R269-90. doi: 10.1530/ERC-13-0151. Print 2013 Oct. Review
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Mesenchymal stem cells as vectors for lung cancer therapy.
Kolluri KK, Laurent GJ, Janes SM.
Respiration. 2013;85(6):443-51. doi: 10.1159/000351284. Epub 2013 May 23. Review.
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Therapeutic potential of stem cells expressing suicide genes that selectively target human breast cancer cells: evidence that they exert tumoricidal effects via tumor tropism (review).
Yi BR, Choi KJ, Kim SU, Choi KC.
Int J Oncol. 2012 Sep;41(3):798-804. doi: 10.3892/ijo.2012.1523. Epub 2012 Jun 20. Review.
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Mesenchymal stem cell-based tumor-targeted gene therapy in gastrointestinal cancer.
Bao Q, Zhao Y, Niess H, Conrad C, Schwarz B, Jauch KW, Huss R, Nelson PJ, Bruns CJ.
Stem Cells Dev. 2012 Sep 1;21(13):2355-63. doi: 10.1089/scd.2012.0060. Epub 2012 Jun 26. Review
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The use of neural stem cells in cancer gene therapy: predicting the path to the clinic.
Ahmed AU, Alexiades NG, Lesniak MS.
CurrOpinMolTher. 2010 Oct;12(5):546-52. Review.
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Toward brain tumor gene therapy using multipotent mesenchymal stromal cell vectors.
Bexell D, Scheding S, Bengzon J.
MolTher. 2010 Jun;18(6):1067-75. doi: 10.1038/mt.2010.58. Epub 2010 Apr 20. Review.
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Stem cells as vectors for antitumour therapy.
Loebinger MR, Janes SM.
Thorax. 2010 Apr;65(4):362-9. doi: 10.1136/thx.2009.128025. Review.
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Crossing the boundaries: stem cells and gene therapy.
Ferguson SD, Ahmed AU, Thaci B, Mercer RW, Lesniak MS.
Discov Med. 2010 Mar;9(46):192-6. Review.
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Directing systemic oncolytic viral delivery to tumors via carrier cells.
Nakashima H, Kaur B, Chiocca EA.
Cytokine Growth Factor Rev. 2010 Apr-Jun;21(2-3):119-26. doi: 10.1016/j.cytogfr.2010.02.004. Epub 2010 Mar 11. Review.
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Overview of gene therapy clinical progress including cancer treatment with gene-modified T cells.
Brenner MK, Okur FV.
Hematology Am SocHematolEduc Program. 2009:675-81. doi: 10.1182/asheducation-2009.1.675. Review.
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Stem cells as delivery vehicles for oncolytic adenoviral virotherapy.
Kranzler J, Tyler MA, Sonabend AM, Ulasov IV, Lesniak MS.
Curr Gene Ther. 2009 Oct;9(5):389-95. Review.
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Murine bone marrow-derived mesenchymal stem cells as vehicles for interleukin-12 gene delivery into Ewing sarcoma tumors.
Duan X, Guan H, Cao Y, Kleinerman ES.
Cancer. 2009 Jan 1;115(1):13-22. doi: 10.1002/cncr.24013. Review.
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Vector-mediated cancer gene therapy: an overview.
Seth P.
CancerBiolTher. 2005 May;4(5):512-7. Epub 2005 May 5. Review.
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Adenovirus as a gene therapy vector for hematopoietic cells.
Marini FC 3rd, Yu Q, Wickham T, Kovesdi I, Andreeff M.
Cancer Gene Ther. 2000 Jun;7(6):816-25. Review.
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Potential use of T cell receptor genes to modify hematopoietic stem cells for the gene therapy of cancer.
Clay TM, Custer MC, Spiess PJ, Nishimura MI.
PatholOncol Res. 1999;5(1):3-15. Review.
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Current status of gene transfer into haemopoietic progenitor cells: application to Langerhans cell histiocytosis.
Brenner M.
Br J Cancer Suppl. 1994 Sep;23:S56-7. Review.
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Last modified: Aug 08, 2014
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