Department of Biochemistry and Molecular Biology Regulation of gene expression, polycystic kidney disease, kidney development, oxidative stress.
Research Papers
Maser, R. L., Vassmer, D., Magenheimer, B.S., and Calvet, J.P. Oxidant stress and reduced antioxidant enzyme protection in polycystic kidney disease . J. Am. Soc. Nephrology, in press.
Sutters*, M. Yamaguchi* T., Maser*, R.L., Magenheimer, B.S., St John, P.L., Abrahamson, D.L., Grantham, J.J., and Calvet, J.P. (2001) A stably transfected C-terminal polycystin-1 construct transforms the cAMP growth-responsive phenotype of M-1 cells. Kidney Int., 60:484-94.
Parnell, S. C., Magenheimer, B. S., Maser, R.L., and Calvet, J.P. (1999) Identification of the major site of in vitro PKA phosphorylation in the polycystin-1 C-terminal cytosolic domain. Biochem. Biophys. Res. Comm. 259: 539-43.
Gattone II, V. H., Maser, R. L., Tian, C., Rosenberg, J. M., and Branden, M. G. (1999) Developmental expression of urine concentration-associated genes and their altered expression in murine infantile-type polycystic kidney disease. Dev. Genet. 24: 309-18.
Parnell, S. C., Magenheimer, B. S., Maser, R.L., Rankin, C. A., Smine, A., Okamoto, T., and Calvet, J. P. (1998) The polycystic kidney disease-1 protein, polycystin-1, binds and activates heterotrimeric G-proteins. Biochem. Biophys. Res. Comm. 251: 625-31.
Davidow, C. J., Maser, R. L., Rome, L. A., Calvet, J. P., and Grantham, J.J. (1996) The cystic fibrosis transmembrane conductance regulator mediates transepithelial fluid secretion by human autosomal dominant polycystic kidney disease epithelium in vitro. Kidney Int. 50:208-218.
Hou, X., Maser, R. L., Magenheimer, B. S., and Calvet, J. P. (1996) A mouse kidney- and liver-expressed cDNA having homology with a prokaryotic parathion hydrolase (phosphotriester-ase) gene: abnormal expression in injured and polycystic kidneys. Gene 168:157-163.
Rankin, C.R., Ziemer, D. M., Maser, R. L., Foo, I., and Calvet, J. P. (1996) Growth characteristics of cells cultured from two murine models of polycystic kidney disease. In Vitro Cell. Dev. 32:100-106.
Maser, R. L., and Calvet, J. P. (1995) Analysis of differential gene expression in the kidney by differential cDNA screening, subtractive cloning, and mRNA differential display. Sem Nephrol. 15:29-42.
Maser, R. L., Magenheimer, B. S., and Calvet, J. P. (1994) Mouse plasma glutathione peroxidase: cDNA sequence analysis and renal proximal tubular expression and secretion. J. Biol. Chem. 269:27066-27073.
Maser, R. L., and Calvet, J. P. (1989) U3 small nuclear RNA can be psoralen cross-linked in vivo to the 5'-external transcribed spacer of pre-ribosomal RNA. Proc. Natl. Acad. Sci. U.S.A. 86:6523-6527.
Kunkel, G. R., Maser, R. L., Calvet, J. P., and Pederson, T. (1986) U6 small nuclear RNA is transcribed by RNA polymerase III. Proc. Natl. Acad. Sci. U.S.A. 83:8575-8579.
Quackenbush, R. L., Dilts, J. A., and Maser, R. L. (1982) Physical map of a plasmid from Caedibacter taeniospiralis 51. J. Bacteriology 152:939-942.
Abstracts
Davidow, C.J., Maser, R.L., Calvet, J.P. and Grantham, J.J. Cystic fibrosis transmembrane conductance regulator (CFTR) mediates transepithelial fluid secretion by human ADPKD cyst epithelium in vivo. J. Am. Soc. Nephrol., 6:693, 1995.
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