Spring 2006

Date

Time

Speaker

Title

Jan 13	11:00 am	Gregory Petsko, Ph.D. Brandeis University	On the Origin of Enzymatic Species: How New Enzymes Evolve from Old Ones
Jan 20	11:00 am	R. John Collier, Ph.D. Harvard Medical School	Anthrax Toxin: Mechanism of Membrane Translocation
Jan 27	11:00 am	Jay Vivian, Ph.D. University of Kansas Medical Center	Genetic Screens in Mouse Embryonic Stem Cells
Feb 3	11:00 am	Paul E. Smith, Ph.D. Kansas State University	Computer Simulation of the Delta Opioid Receptor and Delta Opioid Receptor Selective Peptide Agonists
Feb 10	11:00 am	Canceled
Feb 17	11:00 am	Page Geiger, Ph.D. University of Kansas Medical Center	Exercise Training in the Prevention of Insulin Resistance and Type 2 Diabetes: A Cellular Approach
Feb 24	11:00 am	Vincent J. Hilser, Ph.D. University of Texas Medical Branch	What's in a Protein Ensemble
Mar 3	11:00 am	Dorothy Beckett, Ph.D. University of Maryland	Regulating the Regulators; Control of Transcription Repression Complex
Mar 10	11:00 am	A. L. Burlingame, Ph.D. University of California San Francisco	The Challenge of Defining Protein Postranslational Complexity Using Mass Spectrometry
Mar 17	11:00 am	John M. Tomich, Ph.D. Kansas State University	"Redesigning Nature: Studies on New Channel-Forming Sequences Derived from the Second Transmembrane Segment of the Glycine Receptor-Subunit"
Mar 24	11:00 am	No Seminar - Spring Break
Mar 31	11:00 am	Hao Zhu, Ph.D. University of Kansas Medical Center	"NCB5OR, Oxidative Stress and Diabetes"
Apr 7	11:00 am	Roberto De Guzman, Ph.D. University of Kansas - Lawrence	"NMR Studies of Proteins Involved in Bacterial and Viral Pathogenesis"
Apr 14 Lied Aud.	11:00 am	C. Robert Matthews, Ph.D. University of Massachusetts Medical School Note change of location to Lied Auditorium	"Are protein folding mechanisms better conserved than their amino acid sequences? The roles of topology and sequence in controlling the folding mechanisms of TIM barrel proteins"
Apr 21	11:00 am	Joyce A. Lloyd, Ph.D. Virginia Commonwealth University	"Globin Gene Regulation: Bottom-Up and Top-Down Approaches"
Apr 28	11:00 am	Malin M. Young, Ph.D. Sandia National Laboratories	"Protein Structural characterization using chemical cross-linking, mass spectrometry and modeling"
May 5	11:00 am	Canceled
May 12	11:00 am	Jackob Moskovitz, D.Sc. University of Kansas - Lawrence	"The methionine sulfoxide reductase system and its role in antioxidant defense and survival"
May 19	11:00 am	Andrew D. Robertson, Ph.D. University of Iowa	"Structural Consequences of Insertions Among Ubiquitin-Like Proteins

Fall 2005

Date

Time

Speaker

Title

Sept 9	11:00 am	Jinxi Wang, M.D., Ph.D. Orthopedics, University of Kansas Medical Center	Enhancement of Skeletal Repair by Biochemical & Molecular Means
Sept 16	11:00 am	Henry Miziorko, Ph.D. University of Missouri - Kansas City	HMG-CoA Synthase: Functional Correlations and a Reversal of Expectations
Sept 23	11:00 am	Michael Washburn, Ph.D. Stowers Institute, Kansas City	Quantitative Proteomic Analysis via MudPIT
Sept 30	11:00 am	Li Wang, Ph.D. University of Kansas Medical Center	'Orphan' but not lonely: how much can nuclear receptor SHP do?
Oct 7	11:00 am	No Seminar - SOM Faculty Retreat
Oct 14	11:00 am	John Laity, Ph.D. University of Missouri-Kansas City	Are we full of Zinc? Binding and structural studies of metalloregulatory domains from MTF-1 and Zap1
Oct 21	11:00 am	George Reed, Ph.D. University of Wisconsin	Encolase. A Jewel in the Crown of Glycolysis
Oct 28	11:00 am	T. Chris Gamblin, Ph.D. University of Kansas - Lawrence	Modeling Neurodegenerative Tauopathies In Vitro
Nov 4	11:00 am	David Toft, Ph.D. Mayo Clinic	Chaperoning Cell Regulatory Proteins through Hsp90
Nov 11	11:00 am	Yeon-Kyun Shin, Ph.D. Iowa State University	Intermediates in SNARE-Mediated  Membrane Fusion
Nov 18	11:00 am	Madeline A. Shea, Ph.D. University of Iowas	Calmodulin Regulation: A Tale of Two Domains
Nov 25	11:00 am	No Seminar - Holiday
Dec 2	11:00 am	Joseph Fontes, Ph.D. Faculty Candidate	The ZXD family: Novel regulators of MHC II transcription
Dec 5	8:30 - 10:00 a.m.	Jeremy Sanford, Ph.D. Faculty Candidate note new location: Lied Auditorium	Getting the message: RNA binding proteins and post-transcriptional gene expression
Dec 6	9:00 am	Steve Patrick, Ph.D. Faculty Candidate note new location: 1014 Orr Major	Biochemical Processing of Cisplatin-DNA Interstrand Cross-links (ICLs)
Dec 9	11:00 am	Felix Koberling PicoQuant, Berlin, Germany Special Seminar	Time-resolved Confocal Fluorescence Microscopy: Novel Technical Features and Applications for FLIM, FRET and FCS"
Dec 16	11:00 am	Scott Warder, Ph.D. Abbott Labs	Discovery of Protein Markers for Pharmaceutical Drug Development

Spring 2005

Date

Time

Speaker

Title

Jan 14	11:00 am	Jonathan Silberg, Ph.D. Rice University	"On the conservative nature of protein recombination"
Jan 21	11:00 am	Sue Jaspersen, Ph.D. University of Colorado, Boulder	"Yeast Centrosomes: Structure, Duplication and Function"
Jan 28	11:00 am	Chris Lorson, Ph.D. University of Missouri - Coloumbia	"The Role of Survival Motor Neuron (SMN) in the Development of Spinal Muscular Atrophy"
Feb 4	11:00 am	Michal Zolkiewski, Ph.D. Kansas State University	"Structure and Function of ClpB: a Protein-Disaggregating Molecular Chaperone"
Feb 11	11:00 am	Emily Scott, Ph.D. University of Kansas-Lawrence	"Structure and Function of Cytochrome P450s involved in Xenobiotic Metabolism"
Feb 18	11:00 am	Xiao-Qiang (Sean) Yu, Ph.D. University of Missouri - Kansas City	"Lectins in innate immune responses of an insect"
Feb 25	11:00 am	Deborah S. Wuttke, Ph.D. University of Colorado	"Tying up the Ends: Recognition of Single-Stranded DNA at Telomeres"
Mar 11	11:00 am	Mario Ernesto Rivera-Laos, Ph.D. University of Kansas - Lawrence	"Heme Oxygenase in Pathogenic Bacteria: Insights from Magnetic Resonance Investigations of the Active Site"
Mar 18	11:00 am	Yu-Jui Yvonne Wan, Ph.D. Dept of Pharmacology, Toxicology & Therapeutics, KUMC	"Functional Analysis of Retionoid X receptor alpha in Hepatocyte"
Apr 1	11:00 am	Don G. Ennis, Ph.D. University of Louisiana - Lafayette	"Development of a Mutagenesis Assay in Transgenic Animals: Investigations of Chronic Infections and Carcinogenesis"
Apr 8	11:00 am	Frederick Sachs, Ph.D. Hughes Center for Single Molecule Biophysics	"Mechanosensitive ion channels: from bench to bedside"
Apr 15	11:00 am	Richard Honzatko, Ph.D. Iowa State University	"Ligand Cooperativity in Fructose-1,6-bishoshpatase"
Apr 22	11:00 am	Philip J. Thomas, Ph.D. UT Southwester Medical Center at Dallas	"Cystic Fibrosis:  Disease of Altered Protein Folding"
Apr 29	11:00 am	Thomas Nowak, Ph.D. University of Notre Dame	"Fundamental Steps in Pyruvate Kinase: Phosphoryl Transfer and Enolpyruvate Protonation"
May 6	11:00 am	Patrick Loria, Ph.D. Yale University	"Conversation and Control of Enzyme Dynamics for Optimal Catalysis"
May 13	11:00 am	Jill Trewhella, Ph.D. Dept of Chemistry, University of Utah,	Structural Themes and Variations in Kinase Activation and Targeting

---

Fall 2004 

Date

Time

Speaker

Title

Sept 10	11:00 am	Liskin Swint-Kruse, PhD. Dept of Biochemistry & Molecular Biology, KUMC	"Tools to identify functionally relevant fine details in protein structure"
Sept 24	10:00 am Lied Aud.	Carey Johnson, PhD Dept of Chemistry University of Kansas - Lawrence	"Single-Molecule Spectroscopy of Calcium Signaling: Dynamics and Target Interactions of Calmodulin"
Oct 8	11:00 am	David Mount, Ph.D. University of Arizona	"Cancer Bioinformatics: support for the discovery of new drugs and diagnostic tools"
Oct 15	11:00 am	Rolf Jakobi, Ph.D. Kansas City University of Medicine and Biosciences	"The Role of p21-Activated Protein Kinase2 in Cell Survival and Cell Death"
Oct 22	11:00 am	Karen G. Fleming, Ph.D. Johns Hopkins University	"Membrane Protein Interactions: Thermodynamics in the Role of Sequence Motifs"
Oct 29	11:00 am	Edith Chang, Ph.D. Kansas City University of Medicine and Biosciences	"The Role of cyclooxygenase 2 in Cell Survival, Cell Motility and Colon Cancer Development"
Nov 5	11:00 am	Anthony L. Fink, Ph.D. University of California, Santa Cruz	"The molecular basis for ß-synuclein fibrillation: Implications for Parkinson's Disease"
Nov 12	11:00 am	Greg Reinhart, Ph.D. Texas A&M	"Using Fluctuation Spectroscopy to Study Protein-Protein Interactions"
Nov 19	11:00 am	Art Johnson, Ph.D Texas A&M	"Maintenance of Membrane Integrity by Ribosomes, BiP, and Translocons during ER Protein Trafficking"
Nov 26	11:00 am	No Seminar Thanksgiving Holiday
Dec 3	11:00 am	John Robertson, Ph.D. Dept of Pharmacology & Toxicology, KUMC	"Caspase-2-mediated engagement of the mitochondrial apoptotic pathway"
Dec 10	11:00 am	Sarah Bondos, Ph.D. Rice University	"Integrating Information: Hox Proteins physically and genetically interact with proteins from an array of cellular systems"
Dec 17	11:00 am	Audrey Lambs, Ph.D. University of Kansas-Lawrence	"Siderophore Biosynthesis by Pseudomonas aeruginosa"

Spring 2004 

Date	Time	Speaker	Title
Jan 23	11:00 am	Gerald J. Wyckoff, Ph.D. University of Missouri-Kansas City	"Conservation Does Not Equal Constraint"
Jan 30	11:00 am	Chunying Du, Ph.D. Stowers Institute, KCMO	"To die or not to Die: Regulation of Apoptosis"
Feb 20	11:00 am	William A. Cramer, Ph.D. Purdue University	"Searching the Caves inside an integral membrane transport protein: the cytochrome b6f complex of oxygenic photosynthesis"
Feb 27	11:00 am	Ron Rubenstein, MD, Ph.D, University of Pennsylvania	"Tales from the Mutant CFTR Repair Shop"
Mar 5	11:00 am	Bryan Copple, Ph.D, Dept of Pharmacology, Toxicology and Therapeutics, KUMC	"Hepatocellular Injury Produced by the Pyrrolizidine Alkaloid Plant Toxin Monocrotaline: a Potential Role for Hypoxia"
Mar 12	11:00 am	Dennis Thiele, Ph.D. Duke University Medical Center	"Copper in Signaling, Growth and Development and Disease"
Mar 19	11:00 am	Christophe Nicot  Dept of  Microbiology, KUMC	"HTLV-I regulatory proteins in viral persistence"
Apr 9	11:00 am	Ajay Rana, Ph.D. Texas A&M Univ. Health System	"Role of Mixed Lineage Kinase 3 in JNK Activation and Beone"
Apr 16	11:00 am	Nilofer Qureshi, Ph.D. University of Missouri - Kansas City	"The Proteasome, a central regulator of inflammation and macrophage function"
Apr 23	11:00 am	Samson T. Jacob, Ph.D. Ohio State University	"Methylation and silencing of a novel candidate tumor suppressor gene in animal and human tumors: functional and clinical implications"
Apr 30	11:00 am	D.A. Butterfield, Ph.D. University of Kentucky	"Oxidative Stress and Neurodegeneration in Alzheimer's Disease Brain: Central Role of Amyloid Beta-Peptide 1-42"
May 7	11:00 am	Mona T. Norcum, Ph.D. University of Mississippi Medical Center	"Structure of Aminoacyl-tRNA Synthetase Complexes: Mapping of Enzyme Positions via Three-dimensional Electron Microsopy"

Fall 2003 

Date	Time	Speaker	Title
Aug 22	12 Noon	Liskin Swint-Kruse, Ph.D Rice University, Houston, TX	"A multidisciplinary approach to the structure/function relationship of a genetic regulatory protein"
Sep 26	11:00 am	Susan Martinez, Ph.D. University of Houston	"Leucyl-t RNA Synthetase-dependent Splicing and Amino Acid Editing by a Multi-functional tRNA Synthetase"
Oct 10	11:00 am	Vadim N. Gladyshev, Ph.D. Department of Biochemistry, University of Nebraska	"Identity and functions of selenium-containing proteins."
Oct 17	11:00 am	Gary Ackers Washington University	"Surprising New Understanding of Hemoglobin Cooperativity"
Oct 24	11:00 am	Kathi Glauner, Ph.D. University of Kansas Medical Center	"Control of  Nociception: Ellucidating the effect of channel modification:
Oct 31	11:00 am	John Laity, Ph.D. University of Missouri-Kansas City	"New Paradigms for Zinc Finger Structure and Function"
Nov 14	11:00 am	Peter Baumann, Ph.D. Stowers Institute, KCMO	"Chromosome Ends and Genome Stability"
Dec 5	11:00 am	Jennifer Gerton, Ph.D. Stowers Institute, KCMO	"Genome-wide mapping of the cohesin complex in S. Cerevisiae"
Dec 12	11:00 am	Huimin Jiang University of Kansas Medical Center	TBA

Spring 2003 Formal Seminars

Date	Time	Speaker	Title
Apr 25	11:00 am	Hermant K. Paudel, Ph.D.  McGill University, Montreal, Canada	Phosphorylation of microtubule-associate protein tau and neurofibrillary pathology of Alzheimer's disease
May 8	11:00 am	Anthony Persechini, Ph.D.   University of Missouri-Kansas City	Molecular and Cellular Aspects of Signaling Through Calmodulin
May 16	11:00 am	Stephen King, Ph.D. University of Missouri-Kansas City	Dynein and dynactin: interactions required for motility

Fall 2002 Formal Seminars
no seminars were held during fall semester, 2002

Spring 2002 Formal Seminars

Date	Time	Speaker	Title
Friday, January 18, 2002	11:00 AM	Roy Zent, Ph.D., Vanderbilt University Medical Center	"Integrin signaling in branching morphogenesis"
Friday, January 25, 2002	11:00 AM	Susan M. Egan, Ph.D., University of Kansas-Lawrence	"Transcription activation of the E.coli L-rhamnose genes"
Friday, February 1, 2002	11:00 AM	Robert E. Palazzo, Ph.D., University of Kansas-Lawrence	"Centrosome Assembly and Maturation: Boveri Revisited!"
Friday, February 8, 2002	11:00 AM	Ting Xie, Ph.D., Stowers Institute for Medical Research	"Molecular Mechanisms Regulating Germline Stem Cells in the Drosophila Ovary"
Friday, February 15	11:00 AM	Robert Cohen, Ph.D., University of Kansas-Lawrence	"Patterning the Fly egg: RNA localization, translational control and membrane trafficking"
Friday, February 22, 2002	11:00 AM	Leonard Dobens, Jr., Ph.D., University of Missouri-Kansas City	"The role of Drosophila 'bunched', a homologue of the mouse transcription factor YSC-22, in cell fate boundary formation"
Friday, March 8, 2002	11:00 AM	Vytas Bankaitis, Ph.D., University of North Carolina	"Phosphatidylinositol Transfer Protein Function and Neurodegenerative Disease in Mice"
Friday, March 29, 2002	11:00 AM	G. Sullivan Read, Ph.D., University of Missouri - Kansas City	"mRNA decay during herpesvirus infections:  Interactions between a viral mRNase and cellular translation factors"
Friday, April 12, 2002	11:00 AM	Scott Falke KUMC Doctoral Candidate	"Two-Stroke Folding Machines: A review of allosteric mechanisms guiding chaperonin-facilitated protein folding"
Friday, April 19, 2002	11:00 AM	William M. Atkins, Ph.D., University of Washington	"Structure, Function, and Therapeutic Aspects of Glutathione S-transferases"
Friday, April 26, 2002	11:00 AM	Jeffrey Urbauer, Ph.D., University of Kansas-Lawrence	"Solution Structure and Function of the Anti-Sigma Factor AsiA"

Fall 2001 Formal Seminars

Date	Time	Speaker	Title
Friday, September 14, 2001	11:00 AM	Tim M. Townes, Ph.D., University of Alabama at Birmingham	"Human Globin Gene Regulation and Genetic Therapies for Sickle Cell Disease"
Friday, September 21, 2001	11:00 AM	No Seminar-Faculty Retreat
Friday, September 28, 2001	11:00 AM	Linheng Li, Ph.D., Stowers Institute	"Hematopietic Stem Cell Development"
Friday, October 19, 2001	11:00 AM	James A. Coffman, Ph.D., Stowers Institute	"Transcription factors that control cell proliferation and differentiation in the sea urchin embryo"
Friday, October 26, 2001	11:00 AM	Patrice Delafontaine, M.D., KUMC	"IGF-1 in Cardiovascular Disease"
Friday, November 16, 2001	11:00 AM	Jeffrey Price, Ph.D., UMKC	"The double-time protein kinase determines the duration of both the nuclear and cytoplasmic phases of a molecular circadian oscillator"
Friday, November 30, 2001	11:00 AM	Patrick S. Stayton, Ph.D., University of Washington	"Biomaterials That Talk and Listen"
Friday, December 7, 2001	11:00 AM	Joan Conaway, Ph.D., Stowers Institute	"Elongin BC-based ubiquitin ligases and transcriptional regulation?
Friday, December 14, 2001	11:00 AM	Natalia Y. Kedishvili, Ph.D., UMKC

Spring 2001 Formal Seminars

Date	Time	Speaker	Title
Friday, January 5, 2001	11:00 AM	Saul M. Honigberg, Ph.D., UMKC	"Cell Cycle and Glucose Repression Pathways converge in Transcriptional Control of Meiosis in Yeast"
Friday, January 12, 2001	11:00 AM	Michael Herman, Ph.D.,  K-State University	"Control of Cell Polarity and Cell Migration by Wnt Signaling in C. elegans"
Friday, January 19, 2001	11:00 AM	Tom Menees, Ph.D.,  UMKC	"Yeast Ty Retrotransposons as a Model for Studying Retroelement/Host Interactions in Eukaryotes"
Friday, January 26, 2001	11:00 AM	Christian Schoneich, Ph.D.,  Univ. of Kansas	"When Radicals React With Proteins: Theory, Aging and Pathology"
Friday, February 2, 2001	11:00 AM	Joe Lutkenhaus, Ph.D., Microbiology - KUMC	"Spatial Regulation of Cell Division in E. Coli"
Friday, February 16, 2001	11:00 AM	Curtis D. Klaassen, Ph.D., Pharmacology - KUMC	"Regulation of Xenobiotic Transporters in the Liver"
Friday, March 2, 2001	11:00 AM	Peter C. Harris, Ph.D., Mayo Medical School	"Genetic Studies of Polycycstic Kidney Disease"

Fall 2000 Formal Seminars

Date	Time	Speaker	Title	Sponsor
Friday, September 8, 2000	11:00 am	Harvey Fisher, Ph.D., VA Medical Center, KUMC	"A close-packed four-atom square motife serves as a variable-pathway mechanistic switching device in enzymatic catalysis"
Friday, September 15, 2000	11:00 am	Chi-Chung Chan, Ph.D., Merck	"Discovery of the Selective COX-2 Inhibitor Rofecoxib"	Dr. Milton Noelkin
Friday, September 22, 2000	11:00 am	Jim Karam, Ph.D., Tulane University Health Sciences Center	"Regulation of pol-alpha DNA polymerase by RNA"	Dr. Billy G. Hudson
Friday, September 29, 2000	11:00 am	Bruce Roe, Ph.D., University of Oklahoma	"The Human Genome Project: The complete sequence of the first of 23 human chromosome pairs, human chromosome 22"	Dr. Allen Rawitch
Friday, October 6, 2000	11:00 am	Edward Eisenstein, Ph.D., University of Maryland Biotech Inst.	"A Structural Approach for Determining the Biological Roles of Proteins of Unknown Function: Problems and Prospects"
Friday, October 13, 2000	11:00 am	Robert C. DeLisle, Ph.D., Anatomy and Cell Biology, KUMC	"Posttranslational processing and intracellular trafficking of pro-Muclin, a putative Golgi cargo receptor"
Friday, October 20, 2000	11:00 am	Ethan Taylor, Ph.D., University of Georgia	"HIV-1 encodes a sequence with functional glutathioneperoxidase activity: implicatioons for mechanisms of HIV pathogenesis"	Dr. Wilfred Arnold
Friday, October 27, 2000	11:00 am	Francois Baneyx, Ph.D., University of Washington	"Chaperone-assisted protein folding in the cytoplasm of E. coli"	Dr. Mark Fisher
Friday, November 3, 2000	11:00 am	Masahiko Sato, Ph.D., Laval University, Canada	"Functional roles of poly(ADP-ribose) polymerase in cellular damage responses"
Friday, November 10, 2000	11:00 am	No Seminar - Holiday
Friday, November 17, 2000	11:00 am	Scott C. Stodd, Ph.D., K-State University	"The Regulations of Cell Adhesion and Migration by Tetraspanins"
Friday, November 24, 2000	11:00 am	No Seminar - Holiday
Friday, December 1, 2000	11:00 am	Phil Hanawalt, Ph.D., Stanford University	"Regulation of Excision Repair of DNA in Mammalian Cells"	Dr. Hiroaki Sewizawa
Friday, December 8, 2000	11:00 am	Paul F. Terranova, Ph.D., Physiology, KUMC	"Mechanisms of Tumor Necrosis Factor Inhibition of Ovarian Steroidogenesis"
Friday, December 15, 2000	11:00 am	Rollie J. Clem, Ph.D., K-State University	"Regulation of Apoptosis by Baculoviruses"

Spring 2000 Formal Seminars

Date	Time	Speaker	Title	Faculty Sponsor
Friday, January 7, 2000	11:00 AM	Michelle David University of Kansas Medical Center	Identification of critical Amino Acid Residues Comprising the Goodpasture Epitope	Billy G. Hudson, Ph.D.
Friday, January 28, 2000	11:00 AM	Ali Shilatifard, Ph.D.       St. Louis University School of Medicine	The RNA Polymerase II Regulating Factors, Their Roles in Mammalian Cells and in Human Cancer	Hiroaki Serizawa, Ph.D.
Friday, February 4, 2000	11:00 AM	Tohru Kozasa, Ph.D. The University of Illinois at Chicago	RGS proteins:key regulators of G-protein signaling pathways	Hiroaki Serizawa, Ph.D.
Friday, February 11, 2000	11:00 AM	Doug Wright, Ph.D. University of Kansas Medical Center	Trophic Therapies for Neuropathic Sensory Neurons	Hiroaki Serizawa, Ph.D.
Friday, February 18, 2000	11:00 AM	Michael P. Sarras, Ph.D. University of Kansas Medical Center	Role of Cell/Extracellular Matrix Interactions during Pattern Formation and Morphogenesis	Hiroaki Serizawa, Ph.D.
Friday, February 25, 2000	11:00 AM	Opendra Narayan, Ph.D. University of Kansas Medical Center	Progress in Development of a Vaccine Against HIV	Hiroaki Serizawa, Ph.D.
Friday, March 3, 2000	11:00 AM	Leonidas Tsiokas, Ph.D. University of Oklahoma Health Sciences Center	Molecular mechanisms in polysystic kidney disease	James Calvet, Ph.D.
Friday, March 10, 2000	11:00 AM	Sudhansu K. Dey, Ph.D. University of Kansas Medical Center	Molecular signaling in embryo implantation	Hiroaki Serizawa, Ph.D.
Friday, March 17, 2000	11:00 AM	Richard Silverstein, Ph.D. University of Kansas Medical Center	Beyond the Jarisch-Herxheimer reaction: involvement of TNF	Robin Maser, Ph.D.
Friday, March 24, 2000	11:00 AM	No Seminar-          SPRING BREAK	No Seminar	No Seminar
Friday, March 31, 2000	11:00 AM	Jing Zhou, M.D., Ph.D. Harvard Institutes of Medicine	How to identify functions of orphan genes, a lesson from polycystic kidney disease research	Billy G. Hudson, Ph.D.
Friday, April 7, 2000	11:00 AM	Stanely B. Prusiner, M.D. Nobel Prize Winner University of California, San Francisco	Prion Biology and Diseases-In Quest of Therapeutics	Graduate Students
Friday, April 14, 2000	11:00 AM	Harvey Fisher, Ph.D. VA Medical Center	Close-packed four-atom square motif serves as a variable-pathway mechanistic switching device in enzymatic catalysis	Hiroaki Serizawa, Ph.D.
Friday, April 21, 2000	11:00 AM	James Cowan, Ph.D.  Ohio State University of Columbus	Inorganic Nucleases.  New Chemistry for Antiviral Drug Design	R. Padmanabhan, Ph.D.
Friday, April 28, 2000	11:00 AM	No seminar scheduled	No seminar scheduled	No seminar scheduled
Friday, May 5, 2000	11:00 AM	Tom Roche, Ph.D.    Kansas State University	Regulation of Human Pyruvate Dehydrogenase Complex:  Predominant Impact of the Dihydrolipoyl Acetyltransferase on Kinase Isoform and Phosphatase Isoform 1 Activities	Mark Fisher, Ph.D.
Friday, May 12, 2000	11:00 AM	Thomas V. O'Halloran, Ph.D. Northwestern University	Intracellular Transition Metal Receptors in Trafficking and Gene Regulation	Glen Andrews, Ph.D.
Friday, May 19, 2000	11:00 AM	Thomas L. Poulos, Ph.D. University of California at Irvine	TBA	M. Sundarmoorthy, Ph.D.
Friday, May 26, 2000	11:00 AM	Jeff Minor, Ph.D.    Washington University	TBA	Dr. Mike Sarras-co-sponsored with Department of Anatomy

Fall 1999 Formal Seminars

Spring 1999 Biochemistry and Molecular Biology Seminars

• January 15, 1999, "Matrix Metalloproteinases and TIMPs: Structure and Function", Hideaki Nagase, Ph.D., Univesity of Kansas Medical Center, Department of Biochemistry & Molecular Biology, Kansas City, Kansas
• January 29, 1999, "MTF-1: A Zinc-Sensing Transcription Factor that Regulates Metallothionein Gene Expression", Glen Andrews, Ph.D., University of Kansas Medical Center, Department of Biochemistry & Molecular Biology, Kansas City, Kansas
• February 19, 1999, "Mammalian pyruvate dehydrogenase complex: structure and regulation", Kiril M. Popov, Ph.D., Univesity of Missouri - Kansas City, School of Biological Sciences, Kansas City, Missouri
• March 19, 1999, "Role of Proteolyzed Collagen in Angiogenesis and Tumor Growth", Peter Brooks, Ph.D., University of Southern California, Los Angeles, California
• March 26, 1999, "Galvanizing science:  the molecule biology of zinc homeostasis", David Eide, Ph.D., University of Missouri - Columbia, Columbia, Missouri
• April 2, 1999, "NAD(P)H:  Quinone Oxidoreductase expression in human neuroblastoma cells and Alzheimer's Disease", Jeffrey Johnson, Ph.D., University of Kansas Medical Center, Department of Pharmacology, Toxicology and Therapeutics
• April 9, 1999, "Evidence for vasculogenesis, not angiogenesis, in development of glomerular capillary wall", Dale Abrahamson, Ph.D., University of Kansas Medical Center, Department of Anatomy and Cell Biology
• April 16, 1999, "cAMP-GEFs - A Family of Guanine Nucleotide Exchange Factors that are Regulated by cAMP Binding", Stephen Parnell, Graduate Student, University of Kansas Medical Center, Department of Biochemistry and Molecular Biology
• April 23, 1999, "Structure and Interactions of TIMP, Angiogenesis Inhibitor, and a Metalloproteinase", Steve Van Doren, Ph.D., University of Missouri-Columbia, Department of Biochemistry
• April 30, 1999, "Naked mice:  Hair today, gone tomorrow", Alan Godwin, Ph.D., University of Kansas Medical Center, Department of Molecular and Integrative Physiology
• May 7, 1999, "Molecular mechanism of Tat transactivation in HIV-1 transcription:  Cyclin T1 is the TAR RNA binding cofactor for Tat", Shihyun You, Graduate Student, University of Kansas Medical Center, Department of Biochemistry and Molecular Biology
• May 14, 1999, "Cancer Gene Therapy using Adenovirus vector:   urokinase-type plasminogen activator-receptor (uPA-uPAR) - a potential target for controlling tumor invasion and metastasis", Pamarthi M. Mohan, Ph.D., Osmania University, Hyderabad, India, Department of Biochemistry
• May 21, 1999, "Identification of a novel nitrate reductase and its role in synapse formation", Michael Werle, Ph.D., University of Kansas Medical Center, Department of Anatomy and Cell Biology

Fall 1998 Biochemistry and Molecular Biology Seminars

• October 30, 1998, "A molecular approach of Alport syndrome and diffuse leiomyomatosis", Corrine Antignac, M.D., Ph.D., Director of Research, National Institute of Health and Medical Research, Necker Hospital, Rene Descartes University, Paris, France
  

Spring 1998 Biochemistry and Molecular Biology Seminars

• May 15, 1998, "The Role of Glycoproteins in Mediating Sperm-Egg Interactions", William J. Lennarz, Ph.D., Professor and Chairman, Department of Biochemistry and Cell Biology, SUNY at Stony Brook, Stony Brook, NY
  
• April 24, 1998, "Genetic dissection of the Src signaling pathway in Drosophila", Xiangyi Lu, Ph.D., Assistant Professor, Department of Biochemistry, Cell and Molecular Biology, University of Kansas, Lawrence, KS
  
• April 17, 1998, "Factors that control neuronal and pituitary development in the mouse", Heiner Westphal, M.D., Chief, LMGD/NICHD/NIH, Bethesda, MD
  
• March 20, 1998, "Are molecular chaperones as promiscuous as we thought ?", Ana J. Iriarte, Associate Professor, Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri-Kansas City, MO
  
• February 25, 1998, "The interaction of Rhino viruses with their cellular receptors", Michael Rossman, Ph.D., Hanley Professor, Department of Biological Sciences, Purdue University, West Lafayette, Indiana
  
• February 20, 1998, "Structure and Expression of the ypt1 gene of the Potato Late Blight Fungus, Phytophthora infestans", Robert Roxby, Ph.D., Research Director, Molecular Biology, Mid American Neurosciences Research Foundation, Kansas City, Missouri
  
• February 6, 1998, " The role of protein-protein interactions in receptor signaling", Benjamin L. Margolis, M.D., Assistant Investigator, Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan
  
• January 30, 1998, "Control of m-RNA stability by Herpes Simplex Virus", G. Sullivan Read, Ph.D., Division of Cellular Biology and Biophysics, School of Biological Sciences, University of Missouri-Kansas City, Kansas City, Missouri
  

• January 16, 1998, "Near-Field Scanning Optical Microscopy: A New Tool for High Resolution Studies", Robert C. Dunn, Ph.D., Department of Chemistry, University of Kansas, Lawrence, KS
  

• Fall 1997 Biochemistry and Molecular Biology Seminars

• December 5, 1997, "Collagen and CD-Rap in Early Chondrogenesis", Linda J. Sandell, Ph.D., Dept. of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, Missouri
  
• November 7, 1997, "Factors and Mechanisms Controlling Elongation by RNA Polymerase II", Joan Conaway, Ph.D., Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma
  
• October 31, 1997, "Role of Shc in the activation of the Ras/Erk signaling induced by tumor promoter phorbol esters and cytoskeletal reorganization", Yoshikuni Nagamine, Ph.D., Friedrich Miescher Institute, Switzerland
  
• Gene-Related Peptide (CGRP)," Douglas Burns, Ph.D., Research Associate Professor,
  Veteran's Administration Medical Center, Kansas City, Missouri
  
• October 10, 1997, "Regulatory Subunit Interactions within the Phosphorylase Kinase Hexadecamer," Gerald Carlson, Ph.D., Professor, University of Missouri-Kansas City
  
• September 24, 1997, "Light Transduction i