NAME
William H. Kinsey, Ph.D.

POSITION TITLE
Associate Professor

EDUCATION/TRAINING

Univ. of Florida, Gainesville

B.S.

1973

Zoology

Univ. of Washington, Seattle

Ph.D

1977

Cell Biol

Johns Hopkins Univ. Baltimore

Postdoc

1979

Biochem

Professional Experience

1973-1977

Graduate student, Dept. of Biological Structure, Univ. of Washington School of Medicine, Seattle.

1977-1979

Postdoctoral Fellow with Dr. W.J. Lennarz, Dept. of Physiological
Chemistry, Johns Hopkins Univ. School of Medicine

1979-1985

Assistant Professor, Dept. of Anatomy & Cell Biology, Univ.of Miami
School of Medicine, Miami, Florida.

1985-1991

Associate Professor, Univ. of Miami School of Medicine

1997 -present

Professor, Univ. of Kansas Medical Center

1968-1970

Arts & Sciences Honors Program

1977-1979

Rockefeller Foundation Postdoctoral Fellowship in Reproductive Biology

1990 - present

NSF Developmental Mechanisms Review Panel

PUBLICATIONS: (1976-present)

Kinsey, W.H., J.A. Rubin and W.J. Lennarz,(1980) Studies on the specificity of sperm binding in echinoid fertilization. Devel. Biol. 74: 245-250.

Kinsey, W.H., G.L. Decker and W.J. Lennarz, Isolation and partial characterization of the plasma membrane of the sea urchin egg. J. Cell Biol. 87: 248-254, 1980.

Wolf, D.E., W.H. Kinsey, W. Lennarz and M. Edidin, Changes in the organization of the sea urchin egg plasma membrane fertilization: Indications from the lateral diffusion rates of lipid soluble fluorescent dyes. Devel.Biol. 81: 133-138.

Kinsey, W.H. and W.J. Lennarz,(1981) Isolation of a glycopeptide that inhibits sperm binding. J. Cell Biol.91: 325-331.

Decker, S.J. and W.H. Kinsey, (1983) Characterization of cortical secretory vesicles from the sea urchin egg. Devel. Biol. 96:37-45

Ribot, H., S.J. Decker, & W. H. Kinsey,(1983) Preparation of plasma membranes from fertilized sea urchin eggs. Devel. Biol. 97: 494-499.

Ribot, H.D., E. Eisenman, and W.H. Kinsey,(1984) Fertilization results in increased tyrosine phosphorylation of egg proteins J. Biol.Chem. 259: 5333-5338.

Kinsey, W.H.,(1984) Regulation of tyrosine specific kinase activity at fertilization. Devel. Biol. 105: 137-143.

Kamel, C.L., J. Bailey, L. Schoenbaum, and W. Kinsey,(1985) Phosphatidylinositol metabolism during fertilization in the sea urchin egg. Lipids, 20: 350-356, 1985.

Kamel, C.L., P.A. Veno, and W.H. Kinsey, (1986) Quantitation of a SRC-like tyrosine protein kinase during fertilization of the sea urchin egg. Biochem. Biophys. Res. Comm. 138: 349-355.

Kinsey, W.H. (1986) Purification & Properties of the egg Plasma Membrane, in Methods in Cell Biology: Echinoderm Gametes & Embryos, Vol. 27: Ed. T.E. Schroeder Academic Press, New York, pp.139-152.

Veno, P.A., N.R. Barton, W. Jiang, and W.H. Kinsey, (1987) Role of Tyrosine Kinases in Embryonic Development. In: Advances in Gene Technology: The Mol Biology of Development, Miami Winter Symposium, Vol. 7: 112-113.

Peaucellier, G., Veno, P.A., and W.H. Kinsey, (1988) Protein tyrosine phosphorylation in response to fertilization. J. Biol. Chem. 263: 13806-13811.

Jiang, W.P., G. Peaucellier, and W. H. Kinsey, (1989) Affinity purification of embryo proteins phosphorylated on tyrosine in vitro.Devel. Growth & Differ.31:573-580

Burgess, D.R., W. Jiang, S. Mamajiwalla, & W. Kinsey,(1989) Intestinal crypt stem cells possess high levels of cytoskeletal associated phosphotyrosine-containing proteins and tyrosine kinase activity relative to differentiated enterocytes. J. Cell Biol. 109: 2139-2144.

Jiang, W., R.A. Gottlieb, W.J. Lennarz, & W.H. Kinsey,(1990) Phorbol ester treatment stimulates tyrosine phosphorylation of a sea urchin egg cortex protein. J. Cell Biol. 110: 1049-1053, 1990.

Peaucellier, G., A.C. Anderson, & W.H. Kinsey, (1990) Protein tyrosine phosphorylation during meiotic divisions of starfish oocytes. Devel. Biol. 138: 391-399.

Veno, P.A., M. Strumski, & W.H. Kinsey, (1990) Purification & Characterization of Echinonectin, a carbohydrate binding protein from sea urchin eggs. Devel. Grow. & Diff.32: 315-319.

Peaucellier, G., A.C. Anderson, W.H. Kinsey, & M. Doree, (1990) Tyrosine phosphorylation of MPF and membrane proteins during maturation of starfish oocytes. In Mechanisms of Fertilization, Plants to Human. Springer Verlag.

Leonardi, C.L., Zhu, W.Y., W.H. Kinsey, & N.S. Penneys, (1991) Seborrheic keratoses from the genital region may contain human papillomavirus DNA. Arch. Derm. 127: 1203-1206.

Jiang, W., P.A. Veno, G. Peaucellier, & W.H. Kinsey, (1991) PH regulation of an egg cortex tyrosine kinase. Devel. Biology 146:81-88.

Leonardi, C.L., W.Y. Zhu, W.H. Kinsey & N.S. Penneys: (1991) Trichilemmonas are not associated with human papillomavirus DNA. J. Cut. Path. 18 (3): 193-197.

Leonardi, C.L. , Zhu, W., Kinsey, W., and Penneys, N.S. (1991) Epidermolytic acanthoma does not contain human papillomavirus DNA. J. Cutan. Pathol. 18: 103-105.

Zhu, W.Y., Leonardi, C.L., Kinsey, W., and Penneys, N.S. (1991) Irritated seborrheic keratoses and benign varucous acanthomas do not contain papillomavirus DNA. J. Cutan. Path. 18: 449-452.

Peaucellier, G., K.L. Shartzer, W. Jiang, K. Maggio, & W.H.Kinsey (1993) Anti-peptide antibody identifies a 57KDa protein tyrosine kinase in the sea urchin egg cortex. Devel. Growth & Diff. 35: 199-208.

Moore, K.L. and W.H. Kinsey (1994) Identification of an Abl-Related protein tyrosine kinase in the cortex of the sea urchin egg: Possible role at fertilization. Devel. Biol. 164: 444 - 455.

Moore, K. L. and W. H. Kinsey (1995) Effects of protein tyrosine kinase inhibitors on egg activation and fertilization -dependent protein tyrosine kinase activity. Devel. Biol. 168: 1-10.

Kinsey, W.H. (1995) Differential phosphorylation of a 57-KDa Protein tyrosine kinase during egg activation. Biochem. Biophys. Res. Comm. 208: 204-209.

Kinsey, W.H. (1995) Protein Tyrosine Kinase Activity during egg activation is important for morphogenesis at gastrulation in The sea urchin embryo. Devel. Biol. 172, 704- 707.

Kinsey, W.H. (1996) Biphasic activation of Fyn kinase activity upon fertilization of the sea urchin egg. Dev-Biol. 174: 281 -287.

Walker, G., Burgess, D., and W.H. Kinsey. (1996) Fertilization promotes selective association of the ABL kinase with the egg cytoskeleton. Eur. J. Cell Biol. 70: 165-171.

Kinsey, W.H. (1997) Tyrosine kinase signaling at fertilization. Biochem. Biophys. Res. Comm. 240, 519-522.

Livingston, B.T., VanWinkle, C.E., & W.H. Kinsey (1998) A fertilization activated protein tyrosine kinase is required to complete gastrulation, but not for initial specification of endoderm and mesoderm in sea urchin embryos. Devel. Biol. 193, 90-99.

Talmor, A., W.H. Kinsey, & R. Shalgi (1998) Expression and immunolocalization of p59fyn tyrosine kinase in rat eggs. Devel. Biol. 194, 38-46.

Shen, S.S. Kinsey, W.H. and Lee, S.J. (1999) Protein tyrosine kinase-dependent release of intracellular calcium in the sea urchin egg. Devel. Grth. & Diff. 41: 345-355.

Starzyk KA, Pijnenborg R & Salafia CM (1999) Decidual and vascular pathophysiology in pregnancy compromise. Seminars in Reproductive Endocrinology 17 (1), 63-72

Rongish, B.J., Wu, W.J., & Kinsey, W.H. (1999) Fertilization-induced activation of phospholipase C gamma in the sea urchin egg. Devel. Biol. 215: 147-154.

Glynn, M., Sanford, T., Hoover, L., Kinsey, W., Dobbs, L., Bruegger, D., (1999) Characterization of HPV in airway papillomas by histologic and biochemical analysis. Annals of otology, Rhinology, & Laryngology 108: 1073-1077.

Rongish, B.J. & Kinsey, W.H. (2000) Transient Nuclear localization of c-Fyn during development of the zebrafish embryo. Anat. Rec. 269: 115-123.

Kinsey, W.H. & Shen, S.S. (2000) Role of Fyn kinase in calcium release during fertilization of the sea urchin egg. Devel. Biol. 225: 253-264.

Wu, W., & W.H.Kinsey (2000) Fertilization triggers activation of Fyn kinase in the zebrafish egg. Int. J. Developmental Biol. 44: 837-841.

Tash, J.S., S. Kim, M. Schuber, D. Seibt, & W.H. Kinsey (2001) Fertilization of Sea Urchin Eggs and Sperm Motility are Negatively Impacted under Low Hypergravitational Forces Significant to Space Flight. Biol. Reprod. 65: 1224-1231.