• Project Funding
• Milestone Research Funding
IAMI's collaboration with local, regional and national partners contributes to the advancement of drug, diagnostic and medical device technologies to help people and improve patient care.
A key IAMI collaborative partnership is with the Center for Pediatric Genomic Medicine (CPGM) at Children's Mercy Kansas City (CMH), established in 2011, and the Kansas Intellectual and Developmental Disabilities Research Center (KIDDRC) at the University of Kansas. Read more »
Partnership: The CPGM is among the first of its kind with a pediatric focus, providing clinical genomics services and genomic research in rare, inherited diseases in children. The KIDDRC, supported by the National Institute for Child Health and Human Development (NICHD) for nearly 50 years, conducts research aimed at the causes, prevention and treatment of intellectual and related developmental disabilities. Building upon these regional strengths and capabilities in rare disease genomic medicine and intellectual and developmental research, IAMI collaborated with CPGM and KIDDR to develop the Gene-to-Drug-to-Children (GDC) strategy.
Success Story: The GDC strategy allows researchers to characterize the biology of a genomic discovery, identify and validate drug targets, discover new agents, exploit opportunities to repurpose existing drugs and advance promising new treatments to children suffering from rare diseases. With more than 7,500 single gene disorders reported, GDC provides a framework for selecting initial rare disease projects to demonstrate proof of concept based on unmet medical need, patient value and feasibility criteria and characteristics. Frontiers: Heartland Institute for Clinical and Translational Research patient and community engagement lead, Dr. Kim Kimminnau, Kelly Ranallo, co-founder and president of the Turner Syndrome Global Alliance and IAMI director Scott Weir Pharm.D., Ph.D., have brought together Frontiers partners University of Kansas Medical Center, CMH, University of Missouri-Kansas City, the Stowers Institute for Medical Research, the Global Genes Project, the Turner Syndrome Global Alliance and the Kansas City area chapter of the Cystic Fibrosis Foundation to rally the Kansas City region in support of T1 through T4 rare disease translational research.
IAMI has led a partnership between Frontiers and KU Cancer Center to establish the Target Acceleration Group (TAG). Read more »
Partnership: The TAG works directly with investigators from Frontiers, other Clinical and Translational Science Award hubs and National Cancer Institute Cancer Centers to create high potential projects at the chemistry/biology interface and advance these projects to in vivo preclinical proof of principle.
Success Story: TAG builds upon the drug discovery and development infrastructure within KU, created in part through participation in the National Institutes of Health-funded Molecular Libraries and NCI Experimental Therapeutics Programs to assist teams of basic and clinical (disease expert) researchers in drug discovery and development. TAG is comprised of a multi-disciplinary, multi-organizational team of experts that integrates project management, assay development, medicinal chemistry, drug delivery, pharmacokinetics and pharmacodynamics and clinical pharmacology disciplines into the drug discovery process.
IAMI established an entrepreneurship training and education program for graduate and postdoctoral students in biomedical sciences and business administration at KU Medical Center. Read more »
Cultivating Medical Technology: IAMI's multi-disciplinary, multi-organizational project teams create rich, diverse scientific environments for translational scientists to foster innovation, enhance learning (not only of their own discipline but gaining knowledge of other disciplines in the process), create opportunities to engage patients in the development, demonstration and dissemination process and build entrepreneurship skills necessary to improve the quality of translational research conducted. In 2009, IAMI established an entrepreneurship training and education program available to graduate students in biomedical sciences and business administration, as well as postdoctoral trainees at KU Medical Center.
Success story: Two former IAMI Fellows, Karthik Ramachandaran, Ph.D., and Joshua Sestak, Ph.D., have created and currently lead successful Kansas-based startup companies, Likarda LLC and Orion Biosciences, Inc., respectively. Both startup companies have spun out medical innovation technologies supported by IAMI. Likarda, a One Health biotechnology company, has raised private capital investment and is currently generating service-based revenues. Orion has secured private investment and a Phase I Small Business Innovation Research grant and is currently advancing its first drug product.
In December 2008, IAMI was created with a mission to improve patient care by accelerating new drug therapies and medical devices to patients. Read more »
IAMI took this opportunity to focus on reformulating and repurposing approved drugs. This created rich collaboration across the University of Kansas campus, the Kansas City community and the nation.
Creating a fast track to new treatment is the pathway the Institute is developing within the motivational need to help people and improve patient care.
"What motivates us (the Institute) is not to develop the next big blockbuster drug but to apply our expertise to these problems and help children," Scott Weir, IAMI director.