Slide 15 Astrocytes
Astrocytes are star-shaped glial cells of the CNS that have long processes. Many of these processes extend to blood vessels where they expand and cover much of the external wall. The expanded endings of the astrocyte processes are known as end-feet. While the blood-brain-barrier is formed by tight junctions between endothelial cells, the end-feet function to induce and maintain the blood-brain barrier. In pathology following stroke the relationship of end-feet to the endothelial cells is altered leading to disruption of the blood-brain barrier and subsequent leakage.

Bar = 30 Microns

Expanded View