NAME
Paul F. Terranova, Ph.D.

POSITION TITLE
Director and Professor

EDUCATION/TRAINING

McNeese State Univ., Lake Charles, LA

BS

1969

Biology

McNeese State Univ., Lake Charles, LA

MS

1971

Biology

Louisiana State University, Baton Rouge, LA

PhD

1975

Zool/Physiol

Univ. Kansas Medical Center, Kansas City, KS

PostDoc

1977

Reprod.Biol.

Professional Experience

1977-81

Assistant Prof., Dept. of Physiology, Univ. of Kansas Med Ctr., Kansas City

1981-85

Associate Prof., Dept. of Physiology, Univ. of Kansas Medical Center

1985-present

Professor, Department of Physiology and Obstetrics & Gynecology, Univ. of Kansas Medical Center

1995-present

Director, Center for Reproductive Sciences, Univ. of Kansas Medical Center

1982-1987

Research Career Development Award, NICHD

1982-1986

Biology of Reproduction, editorial board member

1989-1993

Endocrinology, editorial board member

1995-present

Endocrine, editorial board member

1999-present

Journal of Pharmacology and Experimental Therapeutics, editorial board member

1987-1990

Physiological Processes Review Panel, NSF

1989-1993

Reproductive Biology Study Section, NIH

1998-present

Alcohol and Toxicology 4 Study Section, NIH

1987-1990

Society for the Study of Reproduction, Board of Directors

1992-1995

Society for the Study of Reproduction, Secretary

1999-present

Environmental Protection Agency, FIFRA Scientific Advisory Panel

Research Projects Ongoing or Completed During the Last 3 Years:

Ovarian Tumor Necrosis Factor, PI, PF Terranova, NIH 2 R01 CA 50616-10 (1/18/00-12/31/04). This grant studies the molecular mechanisms by which TNF inhibits aromatase in ovarian granulosa cells

Src Tyrosine Kinase and Ovarian Function, PI, PF Terranova, NIH U54 HD 33994-06 (4/1/01-3/31/06). This grant is project 2 of the Center for Reproductive Sciences Grant and the role of Src tyrosine kinase in ovarian function is being assessed.

Center for Reproductive Sciences, PI, PF Terranova, NIH U54 HD 33994-06 (4/1/01-3/31/06). This is a Center grant the contains four research projects, two laboratory cores and an administrative core. This is one of 13 Centers in the US that is part of a cooperative network in reproduction research.

Models Assessing Direct Effects of Dioxins on the Ovary, PI, PF Terranova, EPA 10/1/99-09/30/01. This grant studies mechanisms by which dioxin interrupt follicular development and ovulation.

Testing Novel Compounds that Block Follicular Rupture, PI, PF Terranova, 4/1/00-3/31/03. This grant supports a junior investigator (Brian Petroff, D.V.M., Ph.D.) that I mentor. This project tests novel 'dioxin-like' compounds for their effectiveness to block follicular development.

Src Tyrosine Kinase and Ovarian Cancer, PI, KF Roby, NIH 1 P20 RR 15563-01 (9/30/00-8/31/02). This grant studies the role of Src in epithelial ovarian cancer and uses novel gene therapies in combination with chemotherapies to kill the cancer cells.

Roby, K.F., Laham, N., Terranova, P.F. and Hunt, J.S. Expression and localization of messenger RNA for tumor necrosis factor receptor (TNF-R) I and TNF-RII in pregnant mouse uterus and placenta. Endocrine 3:557-562, 1995.

Terranova, P.F., Hunter, V.J., Roby, K.F. and Hunt, J.S. Tumor necrosis factor-? in the female reproductive tract (a review). Proc. Soc. Exp. Biol. Med. 209:325-342, 1995.

Sancho-Tello, M., Marcinkiewicz, J.L., Justice, W.M., Kimler, B.F., Terranova, P.F., and Hunter, V.J. Reduction of tumor necrosis factor-? bioactivity by a human ovarian epithelial cancer cell line in vitro. Am. J. Obstet. Gynec. 173:1470-1477,1995.

Taylor, CC and Terranova, PF. Lipopolysaccharide inhibits rat ovarian thecal-interstitial cell steroid secretion in vitro. Endocrinology 136:5527-5532, 1995.

Taylor, C.C. and Terranova, P.F. Lipopolysaccharide inhibits LH-stimulated rat ovarian granulosa cell estradol, but not progesterone secretion in vitro. Biol. Reprod. 54:1390-1396, 1996.

Rice, V.M., Williams, V.R., Limback, S.D. and Terranova, P.F. Tumor Necrosis Factor-Alpha Inhibits Follicle Stimulating Hormone-Induced Granulosa Cell Estradiol Secretion in the Human: Dependence on Stage of Follicular Development. Human Reproduction 11: 1256-1261, 1996.

Taylor, C.C. and Terranova, P.F. Src tyrosine kinase activity is related to luteinizing hormone responsiveness: genetic manipulations using mouse MA10 Leydig cells. Endocrinology 137: 5735-5738, 1996.

Terranova, P.F and Montgomery Rice, V. Cytokine Involvement in Ovarian Processes (a review), Am J Reprod Immunol 37: 50-63, 1997.

Taylor, C.C., Limback, D. and Terranova, P.F. Src tyrosine kinase activity in rat thecal-interstitial cells and mouse TM3 Leydig cells is positively associated with cAMP-specific phosphodiesterase activity, Mol Cell Endocrinology 126:91-100, 1997.

Rice, V.M., Limback, D.L., Roby, K.F., and Terranova, P.F. Differential responses of granulosa cells from small and large follicles to follicle stimulating hormone (FSH) during the menstrual cycle and acyclicity: effects of tumor necrosis factor alpha. Human Reprod 13: 1285-1291, 1998.

Rice, V.M., Limback, D.L., Roby, K.F., and Terranova, P.F. Changes in circulating and ovarian concentrations of bioactive tumor necrosis factor-? in the equine chorionic gonadotropin treated immature rat. J Reprod Fertil, 113: 337-341, 1998.

Zhao, Y. Burbach, J.A., Roby, K.F., Terranova, P.F., and Brannian, J.D. Macrophages are the major source of tumor necrosis factor alpha in the porcine corpus luteum. Biol Reprod, 59: 1385-1391, 1998.

Rice, V.M., Limback, D.L., Roby, K.F., and Terranova, P.F. Tumor necrosis factor alpha inhibition of follicle stimulating hormone-induced granulosa cell estradiol secretion in the human does not involve reduction of cAMP secretion but inhibition at post cAMP site(s). Endocrine 10:19-23, 1999.

Bagavant, H, Adams, S., Terranova, P., Chang, A., Kraemer, F.W., Lou, Y., Kasai, K., Luo, A.M., Tung, K.S.K. Autoimmune ovarian inflammation triggered by pro-inflammatory (Th1) T cells is compatible with normal ovarian function, Biol Reprod 61: 635-642, 1999.

Gao, X., Son, D.S., Terranova, P.F., Rozman, K.K. Toxic equivalency (TEQ) of polychlorinated dibenzo-p-dioxins (PCDDs) in an ovulation model: validation of the TEQ concept for endocrine disruption, Toxicol Appl Pharmacol 157: 107-116, 1999.

Son, D.S., Ushinohama, K, Gao, X, Taylor, C.C., Roby, K.F., Rozman, K.K. Terranova, P.F. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) blocks ovulation by a direct action on the ovary without alteration of ovarian steroidogenesis: lack of a direct effect on ovarian granulosa and thecal-interstitial cell steroidogenesis in vitro. Reprod Toxicol 13:521-530, 1999.

Roby, K.F., Son, D.S., Terranova, P.F. Alterations of events related to ovarian function in tumor necrosis factor receptor type 1 knockout mice, Biol Reprod, 61:1616-1621, 1999.

Gao, X, Terranova, P.F., and Rozman K.K. Effects of polychlorinated dibenzofurans (PCDFs), biphenyls (PCBs) and their mixture with dibenzo-p-dioxins (PCDDs) on ovulation in the gonadotropin primed immature rat: support for the toxic equivalency (TEQ) concept, Toxicol Appl Pharmacol 163:115-124, 2000.

Roby, K.F., Taylor, C.C., Cheng, Y., Pace, J.L., Tawfik, O., Persons, D.L., Smith, P.G., and Terranova, P. F. Development of a syngeneic mouse model for events related to ovarian cancer, Carcinogenesis 21: 585-591, 2000.

Petroff, B.K., Gao, X, Rozman, K.K. Terranova, P.F. Interaction of estradiol and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in an ovulation model: Evidence for systemic potentiation and local ovarian effects, Reprod Toxicol 14: 247-255, 2000.

Gao, X., Petroff, B.K., Rozman, K.K. and Terranova, P.F. Gonadotropin releasing hormone (GnRH) partially reverses the inhibitory effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on ovulation in the immature gonadotropin-treated rat, Toxicology 147: 15-22, 2000.

Petroff, B.K., Roby, K.F., Gao, X, Son, D-S, Williams, S., Johnson, D., Rozman, K.K. Terranova, P.F. A review of mechanisms controlling ovulation with implications for the anovulatory effects of polychlorinated dibenzo-p-dioxins (PCDDs) in rodents, Toxicology 158: 91-107, 2001.

Gao, X., Mizuyachi, K., Terranova, P.F., Rozman, K.K. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) decreases responsiveness of the hypothalamus to estradiol as a feedback inducer of preovulatory gonadotropin secretion in the immature gonadotropin-primed rat, Toxicology and Applied Pharmacology 170: 181-190, 2001. (COVER ISSUE)

Ushinohama, K., Son, D-S, Roby, K.F., Rozman, K.K. and Terranova, P.F. Impaired ovulation by 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) in immature rats treated with equine chorionic gonadotropin, Reproductive Toxicology 15:275-280, 2001

Petroff B.K., Gao X., Rozman K.K., and Terranova P.F. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on weight gain and hepatic ethoxyresorufin-o-deethylase (EROD) induction vary with ovarian hormonal status in the immature gonadotropin-primed rat model. Reprod. Toxicol. 15:269-274, 2001

Montgomery Rice,V. Chaudhery, A., Oluola, O., Limback, S.D., Roby, K.F., and Terranova, P.F. Herbimycin, a tyrosine kinase inhibitor with Src selectivity, reduces human granulosal cell progesterone and estradiol secretion. Endocrine 15: 271-276, 2001.

Ohshima, K., Arai, K.Y., Kishi, H., Itoh, M., Watanabe, G., Terranova, P.F., Arai, K., Uehara, K., Groome, N.P., Taya, K. Potential role of activin A in follicular development during the second half of pregnancy in the golden hamster: utero-placental source of activin A. Journal of Endocrinology, in press.

Petroff, B.K., Gao, X., Ohshima, K-I, Shi F.X., Son, D-S, Roby, K.F., Rozman, K.K., Watanabe, G., Taya, K., and Terranova, P.F. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on serum inhibin concentrations and inhibin immunostaining during follicular development in female Sprague-Dawley rats. Reprod. Toxicol., in press.