Gail and other Models
Mammographic Breast Density
Referral for tissue Assessment via random periareolar fine needle aspiration
BRCA1/2 testing (hereditary breast/ovarian cancer)
PTEN Testing (Cowden’s Syndrome)
HNPCC (hereditary non-polyposis colon cancer)
Oncovue (test for multiple genetic polymorphisms which may affect cancer risk)
Breast exam by Nurse Practitioner or Breast Medical Oncologist
Breast imaging (mammogram, sonography, breast MRI) with readings by dedicated breast radiologists William Smith, M.D., and Marc Inciardi, M.D.
Bioidentical hormones
Patches, oral troches, vaginal gel
Tamoxifen
Raloxifene
Referral for surgical consultation for prophylactic surgery
Excel (MAP.3) (NCI, Canada)
Brevail – Flaxseed derivative for pre-menopausal women not on oral contraceptives (NCI USA) (open)
Acolbifene for pre-menopausal high risk women on or off oral contraceptives (NCI USA) (starting Fall 2007)
Letrozole vs. placebo for postmenopausal women on HRT (U Kansas/Novartis) (open)
Diet & Exercise Trial for postmenopausal women not on HRT (NCI USA) (starting Fall 2007)
Stability of tumor suppression gene methylation and proliferation measured by Ki-67 (Avon) (closed to new accrual 11/06)
ROCA – blood monitoring test for ovarian cancer (accrual complete)
Multiple single nucleotide polymorphisms (SNP’s) for postmenopausal high risk women (open)
Oncovue testing – predicting risk through multiple SNP testing (open Fall 2007)
Oncimmune – early detection test for breast cancer for women undergoing yearly screening and RPFNA (open Fall 2007)
Incidence of Vitamin D deficiency in high risk women (opening Fall 2007)
Incidence of osteopenia (heel ultrasound) in high risk premenopausal women (opening Fall 2007)