NAME
Michael J. Soares

POSITION TITLE
Professor

EDUCATION/TRAINING

California State University, Chico, CA

B.A.

1972-76

Psychology

University of Hawaii, Honolulu, HI

Ph.D.

1977-81

Reprod. Biology

University of California-Santa Cruz, CA

Post-doc

1981-83

Endocrinology

Baylor College of Medicine-Houston, TX

Post-doc

1983-84

Cell Biology

Professional Experience

1984-89

Assistant Professor, Department of Physiology, University of Kansas Medical Center, Kansas City, KS

1989-93

Associate Professor, Department of Physiology, University of Kansas Medical Center, Kansas City, KS

1993 to present

Professor, Department of Physiology, University of Kansas Medical Center, Kansas City, KS

EDITORIAL BOARDS, STUDY SECTIONS, HONORS AND AWARDS:

Biology of Reproduction (1990 to1995); Trophoblast Research (1996 to present); Endocrinology (1998 to 2002); Journal of Endocrinology (2000 to present); National Institutes of Health: Human Embryology and Development II Study Section (1993 to 1996); Castellucci Award Lecture for achievement in Placental Research (1995); Senior Editor, Journal of Endocrinology 2000 to present)

Research Projects Ongoing or Completed During the Last 3 Years:

"Pregnancy-specific Modulation of Natural Killer Cells" [ONGOING]
Principal Investigator: Michael J. Soares, Ph.D.
Agency: NICHD; Type: RO1 (HD37123, years 1-3), Period: August 13, 1999 to August 1, 2002.

The major goal of this project is to investigate the actions of a placental protein, PLP-A, on the function of uterine natural killer cells.

"Novel Cytokine-Natural Killer Cell Signaling" [ONGOING]
Principal Investigator: Michael J. Soares, Ph.D.
Agency: NICHD; Type RO3 (HD38430, years 1-2), Period: March 10, 2000 to February 28, 2002

The major goal of this project is to characterize the NK cell signal transduction pathway used by PLP-A.

"Trophoblast Differentiation" [ONGOING]
Principal Investigator: Michael J. Soares, Ph.D.
Agency: NICHD; Type: RO1 (HD20676, year 13-17), Period: December 1, 2001 through November 30, 2006.

The major goal of this project is to investigate the regulation of trophoblast cell differentiation.

"Maternal Adaptations to Pregnancy" [ONGOING]
Principal Investigator: Michael J. Soares, Ph.D.
Agency: NICHD; Type RO1 (HD40413, years 1-5), Period: April 1, 2001 to March 30, 2005.

The major goal of this project is to characterize the biology of decidual proteins related to prolactin.

Original Research Publications: (1997-2001; partial listing from 119 research publications, excluding abstracts)

All peer-reviewed publications: 1997-2001

94. Cohick CB, Xu L, Soares MJ 1997 Heterologous expression and characterization of placental and decidual prolactin-like protein-B. J Endocrinol 152, 291-302

95. Manzella SM, Dharmesh SM, Cohick CB, Soares MJ, Baenziger JU 1997 Developmental regulation of a pregnancy-specific oligosaccharide structure, NeuAca2,6GalNAcß1,4GlcNAc on select members of the rat placental prolactin family. J Biol Chem 272, 4775-4782

96. Rasmussen CA, Orwig KE, Vellucci S, Soares MJ 1997 Dual expression of prolactin-related protein in decidua and trophoblast tissues during pregnancy. Biol Reprod 55, 647-654

97. Orwig KE, Dai G, Rasmussen CA, Soares MJ 1997 Decidual/trophoblast prolactin related protein: characterization of gene structure and cell-specific expression. Endocrinology 138, 2491-2500

98. Shi F, Kenagy J, Avery M, Soares MJ, Audus KL 1997 Permeability and metabolic properties of a trophoblast cell line (HRP-1) derived from normal rat placenta. Exp Cell Res 228, 147-155

99. Kamei T, Hamlin GP, Chapman BM, Burkhardt AL, Bolen JB, Soares MJ 1997 Signaling pathways controlling trophoblast cell differentiation: Src-family protein tyrosine kinases. Biol Reprod 57, 1302-1311

100. Liu F, Soares MJ, Audus KL 1997 Permeability properties of monolayers of the human trophoblast cell line, BeWo. Am J Physiol 273: C1596-C1604

101. Orwig KE, Ishimura R, Müller H, Liu B, Soares MJ 1997 Identification and characterization of a mouse homolog for decidual/trophoblast prolactin-related protein. Endocrinology 139, 5511-5517

102. Müller H, Ishimura R, Orwig KE, Liu B, Soares MJ 1998 Homologues for prolactin-like protein-A and B are present in the mouse. Biol Reprod 58, 45-51

103. Orwig KE, Wolfe MW, Cohick CB, Dai G, Peters TJ, Soares MJ 1998 Trophoblast-specific regulation of endocrine-related genes. Troph Res 11, 65-85.

104. Soares MJ, Dai G, Orwig KE, Peters TJ, Müller HM 1998 The uteroplacental prolactin family and pregnancy. Biol Reprod 58, 273-284

105. Müller H, Orwig KE, Soares MJ 1998 Identification of two new members of the mouse prolactin family. Biochim Biophys Acta 1396, 251-258

106. Müller H, Dai G, Soares MJ 1998 Placental lactogen-I (PL-I) target tissues identified with an alkaline phosphatase-PL-I fusion protein. J Histochem Cytochem 46, 1-7

107. Amura CR, Kamei T, Ito N, Soares MJ, Morrison DC 1998 Differential regulation of lipopolysaccharide (LPS) activation pathways in mouse macrophages by LPS binding proteins. J Immunol 161, 2552-2560

108. Dai G, Chapman BM, Liu B, Wang D, Orwig KE, White RA, Preuett B, Soares MJ 1998 A new mouse member of the prolactin-like protein-C subfamily: structure and expression. Endocrinology 139, 5157-5163

109. Kenagy J, Liu F, Soares MJ, Audus KL 1998 Gestational and smoking effects on peptidase activity in the placenta. Peptides 19, 1659-1666

110. Peters TJ, Albieri A, Bevilaqua E, Chapman BM, Crane L, Hamlin GP, Seiki M, Soares MJ 1999 Differentiation-dependent expression of gelatinase B/MMP-9 in rat trophoblast cells. Cell Tissue Res 295, 287-296.

111. Dai G, Chapman BM, Wang D, White RA, Preuett B, Soares MJ 1999 Prolactin-like protein-A gene structure and chromosomal mapping. Mammalian Genome 10, 78-80
112. Knipp GT, Audus KL, Soares MJ 1999 Nutrient transport across the placenta. Adv Drug Delivery Rev 38, 41-58

113. Müller H, Liu B, Croy BA, Head JR, Hunt JS, Dai G, Soares MJ 1999 Uterine natural killer cells are targets for a trophoblast cell-specific cytokine, prolactin-like protein-A. Endocrinology 140, 2711-2720

114. Orwig KE, Soares MJ 1999 Transcriptional activation of the decidual/trophoblast prolactin-related protein gene. Endocrinology 140, 4032-4039

115. Dai G, Wolfe MW, Soares MJ 1999 Distinct regulatory regions from the prolactin-like protein-C variant promoter direct trophoblast giant cell versus spongiotrophoblast cell-specific expression. Endocrinology 140, 4691-4698

116. Lee Y, Yang S-P, Soares MJ, Voogt JL 2000 Distribution of prolactin releaseing peptide (PrRP) mRNA in the rat brain. Brain Research Bulletin 51, 171-176

117. Sahgal N, Knipp GT, Liu B, Chapman BM, Dai G, Soares MJ 2000 Identification of two new nonclassical members of the rat prolactin family. Journal of Molecular Endocrinology 24, 95-108

118. Peters TJ, Chapman BM, Wolfe MW, Soares MJ 2000 Placental lactogen-I gene activation in differentiating trophoblast cells: extrinsic and intrinsic regulation involving mitogen-activated protein kinase signaling pathways. J Endocrinology 165, 443-456

119. Dai G, Wang D, Liu B, Kasik JW, Müller H, White RA, Hummel GS, Soares MJ 2000 Three novel paralogs of the rodent prolactin gene family. J Endocrinology 166, 63-75

120. Knipp GT, Liu B, Audus KL, Fujii H, Ono T, Soares MJ 2000 Fatty acid transport regulatory proteins in the developing rat placenta and in trophoblast cell culture models. Placenta 21, 367-375

121. Wang, D., Ishimura, R., Walia, D.S., Müller, H., Dai, G., Hunt, J.S., Lee, N.A., Lee, J.J., and Soares, M.J. 2000 Eosinophils are cellular targets of the novel uteroplacental heparin-binding cytokine, decidual/trophoblast prolactin-related protein. J Endocrinology 167, 15-29

122. Bittorf, T., Jaster, R., Soares, M.J., Seiler, J., Brock, J., Friese, K., and Müller, H. (2000) Induction of erythroid proliferation and differentiation by a trophoblast-specific cytokine involves activation of the Jak/STAT pathway. Journal of Molecular Endocrinology 25, 253-262

123. Ain, R., Müller, H., Sahgal, N., Dai, G., and Soares, M.J. (2001) Uteroplacental prolactin family: immunological regulators of viviparity. Neuroimmune Biology 3, in press.

124. Audus, K.L., Soares, M.J., and Hunt, J.S. (2001) The maternal-fetal interface: a source of novel immunological and pharmacological approaches to protect the fetus. Journal of Pharmacology and Experimental Therapeutics, in press

125. Ain, R., Tash, J.S., and Soares, M.J. (2001) A simple method for the in situ detection of eosinophils. Journal of Immunological Methods, in press

Book Chapters and Symposium Proceedings:

8. Soares MJ 1997 Molecular mechanisms of placental development. In: Placental Function and Fetal Nutrition. FC Battaglia (ed), Lippincott-Aven Publishers, Philadelphia, pp. 41-53.

9. Soares, MJ, Dai G, Cohick CB, Müller H, Orwig KE 1998 The rodent placental prolactin family and pregnancy. In: Endocrinology of Pregnancy, F.W. Bazer (ed), Humana Press Inc., New Jersey, pp. 145-176

10. Audus KL, Liu F, Ampasavate C, Soares MJ, Stobaugh JF 1998 Factors regulating peptide passage across the placental barrier. In: Alfred Benzon Symposium 43, Peptide and Protein Delivery, Munksgaard International Publishers Ltd., Copenhagen, pp. 67-74

11. Peters TJ, Chapman BM, Soares MJ 2000 Trophoblast differentiation: an in vitro model for trophoblast giant cell development. In: Developmental Protocols, RS Tuan , CW Lo (eds), Humana Press, Totowa, NJ, pp. 301-311

12. Soares, M.J., Wang, D., Sahgal, N., Müller, H., and Dai, G. (2000) Uteroplacental signals in the establishment of pregnancy: The prolactin family. In: Clone Animals and Placentation, K. Hashizume (ed), Yokendo Publishers, Tokyo, Japan, pp. 122-129

13. Soares MJ and Linzer DIH 2001 Rodent prolactin family and pregnancy. In: Prolactin, N.D. Horseman (ed), Kluwer Academic Publishers, Norwell, MA, pp. 139-167