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Reference #: KRI-1018-537579
Submit Date: 04/10/2002 10:07:59-0500
Presentation Type: platform
CONTACT: Margaret Kripke
M. D. Anderson Cancer Center (Box 113) 1515 Holcombe Boulevard Houston,
TX 77030
New measures of photoprotection
AUTHOR GROUP:
Margaret Kripke 1 Department of Immunology The University of Texas M. D. Anderson Cancer Center Houston, TX 77030 1
ABSTRACT: A decrease in the concentration of stratospheric ozone results in an increase in the amount of solar UVB (280-320nm) radiation that reaches the surface of the earth. Although UVB is involved in the formation of Vitamin D in skin and thus has beneficial effects on human health, excessive exposure to UVB contributes to skin cancer formation, skin aging, cataract formation, and potentially harmful effects on the immune system. Although, solar UV radiation is the major cause of human skin cancer, different types of skin cancer may be related to UV exposure in different ways. Of the three most common types of skin cancer, squamous cell carcinoma seems to have the most direct relationship to UVB radiation, in that the risk of developing this type of skin cancer is directly related to cumulative, lifetime exposure to solar UVB radiation. Basal cell carcinoma is also directly related to UVB exposure, but for melanoma, the skin cancer with the most lethal behavior, the picture is not so clear. Studies in a fish model indicated that UVA, as well as UVB, could lead to melanoma formation. Even though there is as yet no direct evidence that UVA exposure contributes to melanoma formation in humans, these findings have raised the possibility that ozone depletion, which affects only UVB radiation, might not affect the incidence of melanoma. Studies in other animal models and improved understanding of the molecular mechanisms of melanoma carcinogenesis are needed to resolve this important question. Exposing the skin to UVB can prevent certain immune responses and can even lead to a long-lasting state of specific immune suppression. These immunosuppressive effects of UVB radiation contribute to skin cancer formation. Moreover, in animal models, UVB irradiation has been shown to interfere with host resistance to infectious agents. These findings have raised the concern that increased UVB radiation could increase the prevalence and severity of infectious certain diseases in humans, as well as reduce the effectiveness of vaccinations. However, epidemiological or experimental evidence supporting this possibility is still lacking. Thus, increased UVB radiation is expected to increase the incidence of some skin cancers and cataract, but its impact on the incidence of and mortality from melanoma and infectious diseases remains to be determined.
Keywords: UVB
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