NAME
Peter G. Smith

POSITION TITLE
Professor

EDUCATION/TRAINING

University of New Hampshire, Durham, N.H.

B.A.

1970-1973

Zoology/ Chemistry

Duke University, Durham, N.C.

Ph.D.

1973-1978

Physiology/ Pharmacology

Duke University, Durham, N.C.

Post-Doc.

1978-1982

Neuroscience

Positions

1982-1987

Assistant Medical Research Professor, Department of Pharmacology,
Duke University Medical Center

1987-1993

Associate Professor, Department of Physiology, University of Kansas Medical Center

1993-present

Professor, Department of Molecular and Integrative Physiology and
Professor, Department of Physical Therapy Education,
University of Kansas Medical Center

1993-present

Scientific Director, Biobehavioral Imaging and Graphics Core, R.L. Smith Mental Retardation Research Center, University of Kansas Medical Center

1978-1980

Pharmacology/Morphology Fellow of the Pharmaceutical Manufacturers Association Foundation

1983-1988

Established Investigator of the American Heart Association

1987-1993

Associate Professor, Department of Physiology, University of Kansas Medical Center

1993-1995

Chair, Neurology B2 Study Section (Regular member, 1991-1995)

1996

Recipient, Investigator Research Award, School of Medicine

1997

Recipient of a W. T. Kemper Foundation Fellowship for Teaching Excellence

Selected peer-reviewed publications (in chronological order).

Smith, P.G., Krizsan-Agbas, D., Warn, J.D., Steinle, J.J., and Hasan, W. (2001) Modulation of parasympathetic neuron phenotype and function by sympathetic innervation. Autonomic Neuroscience, in press.

Smith, P.G. and Liu, M. (2001) Impaired Cutaneous Wound Healing after Sensory Denervation in Developing Rats: Effects on Cell Proliferation and Apoptosis. Cell and Tissue Research, in press.

Zoubina, E., Mize, A.L., Alper R.F., and Smith, P.G. (2001) Acute and chronic estrogen supplementation decreases uterine sympathetic innervation in ovariectomized adult virgin rats. Histology and Histopathology, 16: 989-996.

Zoubina, E. V. and Smith, P.G. (2001) Uterine sympathetic hyperinnervation in the estrogen receptor a knock-out mouse. Neuroscience, 103: 237-244.

Hasan, W. and Smith, P.G. (2000) Nerve Growth Factor expression in parasympathetic neurons: regulation by sympathetic innervation. European Journal of Neuroscience, 12: 4391-4397.

Steinle, J.J. and Smith, P.G. (2000) Presynaptic muscarinic facilitation of parasympathetic neurotransmission following sympathectomy in the rat choroid. Journal of Pharmacology and Experimental Therapeutics, 294: 627-632.

Zoubina, E.V. and Smith, P.G. (2000) Axonal degeneration and regeneration in rat uterus during the estrous cycle. Autonomic Neuroscience, 84: 176-185
Steinle,J.J., Krizsan-Agbas,D., and Smith, P.G. (2000) Regional regulation of choroidal blood flow by autonomic innervation in the rat. American Journal of Physiology, 279: R202-R209.

Hasan, W., Zhang, R. Liu, M., Warn, J.D., and Smith, P.G. (2000) Coordinate expression of NGF mRNA and a-smooth muscle actin in cutaneous wound tissue of developing and adult rats. Cell and Tissue Research, 300: 97-109.

Roby, K.F., Taylor, C.C., Cheng, Y., Pace, J., Tawfik, O., Persons, D.L., Smith, P.G. and Terranova, P.F. (2000) Development of a syngeneic mouse model for events related to ovarian cancer. Carcinogenesis, 21: 585-591.

Liu, M., Warn, J.D., Fan, Q. and Smith, P.G. (1999) Relationships between nerves and myofibroblasts and during cutaneous wound healing in the developing rat. Cell and Tissue Research, 297: 423-433.

Smith, P.G., Fan, Q. and Zhang, R. (1999) Divergence of smooth muscle target and sympathetic pathway cell phenotypes in the orbit of the developing rat. Journal of Comparative Neurology 408: 352-364.

Krizsan-Agbas, D., Zhang, R., Marzban, F. and Smith, P.G. (1998) Presynaptic adrenergic facilitation of parasympathetic neurotransmission in sympathectomized rat smooth muscle. Journal of Physiology (London) 512: 841-849.

Zoubina, E., Fan, Q. and Smith, P.G. (1998) Variations in uterine innervation during the estrous cycle in the rat. Journal of Comparative Neurology 397: 561-571.

Smith, P.G., Fan, Q., Zhang, R. and Warn, J.W. (1998) Cellular terrain surrounding sympathetic nerve pathways in the rat orbit: comparisons of orbital connective tissue and smooth muscle cell phenotypes. Journal of Comparative Neurology 400: 529-543.

Smith, P.G., and Marzban, F. (1998) Parasympathetic varicosity proliferation and synaptogenesis in rat eyelid smooth muscle after sympathectomy. Brain Research 786: 171-180.

Hiebert, J.M., Fan, Q. and Smith, P.G. (1997) Decreased receptivity of pathway connective tissue to sympathetic nerve ingrowth in the developing rat. Developmental Brain Research 100: 35-42.

Warn,J.D., Fan, Q. and Smith, P.G. (1997) Decreased neuronal nitric oxide synthase-immunoreactivity and NADPH-diaphorase activity in rat pterygopalatine ganglion parasympathetic neurons following long-term sympathectomy. Neuroscience Letters 232: 25-28

Clancy, R.L. Moue, Y. Erwig, L.P, Smith, P.G. and Gonzalez, N.C. (1997) Role of badrenergic and cholinergic systems in hypoxic exercise performance in rats. Respiratory Physiology, 107:75-84

Beauregard, C.L. and Smith, P.G. (1996) Parasympathetic excitation of sympathetic neurotransmission following cholinesterase inhibition. Br. J. Pharmacology, 117: 51-54.

Smith, P.G. and Fan, Q. (1996) Trajectory of sympathetic innervation to rat orbital targets: role of connective tissue pathways. Journal of Comparative Neurology, 365: 69-78

Hiebert, J. and Smith, P.G. (1995) Reinnervation of denervated iris by transplanted sympathetic ganglia: effect of postnatal age. International Journal of Developmental Neuroscience, 13: 627-634.

Moue,Y., Smith, P.G., Clancy,R.L. and Gonzalez,N.C. (1995) Role of vasoconstrictors in the systemic hypertension of rats acclimitized to hypoxia, Journal of Applied Physiology: 39 1657-1667.

Beauregard, C. and Smith, P.G. (1994) Parasympathetic innervation of rat peri-orbital smooth muscle: prejunctional cholinergic inhibition of sympathetic neurotransmission without direct postjunctional actions. J. Pharmacol. Exp. Ther., 268: 1284-1288.

Simons,E.J. and Smith, P.G. (1994) Sensory and autonomic innervation of the rat eyelid: Origins and peptide phenotypes. Journal of Chemical Neuroanatomy 7: 35-47.

Hiebert,J. and Smith, P.G. (1994) Autonomic and sensory reinnervation of smooth muscle transplanted to the anterior chamber of the eye: effect of target postnatal age. Experimental Neurology, 127:137-144.

Smith, P.G. and Beauregard, C.L. (1993) Conversion of parasympathetic nerve function from prejunctional inhibition to postjunctional excitation following sympathectomy of rat periorbital smooth muscle. Brain Research, 629: 319-322.

Sharp, C.E., and Smith, P.G. (1992) Developmental regulation of parasympathetic nerve density by sympathetic innervation in the tarsal smooth muscle of the rat. Neuroscience 49: 229-236.

Fike, E.A.IV, Simons, E., Boswell, C., and Smith, P.G. (1992) Sensory nerves impair sympathetic reinnervation and recovery of smooth muscle function. Experimental Neurology 118: 85-94.

Wanger, M. and Smith, P.G. (1992) Neuropeptide Y inhibits sympathetic neurotransmission in ipsilaterally innervated but not contralaterally reinnervated superior tarsal smooth muscle of the rat. Regulatory Peptides 42:145-152.

Fan, Q. and Smith, P.G. (1993) Decreased vasoactive intestinal polypeptide-immunoreactivity of parasympathetic neurons and target innervation following long-term sympathectomy. Regulatory Peptides, 48:337-343

Smith, P.G., Reddy, H., and Venkataraman, P. (1990) Sympathetic sprouting into neonatally denervated contralateral target: superior cervical ganglion neuronal numbers and sizes. Developmental Brain Research 53:208-214.

Smith, P.G., Venkataraman, P., and Reddy, H. (1990) Smooth muscle growth in the mature rat: role of sympathetic innervation. Journal of the Autonomic Nervous System 31:13-20.

Mills, E., Bruckert, J.W., and Smith, P.G. (1990) Influence of postnatal maternal stress on blood pressure and heart rate of juvenile and adult rat offspring. Developmental Psychobiology 23:839-847.

Smith, P.G., and Reddy, N.H. (1990) Reorganization of cranial sympathetic pathways following neonatal ganglionectomy in the rat. Journal of Comparative Neurology 301:490-500.

Smith, P.G., Hoffman, T.L. and Reddy, H. (1991) Sprouting of aberrant neuropeptide Y-immunoreactive sympathetic nerves into neonatally denervated smooth muscle. Regulatory Peptides 35:103-113.

Research Support

ONGOING:

1 RO1 NS39570-02 Smith (PI)
NIH/NINDS

12/1/99-11/30/03
$152,748

20%

Sympathetic Nerve Remodeling in the Adult Uterus
The goals of this project are to investigate molecular mechanisms of physiological nerve plasticity in the myometrium of the rodent uterus.

1 RO1 HD38670-02 Smith (PI)
NIH/NICHD

4/1/00-3/31/05
$137,426

20%

Neurotrophins, Hormones and Postparous Incontinence
This project's goals are to understand the interactions of pregnancy-associated hormones and neurotrophic molecules in modulating sympathetic nerve regeneration.

KUMC Research Institute Lied Endowed Basic Science Research Grant Long (PI)

5/1/01-4/31/02
$25,000

5%

Effect of Topical Morphine Analgesia on Cutaneous Wound Healing
This study examines the effects of topical morphine on the ability of sensory nerves to promote cutaneous wound healing.

2 P30 HD 02528 Warren (PI)
NIH/NICHD

8/1/01-7/31/06
$233,334

10%

Kansas Mental Retardation Research Center (Core D, Biobehavioral Imaging and Graphics Core)
The goal of the Kansas MRRC is to provide core support to investigators conducting projects relevant to mental retardation and developmental disabilities. Smith's role as Scientific Director of the Biobehavioral Imaging and Graphics Core is oversee core activities dedicated to image analysis, image output and graphics and illustration.

3 RO1 NS39570-01s1 Smith (PI)
NIH/NINDS

10/1/00-9/30/01
$50,000

-

DNA Microarray Analysis Administrative Supplement
This supplement provides support to conduct cDNA microarray studies to identify candidate molecules mediating neural plasticity.

RO1 HD33025 Smith (PI)
NIH/NICHD

9/1/94-8/31/00
$123,423

20%

Conversion of Parasympathetic Function after Injury
The goal of this study was to examine mechanisms responsible for altered phenotype and function of parasympathetic nerves when co-projecting sympathetic nerves are damaged.

RO1 NS23502 Smith (PI)
NIH/NINDS

12/1/95-11/30/2000
$153,878

20%

Sympathetic neuroplasticity
The goals of this project were to elucidate mechanisms of enhanced sympathetic neuroplasticity and pathway formation in the developing rat.