Saturday, September 9, 2006
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| La Grande Motte Congress Center |
| 6:00 pm - 8:00 pm, Registration |
| 6:45 pm - 9:30 pm, Welcome Reception (open to all attendees) |
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Sunday, September 10, 2006
CHECK-IN/REGISTRATION: 8:00 am- 9:00 am
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OPENING PROCEEDINGS |
| Jonathan J. Li, Ph.D. & Suresh Mohla, Ph.D. (USA) |
| 9:00 am - 9:05 am, Welcome |
| Dinah Singer, Ph.D., Director, Division of Cancer Biology, NCI (USA) |
| 9:05 am - 9:10 am, Opening Remarks |
| Henri Rochefort, M.D., Ph.D. & Thierry Maudelonde, M.D., Ph.D. (FRANCE) |
| 9:10 am - 9:15 am, Speaker Introduction |
PLENARY SPEAKER |
| Suresh Mohla, Ph.D. (USA): |
| 9:20 am - 9:25 am, Speaker Inroduction |
| I. Bernard Weinstein, M.D. (USA) |
| 9:25 am - 10:15 am, “Oncogene Addiction: A Rationale for Novel Anticancer Drugs and Targets” |
| 10:15 am - 10:30 am, BREAK |
CELLULAR ORIGINS OF ENDOCRINE-RELATED CANCERS |
Chairpersons: Jonathan J. Li, Ph.D. (USA), Satyabrata Nandi, Ph.D. (USA)
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10:35 am - 10:40 am
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| Gilbert H. Smith, Ph.D. (USA): |
| 10:40 am - 11:10 am, “What About Stem Cells Marks Them Credible Candidates as Tumorigenic Targets?” |
| 11:10 am - 11:25 am, Discussion |
| Robert B. Clarke, Ph.D. (United Kingdom) |
| 11:25 am - 11:55 am, “The Origins of ER Positive and ER Negative Breast Cancer” |
| 11:55 am - 12:10 pm, Discussion |
| Hong Wu, M.D., Ph.D. (USA) |
| 12:10 pm - 12:40 pm, “PTEN, Prostate Cancer, and HRPC Development” |
| 12:40 pm- 12:45 pm, Discussion |
| 12:55 pm - 2:10 pm, Lunch |
SPECIAL LECTURE |
Vivian Pinn, M.D., Director, Office of Research on Women's Health (USA)(USA)
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2:10 pm - 2:50 pm, Women's Health Research: Perspectives from the National Institutes of Health
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MITOTIC KINASES, CENTROSOME AMPLIFICATION, AND GENOMIC INSTABILITY |
| Chairpersons: William R. Brinkley, Ph.D. (USA) & Jeffrey Salisbury, Ph.D. (USA) |
2:50 pm - 2:55 pm
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Wilma Lingle, Ph.D. (USA) |
| 2:55 pm - 3:25 pm, “Estrogen and Centrosome Amplification in Breast Cancer” |
| 3:25 pm - 3:40 pm, Discussion |
| Subrata Sen, Ph.D. (USA) |
| 3:40 pm - 4:10 pm, “Functional Significance of Aurora Kinase A in Centrosome Amplification & Genomic Instability” |
| 4:10 pm - 4:25 pm, Discussion |
| 4:25 pm - 4:40 pm, Break |
| Stefan Duensing, M.D. (USA) |
| 4:40 pm - 5:10 pm, “HPV-16 E7 and centriole duplication errors in cervical cancer: novel molecular insights and unexpected cellular mechanisms” |
| 5:10 pm - 5:25 pm, Discussion |
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Monday, September 11, 2006
STATE OF THE ART LECTURE |
| Michael F. Clarke, M.D. (USA) |
| 8:30 am - 9:15 am, “Self-renewal and Cancer Stem Cells” |
| 9:15 am - 9:30 am, Discussion |
NEW DEVELOPMENTS IN STEROID-RECEPTOR INTERACTIONS |
| Chairpersons: Elwood Jensen, Ph.D. (USA), Miguel Beato, M.D., Ph.D. (SPAIN) |
| 9:30 am - 9:35 am |
| Vincent Cavaillès, Ph.D. (FRANCE) |
| 9:35 am - 10:05 am, “Regulation of Hormone Signaling by Nuclear Receptor Interacting Proteins” |
| 10:05 am - 10:20 am, Discussion |
| 10:20 am - 10:40 am, Break |
| Raphael Metivier (FRANCE) |
| 10:40 am - 11:10 am, “Dynamics of ER-mediated Transcriptional Activation of a Responsive Gene In-vivo: Apprehending Transcription in Four Dimensions” |
| 11:10 am - 11:25 am, Discussion |
| Pascal Roger, M.D., Ph.D. (FRANCE) |
| 11:25 am- 11:55 am, “Estrogen Receptors Alpha and Beta Expression in Early Steps of Human Breast Carcinogenesis” |
| 11:55 am - 12:10 pm, Discussion |
| 12:10 pm – 1:25 pm, Lunch |
RISK ASSESSMENT AND RELEVANT EARLY BIOMARKERS |
Chairpersons: Pradip Roy-Burman, Ph.D. (USA) and Marileila Varella-Garcia, Ph.D. (USA)
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1:25 pm – 1:30 pm
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Ross L. Prentice, Ph.D., M.Sc., B.Sc. (USA) |
| 1:30 pm – 2:00 pm, “Women's Health Initiative Studies of Postmenopausal Hormone Therapy and Breast Cancer” |
| 2:00 pm – 2:15 pm, Discussion |
| Susan E. Hankinson, M.P.H., Sc.D. (USA) |
| 2:15 pm – 2:45 pm, “Endogenous Hormone Concentrations and Risk of Breast Cancer in Pre-menopausal Women” |
| 2:45 pm – 3:00 pm, Discussion |
| 3:00 pm – 3:15 pm, Break |
| Stephen G. Hillier, M.S., Ph.D., DSc, FRCPA (SCOTLAND) |
| 3:15 pm – 3:45 pm, “Ovulation and Ovarian Cancer” |
| 3:45 pm – 4:00 pm, Discussion |
| Elaine A. Ostrander (USA) |
| 4:00 pm – 4:30 pm, “Mapping Genes for Prostate Cancer Susceptibility” |
| 4:30 pm – 4:45 pm, Discussion |
| 6:00 pm – 8:30 pm, Tour of the 12th century Faculty of Medicine and cocktail (Open to all attendees) |
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Tuesday, September 12, 2006
STATE OF THE ART LECTURE |
| Gordon Mills, M.D., Ph.D. (USA) |
| 8:30 am - 9:15 am, “Ovarian Cancer: Linking Genomics to New Target Discovery and Molecular Markers: The Way Ahead” |
| 9:15 am - 9:30 am, Discussion |
NOVEL STRATEGIES FOR PREVENTION & TREATMENT OF ENDOCRINE-RELATED CANCERS |
| Chairpersons: James Pickar, M.D. (USA) and Shutsung Liao, Ph.D. (USA) |
| 9:30 am - 9:35 am |
| Christopher J. Logothetis, M.D. (USA) |
| 9:35 am - 10:05 am, “Novel Strategies to Treat Prostate Cancer” |
| 10:05 am - 10:20 am, Discussion |
| 10:20 am - 10:40 am, Break |
| Anthony Howell, M.B.B.S. (UNITED KINGDOM) |
| 10:40 am - 11:10 am, “Endocrine Prevention and Treatment of Breast Cancer” |
| 11:10 am - 11:25 am, Discussion |
| Sara Antonia Li, Ph.D. (USA) |
| 11:25 am- 11:55 am, “Estrogen-induced Oncogenesis: Modulation by an Aurora Kinase Inhibitor” |
| 11:55 am - 12:10 pm, Discussion |
| 12:10 pm – 1:25 pm, Lunch |
SPECIAL LECTURE |
Henri Rochefort, M.D., Ph.D. (FRANCE) |
1:25 pm – 1:30 pm, Speaker introduction
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Satyabrata Nandi, Ph.D. (USA) |
1:30 pm – 2:05 pm, Breast Cancer Biology: Conceptions, Misconceptions and new Concepts
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POSTER PRESENTATIONS |
2:10 pm - 4:30 pm, Poster Presentations |
Oral Poster Presentation I Chairpersons: Sara Antonia Li, Ph.D. (USA) & Thierry Maudelonde, M.D., Ph.D. (FRANCE)
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| 4:30 pm – 4:40 pm, “The Curious Pharmacology of the Antiestrogens'," Elwood Jensen, Ph.D. (USA) |
| 4:40 pm – 4:43 pm, Discussion |
| 4:43 pm – 4:53 pm, “Identification of Downstream Targets of Estrogen and c-Myc in Breast Cancer Cells," Elizabeth Musgrove, Ph.D. (AUSTRALIA) |
| 4:53 pm – 4:56 pm, Discussion |
Oral Poster Presentation II Chairpersons: Zoran Culig, M.D. (AUSTRIA) & Albert Brinkmann, Ph.D. (NETHERLANDS)
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| 4:56 pm – 5:06 pm, “Inactivation of Id-1 Gene Induces Sensitivity of Prostate Cancer Cells to Chemotherapeutic Drugs," Y.C. Wong, Ph.D. (CHINA) |
| 5:06 pm – 5:09 pm, Discussion |
| 5:09 pm – 5:19 pm, “Molecular Signatures Of Estrogen Receptor-Associated Genes In Breast Cancer Predict Clinical Outcome," James Wittliff, Ph.D. (USA) |
| 5:19 pm – 5:22 pm, Discussion |
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Wednesday, September 13, 2006
STATE OF THE ART LECTURE |
| Claude Prigent, Ph.D. (FRANCE) |
| 8:30 am - 9:15 am, “Aurora, Polo, Nek, Cdk1 the Mitotic Bodyguards” |
| 9:15 am - 9:30 am, Discussion |
HORMONE DEPENDENCY VERSUS HORMONE INDEPENDENCY |
| Chairpersons: Etienne Baulieu, M.D. (FRANCE) and Donald Tindall, Ph.D. (USA) |
| 9:30 am - 9:35 am |
| James Mohler, M.D. (USA) |
| 9:35 am - 10:05 am, “Recurrent Prostate Cancer is not Androgen-Independent” |
| 10:05 am - 10:20 am, Discussion |
| 10:20 am - 10:40 am, Break |
| Jean-Marc Vanacker, Ph.D. (FRANCE) |
| 10:40 am - 11:10 am, “Estrogen-Receptor Related (ERR) Alpha Orphan Receptor and Hormone Signaling” |
| 11:10 am - 11:25 am, Discussion |
| Nancy Weigel, Ph.D. (USA) |
| 11:25 am- 11:55 am, “Androgen Receptor and Co-regulator Action in Hormone Dependent and Hormone Independent Prostate Cancer” |
| 11:55 am - 12:10 pm, Discussion |
| 12:10 pm – 1:30 pm, Lunch |
EMERGING FIELDS: HORMONES & COLORECTAL AND LUNG CANCERS |
| Chairpersons: Janet Daling, Ph.D. (USA) and Henri Rochefort, M.D., Ph.D. (FRANCE) |
| 1:25 pm – 1:30 am |
| Polly A. Newcomb, Ph.D., MPH (USA) |
| 1:30 pm - 2:00 pm, “Why Hormones Protect Against Colorectal Cancer: Old Ideas, New Evidence” |
| 2:00 pm - 2:15 pm, Discussion |
| Alberto Muñoz, Ph.D. (SPAIN) |
| 2:15 pm – 2:45 pm, “Vitamin D and Colon Cancer” |
| 2:45 pm - 3:00 pm, Discussion |
| 3:00 pm - 3:20 pm, Break |
| Diana C. Márquez-Garbán, M.D. (USA) |
| 3:20 pm – 3:50 pm, “Estrogen Signaling Pathways in Human Lung Cancer" |
| 3:50 pm - 4:05 pm, Discussion |
CLOSING REMARKS |
Suresh Mohla, Ph.D. (USA) |
4:05 pm – 4:15 pm, Closing Remarks
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Social Program Schedule
Saturday, September 9, 2006 |
| La Grande Motte Congress Center |
| 6:00 pm - 8:00 pm, Registration |
| 6:45 pm - 9:30 pm, Welcome Reception (open to all attendees) |
Monday, September 11, 2006 |
| La Grande Motte Congress Center |
6:00 p.m. – 8:30 p.m., Visit of the 12th century Faculty of Medicine of Montpellier with a cocktail. Open to all attendees and guests
Symposium attendees: Take a shuttle from the Congress Center after last presentation
Guests/Spouses: Walk to the Faculty of Medicine after the tour of Historic Montpellier is over.
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Tuesday, September 12, 2006 |
| Symposium Dinner at Le Chteau de Pouget |
7:00 p.m. – 8:30 p.m., Symposium Dinner at Le Chteau de Pouget
Depart from La Grande Motte Congress Center
Open only to Registered Guests/Spouses
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Tours for Registered Guests/Spouses |
| Monday, September 11, 2006 |
3:00 p.m. – 5:00 p.m., Guided tour of Historic Montpellier and shopping time
Depart from La Grande Motte Congress Center
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| Tuesday, September 12, 2006 |
1:30 p.m. – 5:30 p.m., Visit of Saint Guilhem Le Desert (typical Middle Ages village)
Depart from La Grande Motte Congress Center
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