Tsuneo Suzuki, M.D., Ph.D.

Professor Emeritus

M.D., University of Tokyo, 1957. Ph.D., University of Hokkaido, 1968

email

Selected Publications

Suzuki, T. 1991. Signal transduction mechanisms through Fcg receptors on the mouse macrophage surface. FASEB J.: 5:187-193.

Novotney, M., Chang, Z-L., Uchiyama, H. and Suzuki, T. 1991. Protein kinase C in tumoricidal activation of mouse macrophage cell lines. Biochemistry 30:5597-5604.

Chen, T-Y, Lei, M-G., Suzuki, T and Morrison, D.C. 1992. The macrophage receptor for bacterial lipopolysaccharide. In Macrophages and macrophage activation, eds. S. Gordon and S.W. Russell, Spring Verlag Inc., Heidelberg, p. 169-188.

Muroi, M. and Suzuki, T. 1993. Role of protein kinase A in activation of NF-kB proteins of a mouse macrophage-like cell line, J774. Cellular Signalling 5:289-298.

Muroi, M., Muroi, Y., Yamamoto, K., and Suzuki, T. 1993. Influence of 3' half site sequence of NF-kB motifs on the binding of lipopolysaccharide-activatable macrophage NF-kB proteins. J. Biol. Chem. 268:19534-19539.

Fujihara, M., Muroi, M., Ito, N., Muroi, Y. and Suzuki, T. 1993. Mechanism of lipopolysaccharide-triggered junB activation in a mouse macrophage-like cell line (J774). J. Biol. Chem. 268:14898-14905.

Fujihara, M., N. Connolly, N. Ito and Suzuki, T. 1994. Properties of protein kinase isoforms (bII, e, and z) isoforms in a macrophage cell line (J774) and their roles in LPS-induced nitric oxide production. J. Immunol. 152:1898-1906.

Fujihara, M., Ito, N., Pace,J. L., Watanabe, Y., Russell, S. W., and Suzuki, T. 1994. Role of endogenous interferon- b in lipopolysaccharide-triggered activation of inducible nitric oxide synthase gene in a mouse macrophage cell line, J774. J. Biol. Chem. 269:12773-12778.

Muroi, M., Muroi, Y., and Suzuki, T. 1994. The binding of immobilized IgG2a to Fcg 2a receptor activates NF-kB via reactive oxygen intermediates and TNF-a. J. Biol. Chem. 269:30561-30568.

Muroi, M., Muroi, Y., Ito, N., Rice, N.R., and Suzuki, T. 1995. Effects of protease inhibitors on LPS-medicated activation of a mouse macrophage cell line (J774). J. Endotoxin Res. 2: 337-347.

Sato, K., Fujihara, M., Takahashi, T.,A., Yoo, Y. C., Hata, K., Tonooka, S., Suzuki, T., Sekiguchi, S., and Azuma, I. 1995. Endotoxin antagonism by a synthetic lipid A analogue, DT-5461, with low endotoxicity in human peripheral blood monocytes. Biochem. Biophys. Res. Commun. 216: 367-374.

Murphy, W., Muroi, M., Zhang, X., Suzuki, T., and Russell, S.W.1996. Both basal and enhancer kB elements are required for full induction of themouse inducible nitric oxide synthase gene. J. Endotoxin Res. 3:381-393.

Fujihara, M., Ikebuchi, K., Maekawa, T.L., Wakamoto, S., Ogiso, C, Ito, T.,Takahashi, T.A., Suzuki, T., and Sekiguchi, S. 1998. Lipopolysaccharide-induced desensitation of junB gene expression in a mouse macrophage-like cell line, P388D1. J. Immuol. 161:3659-3665.

Ito, N., Li, Y., Suzuki, T., Stechschulte, D.J., and Dileepan, K.N. 1998. Transient Degradation of NF-kB proteins in macrophages after interaction with mast cell granules. Mediators of Inflammation 7:397-407.

Nagai, E., Ogawa, T., Kielian, T., Ikubo, A., and Suzuki, T.. 1998. Irradiated tumor cells adenovirally engineered to secrete GM-CSF established anti-tumor immunity and eliminate pre-existing tumors in syngeneic mice. Cancer Immunol. Immunother. 47:72-80.

Suzuki, T. 1999. Role of NF-kB in macrophage activation. (review) In Endotoxin in Health and Disease, eds. by D. C. Morrison, H. Brade, S. Opal, and S. Vogel. Marcel Dekker, N.Y., N.Y.. pg. 502-520.

Kielian, T., Nagai, E., Ikubo, A., Rasmussen, C.A., and Suzuki, T. 1999. GM-CSF released by adenovirally-transduced CT26 cells leads to accumulation of dendritic cells at vaccination sites in vivo and local expression of MIP-1a. Cancer Immunol. and Immunother. 48:123-131.

Ikubo, A., Aoki, Y., Nagai, E., and Suzuki, T. 1999. Highly metastatic variant of a mouse colon carcinoma cell line, LM17 and its response to GM-CSF gene therapy. Clinical and Experimental Metastasis 17:849-855.

Fujihara, M., Wakamoto, S., Ito, T., Muroi, M., Suzuki, T., Ikeda, H., and Ikebuchi, K. 2000. Lipopolysaccharide-triggered desensitization of TNF-a mRNA expression involves lack of phosphorylation of Ikappa B alpha in a murine macrophage-like cell line, P388D1. J. Leukoc. Biol. 68:167-276.

Kusumoto, M., Umeda, S., Ikubo, A., Aoki, Y., Tawfik, O., Oben, R., Williamson, S., Jewell, W., and Suzuki, T. 2001. Phase 1 clinical trial of irradiated autologous melanoma cells adenovirally transduced withhuman GM-CSF gene. Cancer Immunol. Immunother. 50:373-381.