Faculty

Dr. Kinsey was trained in biological imaging techniques at the Dept. of Biological Structure,   Univ. of Washington School of Medicine, and leads an NIH funded research program that  combines subcellular imaging and biochemical approaches to study the biochemistry of egg activation at fertilization. His past research has made use of conventional microscopy, confocal microcopy, live cell calcium imaging, and electron microscopy. He has made extensive use of image quantitation techniques as well as live cell microinjection.  Major contributions include demonstration of the role of several protein tyrosine kinases in calcium signaling during egg activation as well as in pronuclear congression.   As director, he was responsible for obtaining federal funding to purchase the Image core’s confocal live cell imaging equipment.  He also provides assistance and training to Center faculty and staff to enable them to perform microscopy and micromanipulation using equipment with which they are not familiar.      

Sharma, D., & Kinsey, W.H. (2006) Fertilization triggers localized activation of Src-family protein kinases in the zebrafish egg. Devel. Biol.  295: 604-614.

Meng, L., Luo, JP, Li, C., & W. H. Kinsey (2006) Role of SH2 domain-mediated PTK signaling in mouse zygotic development. Reproduction, 132: 413-421.

McGinnis, L.K., Albertini, D.F. and William H. Kinsey (2007) Localized Activation of Src-Family Protein Kinases in the Mouse Egg. Devel. Biol. 306: 241-254.

Sharma, D., and W.H. Kinsey (2008) Regionalized Calcium Signaling in Zebrafish Fertilization.  Int. J. Devel.