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Speakers

Carlos

Carlos Moraes, PhD
University of Miami Miller School of Medicine

Symposium Title: Manipulating mtDNA in vivo with DNA editing enzymes

Carlos Moraes earned his PhD from Columbia University, where his research identified mitochondrial DNA mutations in patients with ocular myopathies. Dr. Moraes’ completed postdoctoral training at Columbia University and accepted a position at the University of Miami in 1993. He is currently the Lichtenstein Professor of Neurology and Cell Biology at the University of Miami Miller School of Medicine. Dr. Moraes’ work has continued to define novel mitochondrial DNA mutations across multiple clinical phenotypes. His research focus includes developing genetic approaches for treatment of mitochondrial diseases, understanding the interaction between mitochondria and the nucleus, and mitochondria in aging and neurodegeneration.

Faculty Profile

https://moraeslab.weebly.com/

Holly

Holly Van Remmen, PhD
Oklahoma Medical Research Foundation

Holly Van Remmen earned her PhD from the University Of Texas Health Science Center (UTHSC) in 1991. Her postdoctoral training was completed in 1995 under the direction of Arlan Richardson at UTHSC. She joined the Oklahoma Medical Research foundation in 2013, where she is a program chair for the Aging and Metabolism Research Program. Dr. Van Remmen is the leader of the Integrative Redox Biology Core of the Oklahoma Nathan Shock Center for Aging Research. Dr. Van Remmen's research focus is on oxidative stress and mitochondrial function in muscle loss, aging, and metabolism.

https://omrf.org/research-faculty/scientists/van-remmen-holly/

https://vanremmen.omrf.org/

Darley-Usmar

Victor M. Darley-Usmar, PhD
Associate Dean for Research Endowed Professor in Mitochondrial Medicine and Pathology

Symposium Title: The Potential of Translational Bioenergetics for Precision Medicine

Victor Darley-Usmar received his Ph.D. at the University of Essex in England and then moved to the University of Oregon as a Post-Doctoral Fellow to pursue his interests in the structure and function of mitochondrial proteins in human disease. After a period as a lecturer in Japan and ten years as a Research Scientist in Burroughs Wellcome in London he joined UAB to establish his own research group in the Department of Pathology in 1995.  He has received multiple awards for training and mentoring and served as the Associate Dean for Post-Doctoral Education and the Pathology Graduate Program Director.  He established the UAB Center for Free Radical Biology from 2006-2015 as an international center for research in redox biology. In his own research program he has been instrumental in defining how redox biology modifies mitochondrial function in pathology and in recognition of these achievements was awarded a Lifetime Achievement Award by the Society for Free Radical Biology and Medicine in 2012At UAB his contribution to research in mitochondrial pathology was recognized by his appointment as the Foundation Faculty for the "Endowed Professorship in Mitochondrial Medicine and Pathology".  He is now developing a program to apply measures of bioenergetic health to personalized medicine.  He was a recent recipient of the prestigious "Creativity is a Decision" and "Blue Sky" awards from UAB for the Bioenergetic Health Index concept. He was recently recognized as the 2017 UAB Distinguished Faculty Lecturer, which is is the highest honor bestowed by the Academic Medical Center on a faculty member who has advanced the frontiers of science and made outstanding contributions to education, research and public service.

https://www.uab.edu/medicine/diabetes/faculty/faculty-bios/93-victor-darley-usmar

Andrews

Shea Andrews, PhD
Icahn School of Medicine at Mount Sinai

Symposium Title: Mitochondrial haplogroups and a nuclear encoded mitochondrial polygenic risk score interact to influence dementia risk

Shea Andrews earned his PhD in Medical Sciences at the Australian National University (ANU), followed by a postdoctoral research fellowship at ANU. Dr. Andrews is currently a postdoctoral researcher at the Icahn School of Medicine at Mount Sinai, where he works in the laboratory of Dr. Alison Goate. His training encompasses molecular genetics, genetic epidemiology, and neuro-quantitative methods. Dr. Andrews' research is focused on elucidating the role of genetic and non-genetic risk factors in Alzheimer's disease (AD), with an emphasis on revealing and understanding associations between multiple modalities of risk and protective factors in cognition and aging. He recently developed a technique to calculate mitochondrial nuclear gene polygenic risk scores for AD, which has been applied to GWAS-analyzed AD cohorts and which reveals interactions between nuclear DNA encoded mitochondrial and mitochondrial DNA encoded variants.

Scarpulla

Richard Scarpulla, PhD
Northwestern Feinberg School of Medicine

Richard Scarpulla received his PhD in Molecular Biology from the Albert Einstein College of Medicine in 1978. He completed his postdoctoral training in Biochemistry, Molecular and Cell Biology at Cornell University and was appointed Assistant Professor of Molecular Biology at Northwestern Medical School in 1982 where he is currently Professor of Cell and Molecular Biology. Current work in Dr. Scarpulla's lab combines molecular and biochemical approaches with the development of cellular and transgenic models to understand the regulatory mechanisms governing nucleo-mitochondrial interactions.

http://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=13356

Shirihai

Orian Shirihai, MD PhD
University of California Los Angeles, David Geffen School of Medicine

Symposium Title: Mitochondrial Dynamics In Quality control, Fuel Preferences and Energy Expenditure

Orian Shirihai completed his MD and PhD training at the Technion, Israel Institute of Technology in 1997. He then did a post doctoral fellowship at Harvard Medical School in 1997. In 2000 he was recruited to start his lab at the Marine Biological Laboratory in Woods Hole, MA. In 2004 Shirihai he returned to Boston to start a mitochondria research program at Tufts University and then in 2008 his lab was recruited to Boston University where he established the Mitochondria Affinity Research Collaboration, The Bioenergetics Core and the Cellular Imaging Core of Boston University. In 2016 Shirihai and his lab were recruited to UCLA where he is heading UCLA Metabolism Research Theme and UCLA Mitochondria and Bioenergetics Core. In 2018 Shirihai established EnspireBio, a biotech dedicated to the promotion of an array of inventions by UCLA scientists, co-owned by PIs and trainees, and based on team work within UCLA Metabolism Theme. Dr. Shirihai research is focused on mechanisms by which mitochondria regulate energy expenditure and fuel preference. His lab is known for the description of the mitochondria life cycle involving an axis of fusion, fission and mitophagy as a quality control mechanism, a process playing a central role in aging associated diseases.

http://medschool.ucla.edu/metabolism/about

Last modified: Jul 26, 2018
Contact

Heather Wilkins
hwilkins@kumc.edu

Ian Weidling
iweidling2@kumc.edu

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